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Müllerian System
The paramesonephric ducts (or Müllerian ducts) are paired ducts of the embryo in the reproductive system of humans and other mammals that run down the lateral sides of the genital ridge and terminate at the sinus tubercle in the primitive urogenital sinus. They form in both sexes during 6th week of fetal development. In the female, go on to form the fallopian tubes/oviducts, uterus, cervix, and the upper one-third of the vagina. In males fetuses, they are normally made to regress by anti-Müllerian hormone which begins to be secreted by the testes during 8th week of fetal development. Each maramesonephric duct is situated just lateral to the mesonephric ducts, mesonephric ducts (Wolffian duct) of the same side. Development The female reproductive system is composed of two embryological segments: the urogenital sinus and the paramesonephric ducts. The two are conjoined at the sinus tubercle. Paramesonephric ducts are present on the embryo of both sexes. Only in females do they d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Urogenital Sinus
The urogenital sinus is a body part of a human or other Placentalia, placental only present in the development of the urinary system, development of the urinary and development of the reproductive organs, reproductive organs. It is the ventral part of the cloaca, formed after the cloaca (embryology), cloaca separates from the anal canal during the fourth to seventh weeks of development. In males, the UG sinus is divided into three regions: upper, pelvic, and phallic. The upper part gives rise to the urinary bladder and the pelvic part gives rise to the prostatic and membranous parts of the urethra, the prostate and the bulbourethral glands (Cowper's). The phallic portion gives rise to the spongy (bulbar) part of the urethra and the urethral glands (Littré's). In females, the pelvic part of the UG sinus gives rise to the sinovaginal bulbs, structures that will eventually form the inferior two thirds of the vagina. This process begins when the lower tip of the paramesonephric ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uterine Tubes
The fallopian tubes, also known as uterine tubes, oviducts or salpinges (: salpinx), are paired tubular sex organs in the human female body that stretch from the ovaries to the uterus. The fallopian tubes are part of the female reproductive system. In other vertebrates, they are only called oviducts. Each tube is a muscular hollow organ that is on average between in length, with an external diameter of . It has four described parts: the intramural part, isthmus, ampulla, and infundibulum with associated fimbriae. Each tube has two openings: a proximal opening nearest to the uterus, and a distal opening nearest to the ovary. The fallopian tubes are held in place by the mesosalpinx, a part of the broad ligament mesentery that wraps around the tubes. Another part of the broad ligament, the mesovarium suspends the ovaries in place. An egg cell is transported from an ovary to a fallopian tube where it may be fertilized in the ampulla of the tube. The fallopian tubes are line ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Appendix Testis
The appendix testis (or hydatid of Morgagni) is a vestigial remnant of the Müllerian duct, present on the upper pole of the testis and attached to the tunica vaginalis. It is present about 90% of the time. Clinical significance Torsion The appendix of testis can occasionally become twisted, causing acute one-sided testicular pain and may require surgical excision to achieve relief. One third of patients present with a palpable "blue dot" discoloration on the scrotum. This is nearly diagnostic of this condition. If clinical suspicion is high for the serious differential diagnosis In healthcare, a differential diagnosis (DDx) is a method of analysis that distinguishes a particular disease or condition from others that present with similar clinical features. Differential diagnostic procedures are used by clinicians to di ... of testicular torsion, a surgical exploration of the scrotum is warranted. Torsion of the appendix of testis occurs at ages 0–15 years, with a mean ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vagina Masculina
The prostatic utricle (Latin for "small pouch of the prostate") is a small indentation in the prostatic urethra, at the apex of the urethral crest, on the seminal colliculus (''verumontanum''), laterally flanked by openings of the ejaculatory ducts. It is also known as the ''vagina masculina'', ''uterus masculinus'' or (in older literature) ''vesicula prostatica''. Structure It is often described as "blind", meaning that it is a duct that does not lead to any other structures. It tends to be about one cm in length. It can sometimes be enlarged. The utricle is deemed enlarged if it allows insertion of a cystoscope at least 2 cm deep. This is often associated with hypospadias. Function The prostatic utricle is a remnant that is homologous to the female uterus (including the cervix) and vagina, usually described as derived from the paramesonephric ducts, although this is occasionally disputed. In 1905, Robert William Taylor described the function of the utricle: "In coitus i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Persistent Müllerian Duct Syndrome
