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Parallel Study
A parallel study is a type of clinical study where two groups of treatments, A and B, are given so that one group receives only A while another group receives only B. Other names for this type of study include "between patient" and "non-crossover". This is unlike a crossover study where at first one group receives treatment A and later followed by treatment B while the other group receives treatment B followed by treatment A. There are, however, certain characteristics that allow for differentiation between these two types of trials. For example, a parallel study would be more appropriate if any concerns about carryover effects were present. This type of study might also be more beneficial if the disease or disorder being studied has a likely chance of progression during the time in which the study takes place. One significant issue with parallel studies, though, is the concept of intra subject variability, which is defined as variability in response occurring within the same pat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Study
Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, pharmaceutical drug, drugs, medical nutrition therapy, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received institutional review board, health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial—their approval does not mean the therapy is 'safe' or effective, only that the trial may be conducted. Depending on product type and development stage, investigators initially enroll volunteers or patients into small Pilot experiment, pi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Treatment
A therapy or medical treatment is the attempted remediation of a health problem, usually following a medical diagnosis. Both words, ''treatment'' and ''therapy'', are often abbreviated tx, Tx, or Tx. As a rule, each therapy has indications and contraindications. There are many different types of therapy. Not all therapies are effective. Many therapies can produce unwanted adverse effects. ''Treatment'' and ''therapy'' are often synonymous, especially in the usage of health professionals. However, in the context of mental health, the term ''therapy'' may refer specifically to psychotherapy. Semantic field The words ''care'', ''therapy'', ''treatment'', and ''intervention'' overlap in a semantic field, and thus they can be synonymous depending on context. Moving rightward through that order, the connotative level of holism decreases and the level of specificity (to concrete instances) increases. Thus, in health-care contexts (where its senses are always noncount), t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crossover Study
In medicine, a crossover study or crossover trial is a longitudinal study in which subjects receive a sequence of different treatments (or exposures). While crossover studies can be observational studies, many important crossover studies are controlled experiments, which are discussed in this article. Crossover designs are common for experiments in many scientific disciplines, for example psychology, pharmaceutical science, and medicine. Randomized, controlled crossover experiments are especially important in health care. In a randomized clinical trial, the subjects are randomly assigned to different arms of the study which receive different treatments. When the trial has a repeated measures design, the same measures are collected multiple times for each subject. A crossover trial has a repeated measures design in which each patient is assigned to a sequence of two or more treatments, of which one may be a standard treatment or a placebo. Nearly all crossover are designed to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carryover Effect
The carryover effect is a term used in clinical chemistry to describe the transfer of unwanted material from one container or mixture to another. It describes the influence of one sample upon the following one. It may be from a specimen, or a reagent, or even the washing medium. The significance of carry over is that even a small amount can lead to erroneous results. Carryover effect in clinical laboratory Carryover experiments are widely used for clinical chemistry and immunochemistry analyzers to evaluate and validate carryover effects. The pipetting and washing systems in an automated analyzer are designed to continuously cycle between the aspiration of patient specimens and cleaning. An obvious concern is a potential for carryover of analyte from one patient specimen into one or more following patient specimens, which can falsely increase or decrease the measured analyte concentration. Specimen carryover is typically addressed by judicious choice of probe material, probe d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intra Subject Variability
''Intra'' may refer to: * ''Intra'' (album), a 2005 album by metal band Ram-Zet * Intra, Italy, a former ''comune'' which is now a ''frazione'' of Verbania * Intra Airways, British airline * Intra (software), anti Internet censorship Android app by Google. * Intra-frame coding, a video compression technique that utilizes I-frames, a video compression picture type * Intra Bank, Lebanese bank * Intra (Teka), Norwegian company * Groupe INTRA, French emergency response organization * AVC-Intra AVC-Intra is a type of video coding developed by Panasonic, and then supported in products made by other companies. AVC-Intra is available in Panasonic's high definition broadcast products, such as, for example, their P2 card equipped broadcast c ..., a type of video coding People with the surname * Enrico Intra (born 1935), Italian pianist, composer, and conductor * Giovanni Intra (1968–2002), New Zealand artist, writer, and art dealer See also * {{disambiguation, surna ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Randomization
Randomization is a statistical process in which a random mechanism is employed to select a sample from a population or assign subjects to different groups.Oxford English Dictionary "randomization" The process is crucial in ensuring the random allocation of experimental units or treatment protocols, thereby minimizing selection bias and enhancing the Validity (statistics), statistical validity. It facilitates the objective comparison of treatment effects in Design of experiments, experimental design, as it equates groups statistically by balancing both known and unknown factors at the outset of the study. In statistical terms, it underpins the principle of probabilistic equivalence among groups, allowing for the unbiased estimation of treatment effects and the generalizability of conclusions drawn from sample data to the broader population. Randomization is not haphazard; instead, a stochastic process, random process is a sequence of random variables describing a process whose outcom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Placebo
A placebo ( ) can be roughly defined as a sham medical treatment. Common placebos include inert tablets (like sugar pills), inert injections (like saline), sham surgery, and other procedures. Placebos are used in randomized clinical trials to test the efficacy of medical treatments. In a placebo-controlled trial, any change in the control group is known as the ''placebo response'', and the difference between this and the result of no treatment is the ''placebo effect''. Placebos in clinical trials should ideally be indistinguishable from so-called verum treatments under investigation, except for the latter's particular hypothesized medicinal effect. This is to shield test participants (with their consent) from knowing who is getting the placebo and who is getting the treatment under test, as patients' and clinicians' expectations of efficacy can influence results. The idea of a placebo effect was discussed in 18th century psychology, but became more prominent in the 20th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Trials
Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, pharmaceutical drug, drugs, medical nutrition therapy, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received institutional review board, health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial—their approval does not mean the therapy is 'safe' or effective, only that the trial may be conducted. Depending on product type and development stage, investigators initially enroll volunteers or patients into small Pilot experiment, pi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
