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Koebner Phenomenon
The Koebner phenomenon or Köbner phenomenon (, ), also called the Koebner response or the isomorphic response, attributed to Heinrich Köbner, is the appearance of skin lesions on lines of trauma. The Koebner phenomenon may result from either a linear exposure or irritation. Conditions demonstrating linear lesions after a linear exposure to a causative agent include: molluscum contagiosum, warts and toxicodendron dermatitis (a dermatitis caused by a genus of plants including poison ivy). Warts and molluscum contagiosum lesions can be spread in linear patterns by self-scratching (" auto-inoculation"). Toxicodendron dermatitis lesions are often linear from brushing up against the plant. Causes of the Koebner phenomenon that are secondary to scratching rather than an infective or chemical cause include vitiligo, psoriasis, lichen planus, lichen nitidus, pityriasis rubra pilaris, and keratosis follicularis (Darier disease). Definition The Koebner phenomenon describes s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heinrich Köbner
Heinrich Koebner (German spelling Köbner); (2 December 1838 – 3 September 1904) was a German Jew, German-Jewish dermatologist born in Breslau. He studied medicine in Berlin, earning his doctorate in 1859 at Breslau. Afterwards he performed hospital duties in Vienna under Ferdinand von Hebra (1816–1880) and in Paris with Alfred Hardy (dermatologist), Alfred Hardy (1811–1893). In 1876 he became director of the policlinic for syphilis and diseases of the skin at the University of Breslau. In 1884 he established a new policlinic in Berlin, where he provided classes for physicians. Koebner phenomenon Koebner was a renowned dermatologist known for his research of psoriasis, epidermolysis bullosa simplex and various fungus, fungal disorders. He is best known for the eponymous "Koebner Phenomenon, Koebner phenomenon", also known as isomorphic phenomenon. The Koebner phenomenon is the development of isomorphism (other), isomorphic pathology, pathologic lesions ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Flat Warts
Flat warts, technically known as verruca plana, are reddish-brown or flesh-colored, slightly raised, flat-surfaced, well-demarcated papule of 2 to 5 mm in diameter. Upon close inspection, these lesions have a surface that is "finely verrucous".Lookingbill, Donald, et al. ''Principles of Dermatology''. Saunders. 2000. Pages 68-69. . Most often, these lesions affect the hands, legs, or face, and a linear arrangement is not uncommon. At histopathology, flat warts have cells with prominent perinuclear vacuolization around pyknotic, basophilic Basophilic is a technical term used by pathologists. It describes the appearance of cells, tissues and cellular structures as seen through the microscope after a histological section has been stained with a basic dye. The most common such dye ..., centrally located nuclei that may be located in the granular layer. Last Update: May 13, 2019. These are referred to as "owl's eye cells." Additional images Micrograph of a flat wart.jpg, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyoderma Gangrenosum
Pyoderma gangrenosum is a rare, Inflammation, inflammatory skin disease where painful pustules or skin condition, nodules become ulcer (dermatology), ulcers that progressively grow. Pyoderma gangrenosum is not infectious. Treatments may include corticosteroids, ciclosporin, infliximab, or canakinumab. The disease was identified in 1930. It affects approximately 1 person in 100,000 in the population. Though it can affect people of any age, it mostly affects people in their 40s and 50s. Types There are two main types of pyoderma gangrenosum: * the 'typical' ulcerative form, which occurs in the legs * an 'atypical' form that is more superficial and occurs in the hands and other parts of the body Other variations are: * Peristomal pyoderma gangrenosum comprises 15% of all cases of pyoderma * Bullous pyoderma gangrenosum * Pustular pyoderma gangrenosum * wikt:vegetative, Vegetative pyoderma gangrenosum Presentation Associations The following are conditions commonly associated wit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Post Kala Azar Dermal Leishmaniasis
Leishmaniasis is a wide array of clinical manifestations caused by protozoal parasites of the Trypanosomatida genus ''Leishmania''. It is generally spread through the bite of phlebotomine sandflies, ''Phlebotomus'' and ''Lutzomyia'', and occurs most frequently in the tropics and sub-tropics of Africa, Asia, the Americas, and southern Europe. The disease can present in three main ways: cutaneous, mucocutaneous, or visceral. The cutaneous form presents with skin ulcers, while the mucocutaneous form presents with ulcers of the skin, mouth, and nose. The visceral form starts with skin ulcers and later presents with fever, low red blood cell count, and enlarged spleen and liver. Infections in humans are caused by more than 20 species of ''Leishmania''. Risk factors include poverty, malnutrition, deforestation, and urbanization. All three types can be diagnosed by seeing the parasites under microscopy. Additionally, visceral disease can be diagnosed by blood tests. Leishmanias ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cutaneous Leishmaniasis
Cutaneous leishmaniasis is the most common form of leishmaniasis affecting humans. It is a skin infection caused by a Trypanosomatid, single-celled parasite that is Vector (epidemiology), transmitted by the bite of a Phlebotominae, phlebotomine sand fly. About 30 species of ''Leishmania'' may cause skin, cutaneous leishmaniasis. This disease is considered to be a zoonosis (an infectious disease that is naturally transmissible from animals to humans), with the exception of ''Leishmania tropica'', which is often an anthroponotic disease (an infectious disease that is naturally transmissible from humans to vertebrate animals). Signs and symptoms Post kala-azar dermal leishmaniasis Post-kala-azar dermal leishmaniasis (PKDL) is a recurrence of Visceral leishmaniasis, ''kala-azar'' that may appear on the skin of affected individuals months and up to 20 years after being partially treated, untreated, or even in those considered adequately treated. In Sudan, they can be demonstrated in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Systemic-onset Juvenile Idiopathic Arthritis
