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József Knoll
József Knoll (May 30, 1925 – April 17, 2018), or Joseph Knoll, was a Hungarian psychopharmacologist known for developing the antiparkinsonian and antidepressant drug selegiline (L-deprenyl). He developed selegiline in the 1960s and subsequently studied the drug and related agents for many decades. Knoll also developed the concepts of monoaminergic activity enhancers (MAEs) and the mesencephalic enhancer regulation system, among other contributions. MAEs developed by Knoll and colleagues include selegiline, benzofuranylpropylaminopentane (BPAP), and phenylpropylaminopentane (PPAP), among others. During his scientific career, Knoll published 894papers and was the originator of 55patents. As of 2018, his papers had been cited more than 10,000times. He is described as one of the best-known Hungarian pharmacologists. Knoll is known for having extensively researched and promoted selegiline for claimed drive- and longevity Longevity may refer to especially long-lived members ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hungary
Hungary is a landlocked country in Central Europe. Spanning much of the Pannonian Basin, Carpathian Basin, it is bordered by Slovakia to the north, Ukraine to the northeast, Romania to the east and southeast, Serbia to the south, Croatia and Slovenia to the southwest, and Austria to the west. Hungary lies within the drainage basin of the Danube, Danube River and is dominated by great lowland plains. It has a population of 9.6 million, consisting mostly of ethnic Hungarians, Hungarians (Magyars) and a significant Romani people in Hungary, Romani minority. Hungarian language, Hungarian is the Languages of Hungary, official language, and among Languages of Europe, the few in Europe outside the Indo-European languages, Indo-European family. Budapest is the country's capital and List of cities and towns of Hungary, largest city, and the dominant cultural and economic centre. Prior to the foundation of the Hungarian state, various peoples settled in the territory of present-day Hun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monoaminergic Activity Enhancer
Monoaminergic activity enhancers (MAE), also known as catecholaminergic/serotonergic activity enhancers (CAE/SAE), are a class of drugs that enhance the action potential-evoked release of monoamine neurotransmitters in the nervous system. MAEs are distinct from monoamine releasing agents (MRAs) like amphetamine and fenfluramine in that they do not induce the release of monoamines from synaptic vesicles but rather potentiate only nerve impulse propagation-mediated monoamine release. That is, MAEs increase the amounts of monoamine neurotransmitters released by neurons per electrical impulse. MAEs have been shown to significantly enhance nerve impulse-mediated dopamine release in the striatum, substantia nigra, and olfactory tubercle; norepinephrine release from the locus coeruleus; and/or serotonin release from the raphe nucleus in rodent studies. Some MAEs are selective for effects on some of these neurotransmitters but not on others. The maximal impacts of MAEs on brain monoam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2018 Deaths
This is a list of lists of deaths of notable people, organized by year. New deaths articles are added to their respective month (e.g., Deaths in ) and then linked below. 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 Earlier years ''Deaths in years earlier than this can usually be found in the main articles of the years.'' See also * Lists of deaths by day * Deaths by year (category) {{DEFAULTSORT:deaths by year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1925 Births
Events January * January 1 – The Syrian Federation is officially dissolved, the State of Aleppo and the State of Damascus having been replaced by the State of Syria (1925–1930), State of Syria. * January 3 – Benito Mussolini makes a pivotal speech in the Italian Chamber of Deputies (Italy), Chamber of Deputies which will be regarded by historians as the beginning of his dictatorship. * January 5 – Nellie Tayloe Ross becomes the first female governor (Wyoming) in the United States. Twelve days later, Ma Ferguson becomes first female governor of Texas. * January 25 – Hjalmar Branting resigns as Prime Minister of Sweden because of ill health, and is replaced by the minister of trade, Rickard Sandler. * January 27–February 1 – The 1925 serum run to Nome (the "Great Race of Mercy") relays diphtheria antitoxin by dog sled across the U.S. Territory of Alaska to combat an epidemic. February * February 25 – Art Gillham records (for Columbia Re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Longevity
Longevity may refer to especially long-lived members of a population, whereas ''life expectancy'' is defined Statistics, statistically as the average number of years remaining at a given age. For example, a population's life expectancy at birth is the same as the average age at death for all people born in the same year (in the case of Cohort (statistics), cohorts). Longevity studies may involve putative methods to extend life. Longevity has been a topic not only for the scientific community but also for writers of Hyperborei, travel, science fiction, and utopian novels. The legendary fountain of youth appeared in the work of the Ancient Greek historian Herodotus. There are difficulties in authenticating the longest human maximum life span, life span, owing to inaccurate or incomplete birth statistics. Fiction, legend, and folklore have proposed or claimed life spans in the past or future vastly longer than those verified by modern standards, and longevity narratives and unverif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Motivation
Motivation is an mental state, internal state that propels individuals to engage in goal-directed behavior. It is often understood as a force that explains why people or animals initiate, continue, or terminate a certain behavior at a particular time. It is a complex phenomenon and its precise definition is disputed. It contrasts with #Amotivation and akrasia, amotivation, which is a state of apathy or listlessness. Motivation is studied in fields like psychology, neuroscience, motivation science, and philosophy. Motivational states are characterized by their direction, Motivational intensity, intensity, and persistence. The direction of a motivational state is shaped by the goal it aims to achieve. Intensity is the strength of the state and affects whether the state is translated into action and how much effort is employed. Persistence refers to how long an individual is willing to engage in an activity. Motivation is often divided into two phases: in the first phase, the indi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenylpropylaminopentane
