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Old (film)
''Old'' is a 2021 American thriller film written, directed, and produced by M. Night Shyamalan. It is based on the French-language Swiss graphic novel ''Sandcastle'' by Pierre Oscar Levy and Frederik Peeters. The film features an ensemble cast consisting of Gael García Bernal, Vicky Krieps, Rufus Sewell, Alex Wolff, Thomasin McKenzie, Abbey Lee, Nikki Amuka-Bird, Ken Leung, Eliza Scanlen, Aaron Pierre, Embeth Davidtz, and Emun Elliott. The plot follows a group of people who find themselves aging rapidly on a secluded beach. Shyamalan decided to adapt ''Sandcastle'' into a film after receiving it as a Father's Day gift in 2017. The then-untitled project was announced in September 2019, with the filmmaker revealing a partnership with Universal Pictures. The following year, filming took place in the Dominican Republic for three months, during the COVID-19 pandemic, with cinematographer Michael Gioulakis. ''Old'' premiered at Jazz at Lincoln Center in New York City on July ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frederik Peeters
Frédérik Peeters (; born 14 August 1974 in Geneva) is a contemporary Swiss graphic novelist. Biography Peeters received his bachelor of arts degree in visual communication from the École Supérieure d’Arts Appliqués in Geneva in 1995. Peeters currently lives with his partner Cati, her son, and their daughter in Geneva. His autobiographical graphic novel ''Blue Pills'' received the Polish Jury Prize at the Angoulême International Comics Festival, where it was also nominated for Best Book. ''Blue Pills'' also won the Premios La Cárcel de Papel in Spain for Best Foreign Comic. This is his first work to be translated into English. Other graphic novels include ''Pachyderme'' (nominated for the Grand Prix at the Angoulême International Comics Festival 2010), ''Lupus'', ''RG'', and ''Koma''. He has worked with documentary film-maker Pierre Oscar Lévy on an adaptation of Blue Pills for that medium. Subsequently, in 2010 the two collaborated on a science fiction graphic novel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jazz At Lincoln Center
Jazz at Lincoln Center is part of Lincoln Center in New York City. The organization was founded in 1987 and opened at Time Warner Center in October 2004. Wynton Marsalis is the artistic director and the leader of the Jazz at Lincoln Center Orchestra. The center hosts performances by the orchestra and by visiting musicians. Many concerts are streamed live on the center's YouTube channel. The center also presents educational programs in its home buildings, online, and in schools throughout the country. History In 1987, trumpeter Wynton Marsalis was involved in starting the Classical Jazz concert series, the first series of jazz concerts at Lincoln Center. In 1996, the Jazz at Lincoln Center organization became a constituent of Lincoln Center next to organizations such as the New York Philharmonic and the Metropolitan Opera. The budget for Jazz at Lincoln Center was $4 million in 1996, compared to $150 million for the Metropolitan Opera. In 2016, its budget was over $50 million. W ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexa Swinton
Alexa Skye Swinton is an American actress, singer and songwriter. She appeared in a lead role as Piper in the 13-episode ABC prime time series called ''Emergence'', has a recurring role as Eva Rhoades in '' Billions'', and the HBO series '' And Just Like That...'', where she plays the character of Rose Goldenblatt. She appeared in M. Night Shyamalan's ''Old'', playing the role of Young Maddox. Career Swinton originated the role of Addie in ''Make Believe'', written by Bess Wohl, and directed by Jackson Gay at the Hartford Stage. Swinton's first leading role in television was as Piper in ''Emergence.'' The show ran for 13 episodes from 2019 to 2020. She first performed her original song "You, Me and My Purple Docs" publicly on Canadian TV station CHCH-DT in Hamilton, Ontario. Swinton has a recurring role as Eva Rhoades, the daughter of main characters Chuck and Wendy Rhoades in Showtime’s television drama '' Billions''. She acted in M. Night Shyamalan's feature film ''Old'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Trial
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial—their approval does not mean the therapy is 'safe' or effective, only that the trial may be conducted. Depending on product type and development stage, investigators initially enroll volunteers or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypocalcemia
Hypocalcemia is a medical condition characterized by low calcium levels in the blood serum. The normal range of blood calcium is typically between 2.1–2.6 mmol/L (8.8–10.7 mg/dL, 4.3–5.2 mEq/L) while levels less than 2.1 mmol/L are defined as hypocalcemic. Mildly low levels that develop slowly often have no symptoms. Otherwise symptoms may include numbness, muscle spasms, seizures, confusion, or cardiac arrest. The most common cause for hypocalcemia is iatrogenic hypoparathyroidism. Other causes include other forms of hypoparathyroidism, vitamin D deficiency, kidney failure, pancreatitis, calcium channel blocker overdose, rhabdomyolysis, tumor lysis syndrome, and medications such as bisphosphonates or denosumab. Diagnosis should generally be confirmed with a corrected calcium or ionized calcium level. Specific changes may be seen on an electrocardiogram (ECG). Initial treatment for severe disease is with intravenous calcium chloride and possibly magnesium ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epileptic Seizure
