Pardis Sabeti
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Pardis Sabeti
Pardis Christine Sabeti ( fa, پردیس ثابتی; born December 25, 1975) is an Iranian-American computational biologist, medical geneticist and evolutionary geneticist. She developed a bioinformatic statistical method which identifies sections of the genome that have been subject to natural selection and an algorithm which explains the effects of genetics on the evolution of disease. In 2014, Sabeti was part of a team led by Christian Happi, a Cameroonian geneticist, which used advanced genomic sequencing technology to identify a single point of infection from an animal reservoir to a human in the Ebola outbreak in West Africa. RNA changes suggests that the first human infection was followed by exclusive human to human transmissions. The work led her to be named one of ''Time Magazine'''s Persons of the Year in 2014 (Ebola Fighters), and one of the ''Time'' 100 most influential people in 2015. Sabeti is a full professor in the Center for Systems Biology and Department of ...
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Tehran
Tehran (; fa, تهران ) is the largest city in Tehran Province and the capital of Iran. With a population of around 9 million in the city and around 16 million in the larger metropolitan area of Greater Tehran, Tehran is the most populous city in Iran and Western Asia, and has the second-largest metropolitan area in the Middle East, after Cairo. It is ranked 24th in the world by metropolitan area population. In the Classical era, part of the territory of present-day Tehran was occupied by Rhages, a prominent Median city destroyed in the medieval Arab, Turkic, and Mongol invasions. Modern Ray is an urban area absorbed into the metropolitan area of Greater Tehran. Tehran was first chosen as the capital of Iran by Agha Mohammad Khan of the Qajar dynasty in 1786, because of its proximity to Iran's territories in the Caucasus, then separated from Iran in the Russo-Iranian Wars, to avoid the vying factions of the previously ruling Iranian dynasties. The capital has been ...
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The Paul & Daisy Soros Fellowships For New Americans
The Paul & Daisy Soros Fellowships for New Americans, founded by Paul Soros and Daisy Soros in 1997, is a United States postgraduate fellowship for immigrants and children of immigrants. In 2021, the Fellowship received 2,445 applications and awarded 30 Fellowships for a selection rate of 1.2%. Each Fellow receives up to $90,000 in funding toward their graduate education, which can be in any field and at any university at the US. The Fellowship, which honors the contributions of immigrants to the US, was founded in 1997. In 2010, the couple had contributed a total of $75 million to the organization's charitable trust. Past fellows include United States Surgeon General, Vivek Murthy (1998 Fellow), the second-youngest Surgeon General to occupy the position, as well as the first of Indian descent. Other alumni include Iranian-American Ebola researcher Pardis Sabeti (2001 Fellow) and Fei-Fei Li (1999 Fellow), a Stanford professor and artificial intelligence expert. The Fellowship h ...
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Harvard T
Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher learning in the United States and one of the most prestigious and highly ranked universities in the world. The university is composed of ten academic faculties plus Harvard Radcliffe Institute. The Faculty of Arts and Sciences offers study in a wide range of undergraduate and graduate academic disciplines, and other faculties offer only graduate degrees, including professional degrees. Harvard has three main campuses: the Cambridge campus centered on Harvard Yard; an adjoining campus immediately across Charles River in the Allston neighborhood of Boston; and the medical campus in Boston's Longwood Medical Area. Harvard's endowment is valued at $50.9 billion, making it the wealthiest academic institution in the world. Endowment inc ...
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Time 100
''Time'' 100 (often stylized as ''TIME'' 100) is an annual listicle of the 100 most influential people in the world, assembled by the American news magazine ''Time''. First published in 1999 as the result of a debate among American academics, politicians, and journalists, the list is now a highly publicized annual event. Appearing on the list is often seen as an honor, and ''Time'' makes it clear that entrants are recognized for changing the world, regardless of the consequences of their actions. The final list of influential individuals is exclusively chosen by ''Time'' editors, with nominations coming from the ''Time'' 100 alumni and the magazine's international writing staff. Only the winner of the Reader's Poll, conducted days before the official list is revealed, is chosen by the general public. The corresponding commemorative gala is held annually in Manhattan. In 2019, Time began publishing the ''Time'' 100 Next list, which "spotlights 100 rising stars who are shaping the ...
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Time Person Of The Year
Person of the Year (called Man of the Year or Woman of the Year until 1999) is an annual issue of the United States news magazine and website ''Time'' featuring a person, a group, an idea, or an object that "for better or for worse ... has done the most to influence the events of the year". ''Time'' also runs an annual reader's poll that has no effect on the selection, which is made solely by the magazine's editors. Background The tradition of selecting a "Man of the Year" began in 1927, with ''Time'' editors contemplating the news makers of the year. The idea was also an attempt to remedy the editorial embarrassment earlier that year of not having aviator Charles Lindbergh on its cover following his historic transatlantic flight. By the end of the year, it was decided that a cover story featuring Lindbergh as the Man of the Year would serve both purposes. Selection U.S. presidents and national leaders Since the list began, every serving president of the United States has ...
