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Leonard Lowe
''Awakenings'' is a 1990 American biographical drama film written by Steven Zaillian, directed by Penny Marshall, and starring Robert De Niro, Robin Williams, Julie Kavner, Ruth Nelson, John Heard, Penelope Ann Miller, Peter Stormare and Max von Sydow. It is based on Oliver Sacks's 1973 nonfiction memoir ''Awakenings''. The film tells the story of the fictional neurologist Dr. Malcolm Sayer (Williams), whose character is based on Sacks. In 1969, Sayer discovers the beneficial effects of the drug L-DOPA and administers the drug to catatonic patients who survived the 1919–1930 epidemic of encephalitis lethargica. The patients—among them the focal character Leonard Lowe (De Niro)—are awakened after decades and must therefore try to acclimate to life in a new and unfamiliar time. The film is produced by Walter Parkes and Lawrence Lasker, who first encountered Sacks's book as undergraduates at Yale University. Released on December 12, 1990, ''Awakenings'' was a critical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penny Marshall
Carole Penny MarshallBorn Carole Penny Marshall in 1943, as per ''My Mother Was Nuts, a Memoir'', p. 10; . Copyright 2012 (October 15, 1943 – December 17, 2018) was an American actress, film director, and producer. She is best known for her role as Laverne DeFazio on the television sitcom ''Laverne & Shirley'' (1976–1983), receiving three nominations for the Golden Globe Award for Best Actress – Television Series Musical or Comedy for her portrayal. Marshall made her directorial debut with ''Jumpin' Jack Flash (film), Jumpin' Jack Flash'' (1986) before directing ''Big (film), Big'' (1988), which became the first film directed by a woman to gross more than $100 million at the U.S. box office. Her subsequent directing credits included ''Awakenings'' (1990), which was nominated for the Academy Award for Best Picture, ''A League of Their Own'' (1992), ''Renaissance Man (film), Renaissance Man'' (1994), ''The Preacher's Wife'' (1996), and ''Riding in Cars with Boys'' (2001 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biographical Film
A biographical film or biopic () is a film that dramatizes the life of an actual person or group of people. Such films show the life of a historical person and the central character's real name is used. They differ from Docudrama, docudrama films and Historical drama, historical drama films in that they attempt to comprehensively tell a single person's life story or at least the most historically important years of their lives. Context Biopic scholars include George F. Custen of the College of Staten Island and Dennis P. Bingham of Indiana University–Purdue University Indianapolis. Custen, in ''Bio/Pics: How Hollywood Constructed Public History'' (1992), regards the genre as having died with the Studio system, Hollywood studio era, and in particular, Darryl F. Zanuck. On the other hand, Bingham's 2010 study ''Whose Lives Are They Anyway? The Biopic as Contemporary Film Genre'' shows how it perpetuates as a codified genre using many of the same tropes used in the studio era that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York City
New York, often called New York City (NYC), is the most populous city in the United States, located at the southern tip of New York State on one of the world's largest natural harbors. The city comprises five boroughs, each coextensive with a respective county. The city is the geographical and demographic center of both the Northeast megalopolis and the New York metropolitan area, the largest metropolitan area in the United States by both population and urban area. New York is a global center of finance and commerce, culture, technology, entertainment and media, academics, and scientific output, the arts and fashion, and, as home to the headquarters of the United Nations, international diplomacy. With an estimated population in 2024 of 8,478,072 distributed over , the city is the most densely populated major city in the United States. New York City has more than double the population of Los Angeles, the nation's second-most populous city. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academy Award For Best Adapted Screenplay
The Academy Award for Best Adapted Screenplay is the Academy Award for the best screenplay adapted from previously established material. The most frequently adapted media are novels, but other adapted narrative formats include stage plays, musicals, short stories, TV series, and other films and film characters. All sequels are also considered adaptations by this standard, being based on the story and characters of the original film. Prior to its current name, the award was known as the Academy Award for Best Screenplay Based On Material From Another Medium. The Best Adapted Screenplay category has been a part of the Academy Awards since their inception. Superlatives The first person to win twice in this category was Joseph L. Mankiewicz, who won the award in two consecutive years, 1949 and 1950. Others to win twice in this category include George Seaton, Robert Bolt (who also won in consecutive years), Francis Ford Coppola, Mario Puzo, Alvin Sargent, Ruth Prawer Jhabvala ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academy Award For Best Actor
The Academy Award for Best Actor is an award presented annually by the Academy of Motion Picture Arts and Sciences (AMPAS). It has been awarded since the 1st Academy Awards to an actor who has delivered an outstanding performance in a leading role in a film released that year. The award is traditionally presented by the previous year's Best Actress winner. However, in recent years, it has shifted towards being presented by previous years’ Best Actor winners instead. The Best Actor award has been presented 97 times, to 86 actors. The first winner was German actor Emil Jannings for his roles in '' The Last Command'' (1928) and '' The Way of All Flesh'' (1927). The most recent winner is Adrien Brody for '' The Brutalist'' (2024); he previously won the award for '' The Pianist'' (2002) at the age of 29, making him the category's youngest winner. The record for most wins is three, held by Daniel Day-Lewis, and ten other actors have won twice. The record for most nominatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academy Award For Best Picture
