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Lehmstedt–Tanasescu Reaction
The Lehmstedt–Tanasescu reaction is a method in organic chemistry for the organic synthesis of acridone derivatives (3) from a 2-nitrobenzaldehyde (1) and an arene compound (2):I Silberg. ''Rev Roum Chim'' 10 (1965) 1035 The reaction is named after two chemists who devoted part of their careers to research into this synthetic method, the German chemist Kurt Lehmstedt and the Romanian chemist Ion Tănăsescu (chemist), Ion Tănăsescu. Variations of the reaction name include Lehmsted–Tănăsescu reaction, Lehmsted–Tănăsescu acridone synthesis and Lehmsted–Tanasescu acridone synthesis. Reaction mechanism In the first step of the reaction mechanism the precursor molecule 2-nitrobenzaldehyde 4 is protonated, often by sulfuric acid, to intermediate 5, followed by an electrophile, electrophilic attack to benzene (other arenes can be used as well). The resulting benzhydrol 6 cyclisizes to 7 and finally to compound 8. Treatment of this intermediate with nitrous acid (sodium n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organic Chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; Greeves, N. and Warren, S. (2012) ''Organic Chemistry''. Oxford University Press. pp. 1–15. . Study of structure determines their structural formula. Study of properties includes physical and chemical properties, and evaluation of chemical reactivity to understand their behavior. The study of organic reactions includes the chemical synthesis of natural products, drugs, and polymers, and study of individual organic molecules in the laboratory and via theoretical ( in silico) study. The range of chemicals studied in organic chemistry includes hydrocarbons (compounds containing only carbon and hydrogen) as well as compounds based on carbon, but also containing other elements, especially oxygen, nitrogen, sulfur, phosphorus (included in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