Persistent Müllerian duct syndrome (PMDS) is the presence of Müllerian duct derivatives (fallopian tubes, uterus, and/or the upper part of the vagina) in what would be considered a genetically and otherwise physically normal male. In humans, PMDS typically is due to an autosomal recessive congenital disorder and is considered by some to be a form of pseudohermaphroditism due to the presence of Müllerian derivatives. PMDS can also present in non-human animals. Typical features include undescended testes ( cryptorchidism) and the presence of a small, underdeveloped uterus in an XY infant or adult. This condition is usually caused by deficiency of fetal anti-Müllerian hormone (AMH) effect due to mutations of the gene for AMH or the anti-Müllerian hormone receptor, but may also be as a result of insensitivity to AMH of the target organ. Presentation The first visible signs of PMDS after birth is cryptorchidism (undescended testes) either unilaterally or bilaterally, as well ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Testes
A testicle or testis ( testes) is the gonad in all male bilaterians, including humans, and is homologous to the ovary in females. Its primary functions are the production of sperm and the secretion of androgens, primarily testosterone. The release of testosterone is regulated by luteinizing hormone (LH) from the anterior pituitary gland. Sperm production is controlled by follicle-stimulating hormone (FSH) from the anterior pituitary gland and by testosterone produced within the gonads. Structure Appearance Males have two testicles of similar size contained within the scrotum, which is an extension of the abdominal wall. Scrotal asymmetry, in which one testicle extends farther down into the scrotum than the other, is common. This is because of the differences in the vasculature's anatomy. For 85% of men, the right testis hangs lower than the left one. Measurement and volume The volume of the testicle can be estimated by palpating it and comparing it to ellipsoids (an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
WNT7A
Protein Wnt-7a is a protein that in humans is encoded by the ''WNT7A'' gene. Function The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% amino acid identity to the mouse Wnt7A protein. This gene not only guides the development of the anterior-posterior axis in the female reproductive tract but also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. It is also responsive to changes in the levels of sex steroid hormone in the female reproductive tract. Decreased expression of this gene in human uterine leiomyoma is found to be inversely associated with the expression of estrogen receptor alpha. Santos syndrome Santos syndrome is characterized ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
WNT9B
Protein WNT9B (formerly WNT15) is a protein that in humans is encoded by the ''WNT9B'' gene. The WNT family of genes produce glycolipoproteins that are involved with signaling and developmental processes. Like other Wnt genes, WNT9B codes for the WNT9B protein which participates in the canonical Wnt/β-catenin signaling pathway. WNT9B is a gene found on chromosome 17 in region 17q21. It can be traced to function in the establishment of the kidneys, because WNT9 is critical for morphogenesis of the nephron. This gene can impact kidney function in more than one way. Improper expression of the gene can cause cyst development on the kidney tubules, and in mice, mutant WNT9 genes that cause lower protein concentrations resulted in failure of the kidneys to thrive shortly after birth. WNT9B is a gene that often expressed in the epithelial cells of the Wolffian duct in early male and female embryos. In the embryos, Wnt11 is expressed at the branching points of the kidney tubules wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Urogenital Sinus
The urogenital sinus is a body part of a human or other Placentalia, placental only present in the development of the urinary system, development of the urinary and development of the reproductive organs, reproductive organs. It is the ventral part of the cloaca, formed after the cloaca (embryology), cloaca separates from the anal canal during the fourth to seventh weeks of development. In males, the UG sinus is divided into three regions: upper, pelvic, and phallic. The upper part gives rise to the urinary bladder and the pelvic part gives rise to the prostatic and membranous parts of the urethra, the prostate and the bulbourethral glands (Cowper's). The phallic portion gives rise to the spongy (bulbar) part of the urethra and the urethral glands (Littré's). In females, the pelvic part of the UG sinus gives rise to the sinovaginal bulbs, structures that will eventually form the inferior two thirds of the vagina. This process begins when the lower tip of the paramesonephric ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
WNT4
WNT4 is a secreted protein that, in humans, is encoded by the ''WNT4'' gene, found on chromosome 1. It promotes female sex development and represses male sex development. Loss of function may have consequences, such as female to male sex reversal. Function The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and embryogenesis. Pregnancy WNT4 is involved in many features of pregnancy as a downstream target of BMP2. For example, it regulates endometrial stromal cell proliferation, survival, and differentiation. These processes are all necessary for the development of an embryo. Ablation in female mice results in subfertility, with defects in implantation and decidualization. For instance, there is a decrease in responsiveness to progesterone signaling. Furthermore, postnatal uterine differentiatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
