Herpesvirales
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Herpesvirales
The ''Herpesvirales'' is an order of dsDNA viruses (Baltimore group I) with animal hosts, characterised by a common morphology consisting of an icosahedral capsid enclosed in a glycoprotein-containing lipid envelope. Common infections in humans caused by members of this order include cold sores, genital herpes, chickenpox, shingles, and glandular fever. ''Herpesvirales'' is the sole order in the class ''Herviviricetes'', which is the sole class in the phylum ''Peploviricota''. Virology Morphology All members of the order have a virion structure that consists of a DNA core surrounded by an icosahedral capsid composed of 12 pentavalent and 150 hexavalent capsomeres (T = 16). The capsid has a diameter of ~110 nanometers (nm) and is embedded in a proteinaceous matrix called the tegument, which in its turn is enclosed by a glycoprotein-containing lipid envelope with a diameter of about 200 nm. The DNA genome is linear and double stranded, with sizes in the range 125–290 kb ...
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Malacoherpesviridae
''Malacoherpesviridae'' is a family of DNA viruses in the order ''Herpesvirales''. Molluscs serve as natural hosts, making members of this family the only known herpesviruses to infect invertebrates. There are currently only two species recognised in this family, both classified into separate genera. Disease associated with this family includes sporadic episodes of high mortality among larvae and juveniles. The family name ''Malacoherpesviridae'' is derived from Greek language, Greek word 'μαλακός (malacos) meaning 'soft' and from Greek word 'μαλάκιον (malakion) meaning 'mollusc'. Taxonomy * ''Ostreavirus'' Davison et al., 2009 ** ''Ostreid herpesvirus 1'' Davison et al., 2009 – acronym: OsHV-1, common name: oyster herpesvirus, its host are bivalves (oysters) and the octopus species ''Octopus vulgaris''. * ''Aurivirus'' Savin et al., 2010, syn. ''Haliotivirus'' ** ''Haliotid herpesvirus 1'' Savin et al., 2010 – acronym: HaHV-1 or AbHV-1 (Corbeil et al., 2017, ...
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Salmonivirus
''Salmonivirus'' is a genus of viruses in the order ''Herpesvirales'', in the family '' Alloherpesviridae''. Salmonidae serve as natural hosts. There are three species in this genus. Diseases associated with this genus include: salHV-3: epizootic epitheliotropic disease. Species The genus consists of the following three species: * '' Salmonid herpesvirus 1'' * ''Salmonid herpesvirus 2'' * ''Salmonid herpesvirus 3 ''Salmonid herpesvirus 3'' (SalHV-3) is a species of virus in the genus ''Salmonivirus'', family ''Alloherpesviridae'', and order ''Herpesvirales The ''Herpesvirales'' is an order of dsDNA viruses (Baltimore group I) with animal hosts, charact ...'' Structure Viruses in ''Salmonivirus'' are enveloped, with icosahedral and spherical to pleomorphic geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented. Life cycle Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attach ...
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Mardivirus
''Mardivirus'' is a genus of viruses in the order ''Herpesvirales'', in the family ''Herpesviridae'', in the subfamily ''Alphaherpesvirinae''. Chickens, turkeys, and quail serve as natural hosts. There are six species in this genus. Diseases associated with this genus include: Marek's disease, which causes asymmetric paralysis of one or more limbs, neurological symptoms, and development of multiple lymphomas that manifest as solid tumors. ''Gallid herpesvirus 2'' (also known as Marek's disease virus) is the only one of these viruses known to be pathogenic and due to the antigenic similarity between the three viruses the other two have been used to vaccinate against Marek's disease. These viruses have double stranded DNA genomes with no RNA intermediate. Species The genus consists of the following six species: * ''Anatid alphaherpesvirus 1'' * ''Columbid alphaherpesvirus 1'' * ''Gallid alphaherpesvirus 2'' * ''Gallid alphaherpesvirus 3'' * ''Meleagrid alphaherpesvirus 1'' * ''S ...
