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Photon Factory
The Photon Factory (PF) is a synchrotron located at KEK, in Tsukuba, Japan, about fifty kilometres from Tokyo. There are two major facilities, the Photon Factory itself which is a 2.5GeV synchrotron with a beam current of around 450mA, and the PF-AR 'Advanced Ring for Pulsed X-Rays', which is a 6.5GeV machine running in a single-bunch mode with a beam current of around 60mA. Its macromolecular crystallography beamline is used substantially for Japan's structural genomics Structural genomics seeks to describe the 3-dimensional structure of every protein encoded by a given genome. This genome-based approach allows for a high-throughput method of structure determination by a combination of experimental and modeling ... project. External linksPhoton Factory - KEK IMSS website Synchrotron radiation facilities {{particle-stub ...
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Synchrotron
A synchrotron is a particular type of cyclic particle accelerator, descended from the cyclotron, in which the accelerating particle beam travels around a fixed closed-loop path. The magnetic field which bends the particle beam into its closed path increases with time during the accelerating process, being ''synchronized'' to the increasing kinetic energy of the particles. The synchrotron is one of the first accelerator concepts to enable the construction of large-scale facilities, since bending, beam focusing and acceleration can be separated into different components. The most powerful modern particle accelerators use versions of the synchrotron design. The largest synchrotron-type accelerator, also the largest particle accelerator in the world, is the Large Hadron Collider (LHC) near Geneva, Switzerland, built in 2008 by the European Organization for Nuclear Research (CERN). It can accelerate beams of protons to an energy of 6.5 tera  electronvolts (TeV or 1012 eV). ...
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Tsukuba
is a city located in Ibaraki Prefecture, Japan. , the city had an estimated population of 244,528 in 108,669 households and a population density of 862 persons per km². The percentage of the population aged over 65 was 20.3%. The total area of the city is . It is known as the location of the , a planned science park developed in the 1960s. Geography Tsukuba is located in southern Ibaraki Prefecture, approximately 50 kilometers from central Tokyo and about 40 kilometers from Narita International Airport. Mount Tsukuba, from which the city takes its name is located in the northern part of the city. Except for the area around Mount Tsukuba, the city is a part of the Kantō Plain with an altitude of 20 to 30 meters. Mountains: Mount Tsukuba, Mount Hokyo. Rivers: Kokai River, Sakura River, Higashiyata River, Nishiyata River, Ono River, Hanamuro River, Inari River. Parks: The city has more of 100 parks and green areas to relax. Different parks are connected by pedestrian w ...
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Japan
Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north toward the East China Sea, Philippine Sea, and Taiwan in the south. Japan is a part of the Ring of Fire, and spans an archipelago of 6852 islands covering ; the five main islands are Hokkaido, Honshu (the "mainland"), Shikoku, Kyushu, and Okinawa. Tokyo is the nation's capital and largest city, followed by Yokohama, Osaka, Nagoya, Sapporo, Fukuoka, Kobe, and Kyoto. Japan is the eleventh most populous country in the world, as well as one of the most densely populated and urbanized. About three-fourths of the country's terrain is mountainous, concentrating its population of 123.2 million on narrow coastal plains. Japan is divided into 47 administrative prefectures and eight traditional regions. The Greater Tokyo Ar ...
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Tokyo
Tokyo (; ja, 東京, , ), officially the Tokyo Metropolis ( ja, 東京都, label=none, ), is the capital and List of cities in Japan, largest city of Japan. Formerly known as Edo, its metropolitan area () is the most populous in the world, with an estimated 37.468 million residents ; the city proper has a population of 13.99 million people. Located at the head of Tokyo Bay, the prefecture forms part of the Kantō region on the central coast of Honshu, Japan's largest island. Tokyo serves as Economy of Japan, Japan's economic center and is the seat of both the Government of Japan, Japanese government and the Emperor of Japan. Originally a fishing village named Edo, the city became politically prominent in 1603, when it became the seat of the Tokugawa shogunate. By the mid-18th century, Edo was one of the most populous cities in the world with a population of over one million people. Following the Meiji Restoration of 1868, the imperial capital in Kyoto was mov ...
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Macromolecular Crystallography
A macromolecule is a very large molecule important to biophysical processes, such as a protein or nucleic acid. It is composed of thousands of covalently bonded atoms. Many macromolecules are polymers of smaller molecules called monomers. The most common macromolecules in biochemistry are biopolymers (nucleic acids, proteins, and carbohydrates) and large non-polymeric molecules such as lipids, nanogels and macrocycles. Synthetic fibers and experimental materials such as carbon nanotubes are also examples of macromolecules. Definition The term ''macromolecule'' (''macro-'' + ''molecule'') was coined by Nobel laureate Hermann Staudinger in the 1920s, although his first relevant publication on this field only mentions ''high molecular compounds'' (in excess of 1,000 atoms). At that time the term ''polymer'', as introduced by Berzelius in 1832, had a different meaning from that of today: it simply was another form of isomerism for example with benzene and acetylene and had little ...
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Beamline
In accelerator physics, a beamline refers to the trajectory of the beam of particles, including the overall construction of the path segment (guide tubes, diagnostic devices) along a specific path of an accelerator facility. This part is either * the line in a linear accelerator along which a beam of particles travels, or * the path leading from particle generator (e.g. a cyclic accelerator, synchrotron light sources, cyclotrons, or spallation sources) to the experimental end-station. Beamlines usually end in experimental stations that utilize particle beams or synchrotron light obtained from a synchrotron, or neutrons from a spallation source or research reactor. Beamlines are used in experiments in particle physics, materials science, life science, chemistry, and molecular biology, but can also be used for irradiation tests or to produce isotopes. Beamline in a particle accelerator In particle accelerators the beamline is usually housed in a tunnel and/or unde ...
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Structural Genomics
Structural genomics seeks to describe the 3-dimensional structure of every protein encoded by a given genome. This genome-based approach allows for a high-throughput method of structure determination by a combination of experimental and modeling approaches. The principal difference between structural genomics and traditional structural prediction is that structural genomics attempts to determine the structure of every protein encoded by the genome, rather than focusing on one particular protein. With full-genome sequences available, structure prediction can be done more quickly through a combination of experimental and modeling approaches, especially because the availability of large number of sequenced genomes and previously solved protein structures allows scientists to model protein structure on the structures of previously solved homologs. Because protein structure is closely linked with protein function, the structural genomics has the potential to inform knowledge of prote ...
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