1-Phenyl-2-propylaminopentane (PPAP), also known as α,''N''-dipropylphenethylamine (DPPEA) and by the developmental code name MK-306, is an experimental drug related to selegiline which acts as a catecholaminergic activity enhancer (CAE). PPAP is a CAE and enhances the nerve impulse propagation-mediated release of norepinephrine and dopamine. It produces psychostimulant-like effects in animals. The drug is a phenethylamine and amphetamine derivative and was derived from selegiline. PPAP was first described in the literature in 1988 and in the first major paper in 1992. It led to the development of the improved monoaminergic activity enhancer (MAE) benzofuranylpropylaminopentane (BPAP) in 1999. PPAP was a reference compound for studying the MAE system for many years. However, it was superseded by BPAP, which is more potent, selective, and also enhances serotonin. There has been interest in PPAP for potential clinical use in humans, including in the treatment of depression, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzofuranylpropylaminopentane
(–)-Benzofuranylpropylaminopentane (BPAP; developmental code name FPFS-1169) is an experimental drug related to selegiline which acts as a monoaminergic activity enhancer (MAE). It is orally active in animals. BPAP is a highly potent MAE and enhances the nerve impulse propagation-mediated release of serotonin, norepinephrine, and dopamine. At much higher concentrations, BPAP is also a monoamine reuptake inhibitor, specifically of dopamine and norepinephrine and to a much lesser extent of serotonin. BPAP produces psychostimulant-like effects in animals, with these effects mediated by its MAE actions. The drug is a substituted benzofuran derivative and tryptamine relative structurally related to phenylpropylaminopentane (PPAP). BPAP was first described in 1999. There has been interest in BPAP for potential clinical use in humans, including in the treatment of Parkinson's disease, Alzheimer's disease, and depression. There has also been interest in BPAP to help slow aging. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monoaminergic Activity Enhancer
Monoaminergic activity enhancers (MAE), also known as catecholaminergic/serotonergic activity enhancers (CAE/SAE), are a class of drugs that enhance the action potential-evoked release of monoamine neurotransmitters in the nervous system. MAEs are distinct from monoamine releasing agents (MRAs) like amphetamine and fenfluramine in that they do not induce the release of monoamines from synaptic vesicles but rather potentiate only nerve impulse propagation-mediated monoamine release. That is, MAEs increase the amounts of monoamine neurotransmitters released by neurons per electrical impulse. MAEs have been shown to significantly enhance nerve impulse-mediated dopamine release in the striatum, substantia nigra, and olfactory tubercle; norepinephrine release from the locus coeruleus; and/or serotonin release from the raphe nucleus in rodent studies. Some MAEs are selective for effects on some of these neurotransmitters but not on others. The maximal impacts of MAEs on brain monoam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Košice
Košice is the largest city in eastern Slovakia. It is situated on the river Hornád at the eastern reaches of the Slovak Ore Mountains, near the border with Hungary. With a population of approximately 230,000, Košice is the second-largest city in Slovakia, after the capital Bratislava. Being the economic and cultural centre of eastern Slovakia, Košice is the seat of the Košice Region and Košice Self-governing Region, it belongs to the :sk:Košicko-prešovská aglomerácia, Košice-Prešov agglomeration, and is home to the Constitutional Court of Slovakia, Slovak Constitutional Court, three universities, various dioceses, and many museums, galleries, and theatres. In 2013, Košice was the European Capital of Culture, together with Marseille, France. Košice is an important industrial centre of Slovakia, and the U. S. Steel Košice, s.r.o., U.S. Steel Košice steel mill is the largest employer in the city. The town has extensive railway connections and an Košice Internationa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Selegiline
Selegiline, also known as L-deprenyl and sold under the brand names Eldepryl, Zelapar, and Emsam among others, is a medication which is used in the treatment of Parkinson's disease and major depressive disorder. It has also been studied and used off-label for a variety of other indications, but has not been formally approved for any other use. The medication, in the form licensed for depression, has modest effectiveness for this condition that is similar to that of other antidepressants. Selegiline is provided as a swallowed tablet or capsule or an orally disintegrating tablet (ODT) for Parkinson's disease and as a patch applied to skin for depression. Side effects of selegiline occurring more often than with placebo include insomnia, dry mouth, dizziness, anxiety, abnormal dreams, and application site reactions (with the patch form), among others. At high doses, selegiline has the potential for dangerous food and drug interactions, such as tyramine-related hypertens ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug
A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via insufflation (medicine), inhalation, drug injection, injection, smoking, ingestion, absorption (skin), absorption via a dermal patch, patch on the skin, suppository, or sublingual administration, dissolution under the tongue. In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect. A pharmaceutical drug, also called a medication or medicine, is a chemical substance used to pharmacotherapy, treat, cure, preventive healthcare, prevent, or medical diagnosis, diagnose a disease or to promote well-being. Traditionally drugs were obtained through extraction from medicinal plants, but more recently also by organic synthesis. Pharmaceutical drugs may be used for a limited duration, or on a re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