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Herpesviridae
''Herpesviridae'' is a large family of DNA viruses that cause infections and certain diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word ''ἕρπειν'' ( 'to creep'), referring to spreading cutaneous lesions, usually involving blisters, seen in flares of herpes simplex 1, herpes simplex 2 and herpes zoster ( shingles). In 1971, the International Committee on the Taxonomy of Viruses (ICTV) established ''Herpesvirus'' as a genus with 23 viruses among four groups. As of 2020, 115 species are recognized, all but one of which are in one of the three subfamilies. Herpesviruses can cause both latent and lytic infections. Nine herpesvirus types are known to primarily infect humans, at least five of which – herpes simplex viruses 1 and 2 (HSV-1 and HSV-2, also known as HHV-1 and HHV-2; both of which can cause orolabial herpes and genital herpes), varicella zoster virus (or HHV-3; the cause ...
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Simplexvirus
''Simplexvirus'' is a genus of viruses in the order ''Herpesvirales'', in the family ''Herpesviridae'', in the subfamily ''Alphaherpesvirinae''. Humans and mammals serve as natural hosts. Diseases associated with this genus include skin vesicles or mucosal ulcers, rarely encephalitis, and meningitis. Species The following 15 species are assigned to the genus: * '' Ateline alphaherpesvirus 1'' * '' Bovine alphaherpesvirus 2'' * '' Cercopithecine alphaherpesvirus 2'' * ''Human alphaherpesvirus 1'' * '' Human alphaherpesvirus 2'' * '' Leporid alphaherpesvirus 4'' * ''Macacine alphaherpesvirus 1'' * '' Macacine alphaherpesvirus 2'' * '' Macacine alphaherpesvirus 3'' * ''Macropodid alphaherpesvirus 1'' * ''Macropodid alphaherpesvirus 2 ''Macropodid alphaherpesvirus 2'' (MaHV-2) is a species of herpesvirus in the genus ''Simplexvirus''. It was officially accepted as a valid species by the International Committee on Taxonomy of Viruses in 2004. Hosts ''Macropodid alphaherpe ... ...
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Human Alphaherpesvirus 1
''Human alphaherpesvirus 1'' (HHV-1) is a species of virus in the genus ''Simplexvirus'', subfamily ''Alphaherpesvirinae'', family ''Herpesviridae'', and order ''Herpesvirales''. Evolution The ''Human alphaherpesvirus 1'' virus can be classified into six clades. Four of these occur in East Africa, one in East Asia and one in Europe and North America. This suggests that the virus may have originated in East Africa. The most recent common ancestor of the Eurasian strains appears to have evolved ~60,000 years ago. Pathology ''Human alphaherpesvirus 1'' infects humans, most often as cold sores. It is very common and contagious; about 67% of the world population under the age of 50 has ''Human alphaherpesvirus 1''. It is often acquired orally during childhood. It may also be sexually transmitted, including contact with saliva, such as kissing and mouth-to-genital contact (oral sex). The virus tends to reside in the trigeminal ganglia. This species appears to be particularly dama ...
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Human Alphaherpesvirus 2
''Human alphaherpesvirus 2'' (HHV-2) is a species of virus in the genus ''Simplexvirus'', subfamily ''Alphaherpesvirinae'', family ''Herpesviridae'', and order ''Herpesvirales''. Evolution ''Human alphaherpesvirus 2'' can be divided into two clades: one is globally distributed and the other is mostly limited to sub Saharan Africa.Burrel S, Boutolleau D, Ryu D, Agut H, Merkel K, Leendertz FH, Calvignac-Spencer S (2017) Ancient recombination events between human herpes simplex viruses. Mol Biol Evol Pathology ''Human alphaherpesvirus 2'' infects humans, most often as genital herpes. In the United States more than one in six people have the virus. It is primarily a sexually transmitted infection. ''Human alphaherpesvirus 2'' tends to reside in the sacral ganglia. ''Human alphaherpesvirus 2'' is periodically shed in the human genital tract, most often asymptomatically. Most sexual transmissions occur during periods of asymptomatic shedding. Asymptomatic reactivation means that ...
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Alloherpesviridae
''Alloherpesviridae'' is a family of viruses in the order ''Herpesvirales''. This family includes the species that infect fish and amphibians. Phylogenetic studies have confirmed the validity of this family and suggest that it may be divided into two clades: one consisting of viruses from cyprinid and anguillid hosts and the other of viruses from ictalurid, salmonid, acipenserid, and ranid hosts. There are currently 13 species in this family, divided among four genera. A disease associated with this family includes channel catfish disease. Taxonomy ''Alloherpesviridae'' was established as a family in 2005. Genera The family contains the following four genera: * '' Batrachovirus'' * '' Cyprinivirus'' * '' Ictalurivirus'' * ''Salmonivirus ''Salmonivirus'' is a genus of viruses in the order ''Herpesvirales'', in the family '' Alloherpesviridae''. Salmonidae serve as natural hosts. There are three species in this genus. Diseases associated with this genus include: salHV-3: epiz ...
