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ICIM Braşov
In statistical genetics, inclusive composite interval mapping (ICIM) has been proposed as an approach to QTL (quantitative trait locus) mapping for populations derived from bi-parental crosses. QTL mapping is based on genetic linkage map and phenotypic data to attempt to locate individual genetic factors on chromosomes and to estimate their genetic effects. Additive and dominance QTL mapping Two genetic assumptions used in ICIM are (1) the genotypic value of an individual is the summation of effects from all genes affecting the trait of interest; and (2) linked QTL are separated by at least one blank marker interval. Under the two assumptions, they proved that additive effect of the QTL located in a marker interval can be completely absorbed by the regression coefficients of the two flanking markers, while the QTL dominance effect causes marker dominance effects, as well as additive by additive and dominance by dominance interactions between the two flanking markers. By including ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Statistical Genetics
Statistical genetics is a scientific field concerned with the development and application of statistical methods for drawing inferences from genetic data. The term is most commonly used in the context of human genetics. Research in statistical genetics generally involves developing theory or methodology to support research in one of three related areas: *population genetics Population genetics is a subfield of genetics that deals with genetic differences within and among populations, and is a part of evolutionary biology. Studies in this branch of biology examine such phenomena as Adaptation (biology), adaptation, s ... - Study of evolutionary processes affecting genetic variation between organisms * genetic epidemiology - Studying effects of genes on diseases * quantitative genetics - Studying the effects of genes on 'normal' phenotypes Statistical geneticists tend to collaborate closely with geneticists, molecular biologists, clinicians and bioinformaticians. Statistic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
QTL Mapping
A quantitative trait locus (QTL) is a locus (section of DNA) that correlates with variation of a quantitative trait in the phenotype of a population of organisms. QTLs are mapped by identifying which molecular markers (such as SNPs or AFLPs) correlate with an observed trait. This is often an early step in identifying the actual genes that cause the trait variation. Definition A quantitative trait locus (QTL) is a region of DNA which is associated with a particular phenotypic trait, which varies in degree and which can be attributed to polygenic effects, i.e., the product of two or more genes, and their environment. . These QTLs are often found on different chromosomes. The number of QTLs which explain variation in the phenotypic trait indicates the genetic architecture of a trait. It may indicate that plant height is controlled by many genes of small effect, or by a few genes of large effect. Typically, QTLs underlie continuous traits (those traits which vary continuously, e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosome
A chromosome is a package of DNA containing part or all of the genetic material of an organism. In most chromosomes, the very long thin DNA fibers are coated with nucleosome-forming packaging proteins; in eukaryotic cells, the most important of these proteins are the histones. Aided by chaperone proteins, the histones bind to and condense the DNA molecule to maintain its integrity. These eukaryotic chromosomes display a complex three-dimensional structure that has a significant role in transcriptional regulation. Normally, chromosomes are visible under a light microscope only during the metaphase of cell division, where all chromosomes are aligned in the center of the cell in their condensed form. Before this stage occurs, each chromosome is duplicated ( S phase), and the two copies are joined by a centromere—resulting in either an X-shaped structure if the centromere is located equatorially, or a two-armed structure if the centromere is located distally; the jo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genotype
The genotype of an organism is its complete set of genetic material. Genotype can also be used to refer to the alleles or variants an individual carries in a particular gene or genetic location. The number of alleles an individual can have in a specific gene depends on the number of copies of each chromosome found in that species, also referred to as ploidy. In diploid species like humans, two full sets of chromosomes are present, meaning each individual has two alleles for any given gene. If both alleles are the same, the genotype is referred to as Zygosity, homozygous. If the alleles are different, the genotype is referred to as heterozygous. Genotype contributes to phenotype, the observable traits and characteristics in an individual or organism. The degree to which genotype affects phenotype depends on the trait. For example, the petal color in a pea plant is exclusively determined by genotype. The petals can be purple or white depending on the alleles present in the pea plan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of Gene product, RNA or protein from a gene), DNA is first transcription (biology), copied into RNA. RNA can be non-coding RNA, directly functional or be the intermediate protein biosynthesis, template for the synthesis of a protein. The transmission of genes to an organism's offspring, is the basis of the inheritance of phenotypic traits from one generation to the next. These genes make up different DNA sequences, together called a genotype, that is specific to every given individual, within the gene pool of the population (biology), population of a given species. The genotype, along with environmental and developmental factors, ultimately determines the phenotype ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linear Model
In statistics, the term linear model refers to any model which assumes linearity in the system. The most common occurrence is in connection with regression models and the term is often taken as synonymous with linear regression model. However, the term is also used in time series analysis with a different meaning. In each case, the designation "linear" is used to identify a subclass of models for which substantial reduction in the complexity of the related statistical theory is possible. Linear regression models For the regression case, the statistical model is as follows. Given a (random) sample (Y_i, X_, \ldots, X_), \, i = 1, \ldots, n the relation between the observations Y_i and the independent variables X_ is formulated as :Y_i = \beta_0 + \beta_1 \phi_1(X_) + \cdots + \beta_p \phi_p(X_) + \varepsilon_i \qquad i = 1, \ldots, n where \phi_1, \ldots, \phi_p may be nonlinear functions. In the above, the quantities \varepsilon_i are random variables representing err ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome
A genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of junk DNA with no evident function. Almost all eukaryotes have mitochondrial DNA, mitochondria and a small mitochondrial genome. Algae and plants also contain chloroplast DNA, chloroplasts with a chloroplast genome. The study of the genome is called genomics. The genomes of many organisms have been Whole-genome sequencing, sequenced and various regions have been annotated. The first genome to be sequenced was that of the virus φX174 in 1977; the first genome sequence of a prokaryote (''Haemophilus influenzae'') was published in 1995; the yeast (''Saccharomyces cerevisiae'') genome was the first eukaryotic genome to be sequenced in 1996. The Human Genome Project ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stepwise Regression
In statistics, stepwise regression is a method of fitting regression models in which the choice of predictive variables is carried out by an automatic procedure. In each step, a variable is considered for addition to or subtraction from the set of explanatory variables based on some prespecified criterion. Usually, this takes the form of a forward, backward, or combined sequence of ''F''-tests or ''t''-tests. The frequent practice of fitting the final selected model followed by reporting estimates and confidence intervals without adjusting them to take the model building process into account has led to calls to stop using stepwise model building altogetherFlom, P. L. and Cassell, D. L. (2007) "Stopping stepwise: Why stepwise and similar selection methods are bad, and what you should use," NESUG 2007. or to at least make sure model uncertainty is correctly reflected by using prespecified, automatic criteria together with more complex standard error estimates that remain unbiased. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coefficient
In mathematics, a coefficient is a Factor (arithmetic), multiplicative factor involved in some Summand, term of a polynomial, a series (mathematics), series, or any other type of expression (mathematics), expression. It may be a Dimensionless quantity, number without units, in which case it is known as a numerical factor. It may also be a constant (mathematics), constant with units of measurement, in which it is known as a constant multiplier. In general, coefficients may be any mathematical expression, expression (including Variable (mathematics), variables such as , and ). When the combination of variables and constants is not necessarily involved in a product (mathematics), product, it may be called a ''parameter''. For example, the polynomial 2x^2-x+3 has coefficients 2, −1, and 3, and the powers of the variable x in the polynomial ax^2+bx+c have coefficient parameters a, b, and c. A , also known as constant term or simply constant, is a quantity either implicitly attach ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Soybean
The soybean, soy bean, or soya bean (''Glycine max'') is a species of legume native to East Asia, widely grown for its edible bean. Soy is a staple crop, the world's most grown legume, and an important animal feed. Soy is a key source of food, useful both for its protein and oil content. Soybean oil is widely used in cooking, as well as in industry. Traditional unfermented food uses of soybeans include edamame, as well as soy milk, from which tofu and tofu skin are made. Fermented soy foods include soy sauce, fermented bean paste, nattō, and tempeh. Fat-free (defatted) soybean meal is a significant and cheap source of protein for animal feeds and many packaged meals. For example, soybean products, such as textured vegetable protein (TVP), are ingredients in many meat and dairy substitutes. Soy based foods are traditionally associated with East Asian cuisines, and still constitute a major part of East Asian diets, but processed soy products are increasingly used ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nested Association Mapping
Nested association mapping (NAM) is a technique designed by the labs of Edward BucklerJames Holland anfor identifying and dissecting the genetic architecture of complex traits in corn (''Zea mays''). It is important to note that nested association mapping (unlike association mapping) is a specific technique that cannot be performed outside of a specifically designed population such as the Maize NAM population, the details of which are described below. Theory behind NAM NAM was created as a means of combining the advantages and eliminating the disadvantages of two traditional methods for identifying quantitative trait loci: linkage analysis and association mapping. Linkage analysis depends upon recent genetic recombination between two different plant lines (as the result of a genetic cross) to identify general regions of interest, with the advantage of requiring few genetic markers to ensure genome wide coverage and high statistical power per allele. Linkage analysis, however, h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buckler Laboratory
A buckler (French ''bouclier'' 'shield', from Old French ''bocle, boucle'' ' boss') is a small shield, up to 45 cm (up to 18 in) in diameter, gripped in the fist with a central handle behind the boss. It became more common as a companion weapon in hand-to-hand combat during the Medieval and Renaissance periods. Its size made it poor protection against missile weapons (e.g., arrows) but useful in deflecting the blow of an opponent's weapons, binding their arms, hindering their movements, or punching them. The seminal study of the topic has been undertaken by Herbert Schmidt and has devised the following typology: * Type I: round * Type II: rectangular or trapezoidal * Type III: oval or teardrop shaped with the cross-section of the buckler further refining these types: * Type a: flat * Type b: concave * Type c: convex * Type d: wavy The combination of the two classifiers determines the buckler type. Thus a Type Ia buckler is a round flat buckler; a Type IId buckler is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