An epileptic seizure, informally known as a seizure, is a period of symptoms due to abnormally excessive or synchronous neuronal activity in the brain. Outward effects vary from uncontrolled shaking movements involving much of the body with loss of consciousness ( tonic-clonic seizure), to shaking movements involving only part of the body with variable levels of consciousness ( focal seizure), to a subtle momentary loss of awareness (absence seizure). Most of the time these episodes last less than two minutes and it takes some time to return to normal. Loss of bladder control may occur. Seizures may be provoked and unprovoked. Provoked seizures are due to a temporary event such as low blood sugar, alcohol withdrawal, abusing alcohol together with prescription medication, low blood sodium, fever, brain infection, or concussion. Unprovoked seizures occur without a known or fixable cause such that ongoing seizures are likely. Unprovoked seizures may be exacerbated by stress or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schizophrenia
Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdrawal, decreased emotional expression, and apathy. Symptoms typically develop gradually, begin during young adulthood, and in many cases never become resolved. There is no objective diagnostic test; diagnosis is based on observed behavior, a history that includes the person's reported experiences, and reports of others familiar with the person. To be diagnosed with schizophrenia, symptoms and functional impairment need to be present for six months (DSM-5) or one month (ICD-11). Many people with schizophrenia have other mental disorders, especially substance use disorders, depressive disorders, anxiety disorders, and obsessive–compulsive disorder. About 0.3% to 0.7% of people are diagnosed with schizophrenia during their lifetime. In 2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neoplasm
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass, when it may be called a tumor. ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. Malignant neoplasms are also simply known as cancers and are the focus of oncology. Prior to the abnormal growth of tissue, as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or dysplasia. However, metaplasia or dysplasia does not always progress to neoplasia and can occur in other conditions as well. The word is from Ancient Greek 'new' and 'formation, creation'. Types A neoplasm can be benign, potentially ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aging
Ageing ( BE) or aging ( AE) is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. In a broader sense, ageing can refer to single cells within an organism which have ceased dividing, or to the population of a species. In humans, ageing represents the accumulation of changes in a human being over time and can encompass physical, psychological, and social changes. Reaction time, for example, may slow with age, while memories and general knowledge typically increase. Ageing increases the risk of human diseases such as cancer, Alzheimer's disease, diabetes, cardiovascular disease, stroke and many more. Of the roughly 150,000 people who die each day across the globe, about two-thirds die from age-related causes. Current ageing theories are assigned to the damage concept, whereby the accumulation of damage (such as DNA ox ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemophilia
Haemophilia, or hemophilia (), is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. This results in people bleeding for a longer time after an injury, easy bruising, and an increased risk of bleeding inside joints or the brain. Those with a mild case of the disease may have symptoms only after an accident or during surgery. Bleeding into a joint can result in permanent damage while bleeding in the brain can result in long term headaches, seizures, or a decreased level of consciousness. There are two main types of haemophilia: haemophilia A, which occurs due to low amounts of clotting factor VIII, and haemophilia B, which occurs due to low levels of clotting factor IX. They are typically inherited from one's parents through an X chromosome carrying a nonfunctional gene. Rarely a new mutation may occur during early development or haemophilia may develop later in life due to antibodies forming against ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COVID-19 Pandemic
The COVID-19 pandemic, also known as the coronavirus pandemic, is an ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The novel virus was first identified in an outbreak in the Chinese city of Wuhan in December 2019. Attempts to contain it there failed, allowing the virus to spread to other areas of Asia and later worldwide. The World Health Organization (WHO) declared the outbreak a public health emergency of international concern on 30 January 2020, and a pandemic on 11 March 2020. As of , the pandemic had caused more than cases and confirmed deaths, making it one of the deadliest in history. COVID-19 symptoms range from undetectable to deadly, but most commonly include fever, dry cough, and fatigue. Severe illness is more likely in elderly patients and those with certain underlying medical conditions. COVID-19 transmits when people breathe in air contaminated by droplets and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Father's Day
Father's Day is a holiday of honoring fatherhood and paternal bonds, as well as the influence of fathers in society. In Catholic countries of Europe, it has been celebrated on 19 March as Saint Joseph's Day since the Middle Ages. In the United States, Father's Day was founded by Sonora Smart Dodd, and celebrated on the third Sunday of June for the first time in 1910. The day is held on various dates across the world, and different regions maintain their own traditions of honoring fatherhood. Father's Day is a recognized public holiday in Lithuania and some parts of Spain and was regarded as such in Italy until 1977. It is a national holiday in Estonia, Samoa, and equivalently in South Korea, where it is celebrated as Parents' Day. The holiday complements similar celebrations honoring family members, such as Mother's Day, Siblings Day, and Grandparents' Day. History Early history For centuries, the Eastern Orthodox Church has appointed the second Sunday before Nativity as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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