The Academy Award for Best Picture is one of the Academy Awards (also known as Oscars) presented annually by the Academy of Motion Picture Arts and Sciences (AMPAS) since the awards debuted in 1929. This award goes to the producers of the film and is the only category in which every member of the Academy is eligible to submit a nomination and vote on the final ballot. The Best Picture category is traditionally the final award of the night and is widely considered the most prestigious honor of the ceremony. The Grand Staircase columns at the Dolby Theatre in Hollywood, where the Academy Awards ceremonies have been held since 2002, showcase every film that has won the Best Picture title since the award's inception. There have been 611 films nominated for Best Picture and 97 winners. History Category name changes At the 1st Academy Awards ceremony held in 1929 (for films made in 1927 and 1928), there were two categories of awards that were each considered the top award of the ni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academy Awards
The Academy Awards, commonly known as the Oscars, are awards for artistic and technical merit in film. They are presented annually by the Academy of Motion Picture Arts and Sciences (AMPAS) in the United States in recognition of excellence in cinematic achievements as assessed by the Academy's voting membership. The Oscars are widely considered to be the most prestigious awards in the film industry. The major award categories, known as the Academy Awards of Merit, are presented during a live-televised Hollywood, Los Angeles, Hollywood ceremony in February or March. It is the oldest worldwide entertainment awards ceremony. The 1st Academy Awards were held in 1929. The 2nd Academy Awards, second ceremony, in 1930, was the first one broadcast by radio. The 25th Academy Awards, 1953 ceremony was the first one televised. It is the oldest of the EGOT, four major annual American entertainment awards. Its counterparts—the Emmy Awards for television, the Tony Awards for theater, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yale University
Yale University is a Private university, private Ivy League research university in New Haven, Connecticut, United States. Founded in 1701, Yale is the List of Colonial Colleges, third-oldest institution of higher education in the United States, and one of the nine colonial colleges chartered before the American Revolution. Yale was established as the Collegiate School in 1701 by Congregationalism in the United States, Congregationalist clergy of the Connecticut Colony. Originally restricted to instructing ministers in theology and sacred languages, the school's curriculum expanded, incorporating humanities and sciences by the time of the American Revolution. In the 19th century, the college expanded into graduate and professional instruction, awarding the first Doctor of Philosophy, PhD in the United States in 1861 and organizing as a university in 1887. Yale's faculty and student populations grew rapidly after 1890 due to the expansion of the physical campus and its scientif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Walter Parkes
Walter F. Parkes (born April 15, 1951) is an American producer, screenwriter, and media executive. The producer of more than 50 films, including the ''Men in Black'' series and '' Minority Report,'' he is the co-founder and co-chairman of Dreamscape Immersive. Parkes and his wife and business partner, producer Laurie MacDonald, helped to build DreamWorks, with Parkes the head of its motion picture division, and the two later moved to Amblin Entertainment, where Parkes served as president. He has been nominated for three Academy Awards, receiving his first nomination as the director/ producer of the 1975 documentary '' The California Reich''; his second for co-writing the original screenplay for '' WarGames''; and his third as a producer of '' Awakenings''. Parkes and MacDonald created the Parkes + Macdonald production company (P+M, P+M Image Nation) in 2010, collaborating on the productions of a number of films, including films that Amblin has released. Life and career Pa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Encephalitis Lethargica
Encephalitis lethargica (EL) is an atypical form of encephalitis. Also known as "von Economo Encephalitis", "sleeping sickness" or "sleepy sickness" (distinct from tsetse fly–transmitted sleeping sickness), it was first described in 1917 by neurologist Constantin von Economo and pathologist Jean-René Cruchet. The disease attacks the brain, leaving some victims in a statue-like condition, speechless and motionless. Between 1915 and 1926, an epidemic of encephalitis lethargica spread around the world. The exact number of people infected is unknown, but it is estimated that more than one million people contracted the disease during the epidemic, which directly caused more than 500,000 deaths. Most of those who survived never recovered their pre-morbid vigour. Signs and symptoms Encephalitis lethargica is characterized by high fever, sore throat, headache, lethargy, double vision, delayed physical and mental response, sleep inversion and catatonia. In severe cases, patients ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1919–1930 Encephalitis Lethargica Epidemic
The encephalitis lethargica epidemic lasted from around 1918 to 1930. The cause is still unknown. Though the cause was once attributed to the coinciding Spanish flu epidemic, modern research has disputed this claim. The mortality was as high as 20%. The epidemic is thought to have started in Romania during 1915, and the disease supposedly spread through the movement of the various troops during World War I. In 1917, it reached the epidemic status in Vienna, where it was first described. Disease outbreaks of encephalitis were first reported in England and France during 1918, followed by Canada, Central America, India, and the United States in 1919. Disease outbreaks were also reported in Germany and the Soviet Union during 1920. The epidemic peaked between 1920 and 1929, with an estimated one million people diagnosed with encephalitis lethargica during the epidemic period. The disease suddenly disappeared in the beginning of the 1930s. In the aftermath of the epidemic, many cases ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
L-DOPA
-DOPA, also known as -3,4-dihydroxyphenylalanine and used medically as levodopa, is made and used as part of the normal biology of some plants and animals, including humans. Humans, as well as a portion of the other animals that utilize -DOPA, make it via biosynthesis from the amino acid -tyrosine. -DOPA is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), which are collectively known as catecholamines. Furthermore, -DOPA itself mediates neurotrophic factor release by the brain and central nervous system. In some plant families (of the order Caryophyllales), -DOPA is the central precursor of a biosynthetic pathway that produces a class of pigments called betalains. -DOPA can be manufactured and in its pure form is sold as a drug with the '' levodopa''. As a drug, it is used in the treatment of Parkinson's disease and dopamine-responsive dystonia, as well as restless leg syndrome. -DOPA has a counter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
