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Mylan
Mylan N.V. was a global generic and specialty pharmaceuticals company. In November 2020, Mylan merged with Upjohn, Pfizer's off-patent medicine division, to form Viatris. Previously, the company was domiciled in the Netherlands, with principal executive offices in Hatfield, Hertfordshire, UKMylan N10-K for the Fiscal Year Ended December 31, 2015/ref> and a "Global Center" in Canonsburg, Pennsylvania, US. In 2007, the company acquired a controlling interest in India-based Matrix Laboratories Limited, a top producer of active pharmaceutical ingredients (APIs) for generic drugs, and the generics business of Germany-based Merck KGaA. Through these acquisitions, the company grew from the third-largest generic and pharmaceuticals company in the United States to the second-largest generic and specialty pharmaceuticals company in the world. Mylan went public on the OTC market in February 1973. It was listed on the NASDAQ, and its shares were a component of the NASDAQ Biotechnology an ...
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Viatris
Viatris Inc. is an American global pharmaceutical and healthcare corporation headquartered in Canonsburg, Pennsylvania. The corporation was formed through the merger of Mylan and Upjohn, a legacy division of Pfizer, on November 16, 2020. The name of the corporation comes from the Latin words ''via'', meaning path, and ''tris'', which means three, referring to the path to three main objectives the corporation set. Viatris ranked 254th on the 2021 ''Fortune'' 500 rankings of the largest United States corporations based on its 2020 total revenue. History On November 16, 2020, Upjohn merged with Mylan in a Reverse Morris Trust transaction and changed its name to Viatris. At that time, Michael Goettler became chief executive officer. Following the combination, the company began trading on the NASDAQ using the ticker symbol VTRS. In December 2020, the company announced a cost-reducing restructuring plan which would impact up to 20% of its global workforce, or 9,000 jobs at its f ...
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Milan Puskar
Milan "Mike" Puškar (September 8, 1934 – October 7, 2011) was an American entrepreneur and philanthropist from Morgantown, West Virginia. Biography Puskar was born in Vintondale, Pennsylvania, to ethnic Serbian parents from Kordun. He graduated from Youngstown State University in 1960. In 1961, he and Don Panoz co-founded a pharmaceutical company which became Mylan Inc. Puskar was Mylan's president from 1976 through 2000. In November 1993, aged 58, he became the company's chairman and chief executive officer. He served as CEO until 2002 and as chairman until 2009. Following his retirement as CEO, his successor Robert J. Coury drastically cut employee benefits and blocked Puskar from entering Mylan’s Morgantown facility, and Puskar came to regret putting him in charge of the company. West Virginia University's Milan Puskar Stadium was named for him after he made a US$20 million donation. Morgantown Health Right a free clinic was renamed Milan Puskar Health Right ...
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Don Panoz
Donald Panoz ( or ; February 13, 1935 – September 11, 2018) was an American entrepreneur who founded various pharmaceutical companies. Early life Panoz was an Italian-American. His father, Eugene Panunzio, immigrated to the United States from Avezzano, Italy in the 1900s. Eugene, who shortened his surname from the original ''Panunzio'' to ''Panoz'', was a champion featherweight boxer. Panoz attended Greenbrier Military School in Lewisburg, West Virginia, where he met Nancy, whom he would later marry. The two both served in Japan with the United States Army, then moved to Pittsburgh upon their return to the United States. Business career Panoz operated two drug stores in Pittsburgh while studying business at Duquesne University. In 1961, Panoz and Milan Puskar formed Milan Pharmaceuticals (which would later be renamed ''Mylan'') in White Sulphur Springs, West Virginia. While head of this company, Panoz headed a research group that invented time-release medication throug ...
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Upjohn
The Upjohn Company was a pharmaceutical manufacturing firm founded in 1886 in Hastings, Michigan, by Dr. William E. Upjohn who was an 1875 graduate of the University of Michigan medical school. The company was originally formed to make ''friable pills'', which were specifically designed to be easily digested. These could be "reduced to a powder under the thumb", a strong marketing argument at the time. History Upjohn developed a process for the large scale production of cortisone. The oxygen atom at the 11 position in this steroid is an absolute requirement for biological activity. There are however no known natural sources for starting materials that contain that feature. The only method for preparing this drug prior to 1952 was a lengthy synthesis starting from cholic acid isolated from bile. In 1952, two Upjohn biochemists, Dury Peterson and Herb Murray announced that they were able to introduce this crucial oxygen atom by fermentation of the steroid progesterone with a c ...
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Pfizer
Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer (1824–1906) and his cousin Charles F. Erhart (1821–1891). Pfizer develops and produces medicines and vaccines for immunology, oncology, cardiology, endocrinology, and neurology. The company has several blockbuster drugs or products that each generate more than billion in annual revenues. In 2020, 52% of the company's revenues came from the United States, 6% came from each of China and Japan, and 36% came from other countries. Pfizer was a component of the Dow Jones Industrial Average stock market index from 2004 to August 2020. The company ranks 64th on the Fortune 500 and 49th on the Forbes Global 2000. History 1849–1950: Early history Pfizer was founded in 1849 by Charles Pfizer and Charles F. Erhart, two cousins ...
