Heinrich Koebner (German spelling Köbner); (2 December 1838 – 3 September 1904) was a

German-Jewish The history of the Jews in Germany goes back at least to the year 321 CE, and continued through the Early Middle Ages (5th to 10th centuries CE) and High Middle Ages (c. 1000–1299 CE) when Jewish immigrants founded the Ashkenazi Jewish commu ...

dermatologist Dermatology is the branch of medicine dealing with the skin.''Random House Webster's Unabridged Dictionary.'' Random House, Inc. 2001. Page 537. . It is a speciality with both medical and surgical aspects. A dermatologist is a specialist medi ...

born in Breslau. He studied medicine in

Berlin Berlin ( ; ) is the Capital of Germany, capital and largest city of Germany, by both area and List of cities in Germany by population, population. With 3.7 million inhabitants, it has the List of cities in the European Union by population withi ...

, earning his doctorate in 1859 at Breslau. Afterwards he performed hospital duties in

Vienna Vienna ( ; ; ) is the capital city, capital, List of largest cities in Austria, most populous city, and one of Federal states of Austria, nine federal states of Austria. It is Austria's primate city, with just over two million inhabitants. ...

under Ferdinand von Hebra (1816–1880) and in

Paris Paris () is the Capital city, capital and List of communes in France with over 20,000 inhabitants, largest city of France. With an estimated population of 2,048,472 residents in January 2025 in an area of more than , Paris is the List of ci ...

with Alfred Hardy (1811–1893). In 1876 he became director of the policlinic for

syphilis Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms depend on the stage it presents: primary, secondary, latent syphilis, latent or tertiary. The prim ...

and diseases of the skin at the

University of Breslau A university () is an educational institution, institution of tertiary education and research which awards academic degrees in several Discipline (academia), academic disciplines. ''University'' is derived from the Latin phrase , which roughly ...

. In 1884 he established a new policlinic in Berlin, where he provided classes for physicians.

Koebner phenomenon

Koebner was a renowned dermatologist known for his research of

psoriasis Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small localized patches to complete b ...

epidermolysis bullosa simplex Epidermolysis bullosa simplex (EBS) is a disorder resulting from mutations in the genes encoding keratin 5 or keratin 14.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. . It is one of the major f ...

and various

fungal A fungus (: fungi , , , or ; or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as one of the tradit ...

disorders. He is best known for the eponymous "

Koebner phenomenon The Koebner phenomenon or Köbner phenomenon (, ), also called the Koebner response or the isomorphic response, attributed to Heinrich Köbner, is the appearance of skin lesions on lines of trauma. The Koebner phenomenon may result from either ...

", also known as isomorphic phenomenon. The Koebner phenomenon is the development of

isomorphic In mathematics, an isomorphism is a structure-preserving mapping or morphism between two structures of the same type that can be reversed by an inverse mapping. Two mathematical structures are isomorphic if an isomorphism exists between the ...

pathologic ''Pathologic'' ( rus, Мор. Утопия, Mor. Utopiya, ˈmor ʊˈtopʲɪjə, , More. Utopia – a pun on Thomas More's ''Utopia (More book), Utopia'' and the Russian word for "plague") is a 2005 Survival game, survival game developed by Russ ...

lesion A lesion is any damage or abnormal change in the tissue of an organism, usually caused by injury or diseases. The term ''Lesion'' is derived from the Latin meaning "injury". Lesions may occur in both plants and animals. Types There is no de ...

s in the traumatized "uninvolved skin" of persons who have

cutaneous Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation. Other animal coverings, such as the arthropod exoskeleton, have different d ...

diseases such as psoriasis. In other words, if a person has psoriasis, an injury is followed by new psoriatic lesions on the injured but otherwise normal (formerly non-psoriatic) skin, and these new lesions are similar to those of the diseased (originally psoriatic) skin in a clinical and

histopathological Histopathology (compound of three Greek language, Greek words: 'tissue', 'suffering', and ''-logy, -logia'' 'study of') is the light microscope, microscopic examination of Tissue (biology), tissue in order to study the manifestations of dis ...

sense. In 1872, Koebner explained this phenomenon to the Silesian Society for National Culture, by presenting a case in which years after the appearance of an isolated

plaque Plaque may refer to: Commemorations or awards * Commemorative plaque, a plate, usually fixed to a wall or other vertical surface, meant to mark an event, person, etc. * Memorial Plaque (medallion), issued to next-of-kin of dead British military p ...

of psoriasis, several "traumatic" events in various areas of the body (tattoos, animal bite,

suppuration Pus is an exudate, typically white-yellow, yellow, or yellow-brown, formed at the site of inflammation during infections, regardless of cause. An accumulation of pus in an enclosed tissue space is known as an abscess, whereas a visible collec ...

from

lymphadenitis Lymphadenopathy or adenopathy is a disease of the lymph nodes, in which they are abnormal in size or consistency. Lymphadenopathy of an inflammatory type (the most common type) is lymphadenitis, producing swollen or enlarged lymph nodes. In cl ...

, et al.) caused new outbreaks of psoriasis at exactly the same locations, in the same shape as the injured skin. "Koebnerization" may also occur with skin disorders such as

vitiligo Vitiligo (, ) is a chronic autoimmune disorder that causes patches of skin to lose pigment or color. The cause of vitiligo is unknown, but it may be related to immune system changes, genetic factors, stress, or sun exposure, and susceptibili ...

and

lichen planus Lichen planus (LP) is a chronic inflammatory and autoimmune disease that affects the skin, nails, hair, and mucous membranes. It is not an actual lichen, but is named for its appearance. It is characterized by polygonal, flat-topped, violaceous p ...

. The following terms are derived from Koebner's name, and are still used by modern dermatologists: * "

koebnerization The Koebner phenomenon or Köbner phenomenon (, ), also called the Koebner response or the isomorphic response, attributed to Heinrich Köbner, is the appearance of skin lesions on lines of trauma. The Koebner phenomenon may result from either a ...

": word to describe the isomorphic process taking place. * " reverse koebnerization": is seen when an area of psoriasis clears; an isomorphic nonresponse. Also referred to as the "

Renbök phenomenon In the field of dermatology, the Renbök phenomenon is a phenomenon where one skin condition inhibits another. It is also known as the reverse Koebner phenomenon. The term was first used by Happle et al. in 1991. The word "Renbök" is a neologism, m ...

", with the term "Renbök" being the reverse spelling of "Köbner".JAMA Dermatology
Renbök Phenomenon and Contact Sensitization in a Patient With Alopecia Universalis * " pseudo-koebnerization": is used to describe the spread of an infectious agent such as

warts Warts are non-cancerous viral growths usually occurring on the hands and feet but which can also affect other locations, such as the genitals or face. One or many warts may appear. They are distinguished from cancerous tumors as they are caus ...

and

molluscum contagiosum Molluscum contagiosum (MC), sometimes called water warts, is a viral infection of the skin that results in small raised pink lesions with a dimple in the center. They may become itchy or sore, and occur singularly or in groups. Any area of the ...

Koebner phenomenon

References

Further reading