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Alphaherpesvirinae
''Alphaherpesvirinae'' is a subfamily of viruses in the family ''Herpesviridae'', primarily distinguished by reproducing more quickly than other subfamilies in the ''Herpesviridae''. In animal virology the most important herpesviruses belong to the Alphaherpesvirinae. Pseudorabies virus is the causative agent of Aujeszky's disease in pigs and ''Bovine herpesvirus 1'' is the causative agent of bovine infectious rhinotracheitis and pustular vulvovaginitis. Mammals serve as natural hosts. There are currently 45 species in this subfamily, divided among 5 genera with one species unassigned to a genus. Diseases associated with this subfamily include: HHV-1 and HHV-2: skin vesicles or mucosal ulcers, rarely encephalitis and meningitis, HHV-3: chickenpox (varicella) and shingles, GaHV-2: Marek's disease. Genera ''Alphaherpesvirinae'' consists of the following five genera: * ''Iltovirus'' * ''Mardivirus'' * ''Scutavirus'' * ''Simplexvirus'' * ''Varicellovirus'' The species ''Chelo ...
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Iltovirus
''Iltovirus'' is a genus of viruses in the order ''Herpesvirales'', in the family ''Herpesviridae'', in the subfamily ''Alphaherpesvirinae''. Birds, galliform birds, psittacine birds, chickens, turkeys, and quail Quail is a collective name for several genera of mid-sized birds generally placed in the order Galliformes. The collective noun for a group of quail is a flock, covey, or bevy. Old World quail are placed in the family Phasianidae, and New Wor ... serve as natural hosts. There are only two species in this genus. Diseases associated with this genus include: acute respiratory diseases: gaHV-1: infectious laryngotracheitis; psHV-1: Pacheco's disease. Species The genus consists of the following two species: * '' Gallid alphaherpesvirus 1'' * '' Psittacid alphaherpesvirus 1'' Structure Viruses in ''Iltovirus'' are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. The diameter is around 120-200 nm. Genomes are linea ...
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Ictalurivirus
''Ictalurivirus'' is a genus of viruses in the order ''Herpesvirales'', in the family ''Alloherpesviridae ''Alloherpesviridae'' is a family of viruses in the order ''Herpesvirales''. This family includes the species that infect fish and amphibians. Phylogenetic studies have confirmed the validity of this family and suggest that it may be divided in ...''. Fish serve as natural hosts. There are three species in this genus. Diseases associated with this genus include: channel catfish disease. Species The genus consists of the following three species: * '' Acipenserid herpesvirus 2'' * '' Ictalurid herpesvirus 1'' * '' Ictalurid herpesvirus 2'' Structure Viruses in ''Ictalurivirus'' are enveloped, with icosahedral and spherical to pleomorphic geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 134kb in length. Life cycle Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved ...
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Cyprinivirus
''Cyprinivirus'' is a genus of viruses in the order ''Herpesvirales'', in the family ''Alloherpesviridae''. Freshwater eels serve as natural hosts. There are four species in this genus. Diseases associated with this genus include: hemorrhagic disease. Species The genus consists of the following four species: * '' Anguillid herpesvirus 1'' * '' Cyprinid herpesvirus 1'' * '' Cyprinid herpesvirus 2'' * ''Cyprinid herpesvirus 3 ''Cyprinid herpesvirus 3'' (also CyHV-3, koi herpes virus or KHV) is a species of virus causing a viral disease that is very contagious to the common carp ''Cyprinus carpio''. Pathology It is most commonly found in ornamental koi, which are of ...'' Structure Viruses in ''Cyprinivirus'' are enveloped, with icosahedral and spherical to pleomorphic geometries, and T=16 symmetry. The diameter is around 200 nm. Genomes are linear and non-segmented, around 10kb in length. The genome codes for 136 proteins. Life cycle Viral replication is nuclea ...
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