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Merck KGaA
The Merck Group, branded and commonly known as Merck, is a German multinational science and technology company headquartered in Darmstadt, with about 60,000 employees and present in 66 countries. The group includes around 250 companies; the main company is Merck KGaA in Germany. The company is divided into three business lines: Healthcare, Life Sciences and Electronics. Merck was founded in 1668 and is the world's oldest operating chemical and pharmaceutical company, as well as one of the largest pharmaceutical companies in the world. Merck operates in Europe, Africa, Asia, Oceania and the Americas. It has major research and development centres in Darmstadt, Boston, Tokyo and Beijing, as well as other Research and Development units in Taiwan, France, Israel, South Korea, India and in the UK. Merck pioneered the commercial manufacture of morphine in the 19th century and for a time held a virtual monopoly on cocaine. Merck was privately owned until going public on the Frankfurt ...
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Generic Drug
A generic drug is a pharmaceutical drug that contains the same chemical substance as a drug that was originally protected by chemical patents. Generic drugs are allowed for sale after the patents on the original drugs expire. Because the active chemical substance is the same, the medical profile of generics is equivalent in performance. A generic drug has the same active pharmaceutical ingredient (API) as the original, but it may differ in some characteristics such as the manufacturing process, formulation, excipients, color, taste, and packaging. Although they may not be associated with a particular company, generic drugs are usually subject to government regulations in the countries in which they are dispensed. They are labeled with the name of the manufacturer and a generic non-proprietary name such as the United States Adopted Name (USAN) or International Nonproprietary Name (INN) of the drug. A generic drug must contain the same active ingredients as the original brand- ...
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The Pittsburgh Tribune-Review
The ''Pittsburgh Tribune-Review'', also known as "the Trib," is the second largest daily newspaper serving metropolitan Pittsburgh, Pennsylvania, in the United States. Although it transitioned to an all-digital format on December 1, 2016, it remains the second largest daily in the state, with nearly one million unique page views a month. Founded on August 22, 1811, as the ''Greensburg Gazette'' and in 1889 consolidated with several papers into the ''Greensburg Tribune-Review'', the paper circulated only in the eastern suburban counties of Westmoreland and parts of Indiana and Fayette until May 1992, when it began serving all of the Pittsburgh metropolitan area after a strike at the two Pittsburgh dailies, the ''Pittsburgh Post-Gazette'' and '' Pittsburgh Press'', deprived the city of a newspaper for several months. The Tribune-Review Publishing Company was owned by Richard Mellon Scaife, an heir to the Mellon banking, oil, and aluminum fortune, until his death in July 2014. Sc ...
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NASDAQ Biotechnology
The NASDAQ Biotechnology Index is a stock market index made up of securities of NASDAQ-listed companies classified according to the Industry Classification Benchmark as either the Biotechnology or the Pharmaceutical industry The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered to patients (or self-administered), with the aim to cure them, vaccinate them, or alleviate symptoms. .... A list of the 213 components of the index is publisheonline Criteria In order to remain included within the index, the components must meet the following criteria: * The security U.S. listing must be exclusively on the NASDAQ National Market (unless the security was dually listed on another U.S. market prior to January 1, 2004 and has continuously maintained such listing). * The issuer of the security must be classified according to the Industry Classification Benchmark as either Biotechnology or Pharmaceutical ...
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S&P 500
The Standard and Poor's 500, or simply the S&P 500, is a stock market index tracking the stock performance of 500 large companies listed on stock exchanges in the United States. It is one of the most commonly followed equity indices. As of December 31, 2020, more than $5.4 trillion was invested in assets tied to the performance of the index. The S&P 500 index is a free-float weighted/capitalization-weighted index. As of August 31, 2022, the nine largest companies on the list of S&P 500 companies accounted for 27.8% of the market capitalization of the index and were, in order of highest to lowest weighting: Apple, Microsoft, Alphabet (including both class A & C shares), Amazon.com, Tesla, Berkshire Hathaway, UnitedHealth Group, Johnson & Johnson and ExxonMobil. The components that have increased their dividends in 25 consecutive years are known as the S&P 500 Dividend Aristocrats. The index is one of the factors in computation of the Conference Board Leading Economic ...
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Management Of HIV/AIDS
The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs as a strategy to control HIV infection. There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle. The use of multiple drugs that act on different viral targets is known as highly active antiretroviral therapy (HAART). HAART decreases the patient's total burden of HIV, maintains function of the immune system, and prevents opportunistic infections that often lead to death. HAART also prevents the transmission of HIV between serodiscordant same sex and opposite sex partners so long as the HIV-positive partner maintains an undetectable viral load. Treatment has been so successful that in many parts of the world, HIV has become a chronic condition in which progression to AIDS is increasingly rare. Anthony Fauci, head of the United States National Institute of Allergy and Infectious Diseases, has written, "With collective and resolute action now and a ste ...
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