Systemic-onset juvenile idiopathic arthritis (sJIA), also known as Still disease, Still's disease, and systemic juvenile idiopathic arthritis, is a subtype of juvenile idiopathic arthritis (JIA) that is distinguished by arthritis, a characteristic erythematous skin rash, and remitting fever. Fever is a common symptom in patients with sJIA, characterized by sudden temperature rise above 39 °C and then a sudden drop. Over 80% of patients have a salmon-colored macular or maculopapular rash, which can be migratory and nonpruritic. Arthritis can develop weeks, months, or even years after onset and can affect various joints. SJIA is characterized by splenic and lymph node enlargements, with prominent symmetrical lymphadenopathy. Pericardial involvement is common, with 81% of children with active systemic symptoms having abnormal echocardiographic findings and 36% having an effusion or pericardial thickening. Around one-third of children with sJIA have occult macrophage activation s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA), formerly known as juvenile rheumatoid arthritis (JRA), is the most common chronic rheumatic disease of childhood, affecting approximately 3.8 to 400 out of 100,000 children. ''Juvenile'', in this context, refers to disease onset before 16 years of age, while ''idiopathic'' refers to a condition with no defined cause, and ''arthritis'' is inflammation within the joint. JIA is an autoimmune, noninfective, inflammatory joint disease, the cause of which remains poorly understood. It is characterised by chronic joint inflammation. JIA is a subset of childhood arthritis, but unlike other, more transient forms of childhood arthritis, JIA persists for at least six weeks, and in some children is a lifelong condition. It differs significantly from forms of arthritis commonly seen in adults (osteoarthritis, rheumatoid arthritis), in terms of cause, disease associations, and prognosis. The prognosis for children with JIA has improved dramatically over re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lupus
Lupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary among people and may be mild to severe. Common symptoms include painful and swollen joints, fever, chest pain, hair loss, mouth ulcers, swollen lymph nodes, feeling tired, and a red rash which is most commonly on the face. Often there are periods of illness, called flares, and periods of remission during which there are few symptoms. Children up to 18 years old develop a more severe form of SLE termed childhood-onset systemic lupus erythematosus. The cause of SLE is not clear. It is thought to involve a combination of genetics and environmental factors. Among identical twins, if one is affected there is a 24% chance the other one will also develop the disease. Female sex hormones, sunlight, smoking, vitamin D deficiency, and certain infections are also believed to increase a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Necrobiosis Lipoidica
Necrobiosis Lipoidica is a rare, chronic skin condition predominantly associated with diabetes mellitus (known as necrobiosis lipoidica diabeticorum or NLD). It can occur in individuals with rheumatoid arthritis or without any underlying conditions (idiopathic) and can also be displayed in patients with obesity, hypertension, celiac disease, and metabolic syndrome. About a quarter of Necrobiosis Lipoidica is associated with diabetes mellitus. The broader overarching definition of necrobiosis is a gradual physiological death of a cell. It can be caused by basophilia, erythema, or a tumor. As a dermapathology term, it refers to altered collagen or altered dermal connective tissue. Necrobiosis Lipoidica is linked to microvascular damage and collagen degeneration. The exact cause of this condition is not known, but it involves collagen degeneration and a granulomatous response in the layer of the skin called the dermis, often affecting the deeper fat layer and thickening dermal blood ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kaposi Sarcoma
Kaposi's sarcoma (KS) is a type of cancer that can form masses on the skin, in lymph nodes, in the mouth, or in other organs. The skin lesions are usually painless, purple and may be flat or raised. Lesions can occur singly, multiply in a limited area, or may be widespread. Depending on the sub-type of disease and level of immune suppression, KS may worsen either gradually or quickly. Except for classic KS where there is generally no immune suppression, KS is caused by a combination of immune suppression (such as due to HIV/AIDS) and infection by Human herpesvirus 8 (HHV8 – also called KS-associated herpesvirus (KSHV)). Classic, endemic, immunosuppression therapy-related (also known as iatrogenic), and epidemic (also known as AIDS-related) sub-types are all described. Classic KS tends to affect older men in regions where KSHV is highly prevalent (Mediterranean, Eastern Europe, Middle East), is usually slow-growing, and most often affects only the legs. Endemic KS is most comm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elastosis Perforans Serpiginosa
Elastosis perforans serpiginosa is a unique perforating disorder characterized by transepidermal elimination of elastic fibers and distinctive clinical lesions, which are serpiginous in distribution and can be associated with specific diseases.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). Page 1041. McGraw-Hill. . File:Histopathology of elastosis perforans serpiginosa.jpg, Histopathology of elastosis perforans serpiginosa: Degenerated elastic fibers and transepidermal perforating canals (arrow points at one of them) File:Autosomal dominant - en.svg, This condition is inherited in an autosomal dominant manner. See also * List of cutaneous conditions Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the Human body, body and composed of Human skin, skin, hair, Nail (anatomy), nails, and related muscle and glands. The major function o ... * Poikiloderma vasculare atrophicans ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