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Time (magazine)
''Time'' (stylized in all caps) is an American news magazine based in New York City. For nearly a century, it was published Weekly newspaper, weekly, but starting in March 2020 it transitioned to every other week. It was first published in New York City on March 3, 1923, and for many years it was run by its influential co-founder, Henry Luce. A European edition (''Time Europe'', formerly known as ''Time Atlantic'') is published in London and also covers the Middle East, Africa, and, since 2003, Latin America. An Asian edition (''Time Asia'') is based in Hong Kong. The South Pacific edition, which covers Australia, New Zealand, and the Pacific Islands, is based in Sydney. Since 2018, ''Time'' has been published by Time USA, LLC, owned by Marc Benioff, who acquired it from Meredith Corporation. History ''Time'' has been based in New York City since its first issue published on March 3, 1923, by Briton Hadden and Henry Luce. It was the first weekly news magazine in the United St ...
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Ebola Outbreak In West Africa
The 2013–2016 epidemic of Ebola virus disease, centered in Western Africa, was the most widespread outbreak of the disease in history. It caused major loss of life and socioeconomic disruption in the region, mainly in Guinea, Liberia and Sierra Leone. The first cases were recorded in Guinea in December 2013; later, the disease spread to neighbouring Liberia and Sierra Leone, with minor outbreaks occurring in Ebola virus disease in Nigeria, Nigeria and Mali. Secondary infections of medical workers occurred in the United States and Spain. In addition, isolated cases were recorded in Senegal, the United Kingdom and Italy. The number of cases peaked in October 2014 and then began to decline gradually, following the commitment of substantial international resources. It caused significant mortality, with a considerable case fatality rate. By the end of the epidemic, 28,616 people had been infected; of these, 11,310 had died, for a case-fatality rate of 40%. , the World Heal ...
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Genomic Sequencing
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery. Knowledge of DNA sequences has become indispensable for basic biological research, DNA Genographic Projects and in numerous applied fields such as medical diagnosis, biotechnology, forensic biology, virology and biological systematics. Comparing healthy and mutated DNA sequences can diagnose different diseases including various cancers, characterize antibody repertoire, and can be used to guide patient treatment. Having a quick way to sequence DNA allows for faster and more individualized medical care to be administered, and for more organisms to be identified and cataloged. The rapid speed of sequencing attained with modern DNA ...
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Christian Happi
Christian Happi is a Professor of Molecular Biology and Genomics in the Department of Biological Sciences and the Director of the African Centre of Excellence for Genomics of Infectious Diseases, both at Redeemer’s University. He is known for leading the team of scientists that used genomic sequencing to identify a single point of infection from an animal reservoir to a human in the Ebola outbreak in West Africa. His research focus is on infectious diseases, including malaria, Lassa fever, Ebola virus disease, HIV, and SARS-CoV-2. Early life and education Professor Happi was born in Sangmélima, Cameroon, fourth of seven children. He graduated from the University of Yaounde, Cameroon, in 1993 with a Bachelor of Science in Biochemistry with honors. He obtained his PhD from the University of Ibadan, Nigeria, in 2000 and went on to Harvard University as a Postdoctoral Fellow from 2000 to 2003. He subsequently worked at Harvard University as a Research Scientist from 2004 to 2007 ...
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Natural Selection
Natural selection is the differential survival and reproduction of individuals due to differences in phenotype. It is a key mechanism of evolution, the change in the heritable traits characteristic of a population over generations. Charles Darwin popularised the term "natural selection", contrasting it with selective breeding, artificial selection, which in his view is intentional, whereas natural selection is not. Genetic diversity, Variation exists within all populations of organisms. This occurs partly because random mutations arise in the genome of an individual organism, and their offspring can inherit such mutations. Throughout the lives of the individuals, their genomes interact with their environments to cause variations in traits. The environment of a genome includes the molecular biology in the Cell (biology), cell, other cells, other individuals, populations, species, as well as the abiotic environment. Because individuals with certain variants of the trait tend ...
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Genome
In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of 'junk' DNA with no evident function. Almost all eukaryotes have mitochondria and a small mitochondrial genome. Algae and plants also contain chloroplasts with a chloroplast genome. The study of the genome is called genomics. The genomes of many organisms have been sequenced and various regions have been annotated. The International Human Genome Project reported the sequence of the genome for ''Homo sapiens'' in 200The Human Genome Project although the initial "finished" sequence was missing 8% of the genome consisting mostly of repetitive sequences. With advancements in technology that could handle sequenci ...
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Bioinformatic
Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combines biology, chemistry, physics, computer science, information engineering, mathematics and statistics to analyze and interpret the biological data. Bioinformatics has been used for ''in silico'' analyses of biological queries using computational and statistical techniques. Bioinformatics includes biological studies that use computer programming as part of their methodology, as well as specific analysis "pipelines" that are repeatedly used, particularly in the field of genomics. Common uses of bioinformatics include the identification of candidates genes and single nucleotide polymorphisms (SNPs). Often, such identification is made with the aim to better understand the genetic basis of disease, unique adaptations, desirable properties (esp. ...
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