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Harry Raymond Eastlack
Harry Raymond Eastlack, Jr. (17 November 1933 – 11 November 1973) was the subject of the most recognized case of FOP (fibrodysplasia ossificans progressiva) from the 20th century. His case is also particularly acknowledged, by scientists and researchers, for his contribution to medical advancement. After suffering from a rare, disabling, and currently incurable genetic disease, Eastlack decided to have his skeleton and medical history donated to the Mütter Museum of the College of Physicians of Philadelphia in support of FOP research. His skeleton is one of the few FOP-presenting, fully articulated ones in existence, and it has proved valuable to the study of the disease. As is characteristic of FOP patients, Eastlack did not demonstrate any possible sign of a disease at birth except for a malformation of the big toes. At the time it was not recognized as the first clinical sign of FOP. It was not until 1937 when the first heterotopic ossification symptom surfaced. By the time ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mütter Museum
The Mütter Museum is a medical museum located in the Center City area of Philadelphia, Pennsylvania. It contains a collection of anatomical and pathological specimens, wax models, and antique medical equipment. The museum is part of The College of Physicians of Philadelphia. The original purpose of the collection, donated by Dr. Thomas Dent Mütter in 1858, was for biomedical research and education. Collections The Mütter Museum originated as a collection of specimens and medical tools used for education in medicine. The museum has a collection of over 20,000 specimens, of which about 10% were on display as of 2018. This does not include the large literary collection contained within the Historical Medical Library, which is also housed within the College of Physicians of Philadelphia. Osteological (skeletal) specimens The Mütter Museum is home to over 3,000 osteological specimens, including several full skeletons. One of the most famous of these is the fully articulat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ACVR1
Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ''ACVR1'' gene; also known as ALK-2 (activin receptor-like kinase-2). ACVR1 has been linked to the 2q23-24 region of the genome. This protein is important in the bone morphogenic protein (BMP) pathway which is responsible for the development and repair of the skeletal system. While knock-out models with this gene are in progress, the ACVR1 gene has been connected to fibrodysplasia ossificans progressiva, a disease characterized by the formation of heterotopic bone throughout the body. It is a bone morphogenetic protein receptor, type 1. Function Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
People From Philadelphia
A person ( : people) is a being that has certain capacities or attributes such as reason, morality, consciousness or self-consciousness, and being a part of a culturally established form of social relations such as kinship, ownership of property, or legal responsibility. The defining features of personhood and, consequently, what makes a person count as a person, differ widely among cultures and contexts. In addition to the question of personhood, of what makes a being count as a person to begin with, there are further questions about personal identity and self: both about what makes any particular person that particular person instead of another, and about what makes a person at one time the same person as they were or will be at another time despite any intervening changes. The plural form "people" is often used to refer to an entire nation or ethnic group (as in "a people"), and this was the original meaning of the word; it subsequently acquired its use as a plural form of per ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1973 Deaths
Events January * January 1 - The United Kingdom, the Republic of Ireland and Denmark enter the European Economic Community, which later becomes the European Union. * January 15 – Vietnam War: Citing progress in peace negotiations, U.S. President Richard Nixon announces the suspension of offensive action in North Vietnam. * January 17 – Ferdinand Marcos becomes President for Life of the Philippines. * January 20 – Richard Nixon is sworn in for a second term as President of the United States. Nixon is the only person to have been sworn in twice as President ( 1969, 1973) and Vice President of the United States ( 1953, 1957). * January 22 ** George Foreman defeats Joe Frazier to win the heavyweight world boxing championship. ** A Royal Jordanian Boeing 707 flight from Jeddah crashes in Kano, Nigeria; 176 people are killed. * January 27 – U.S. involvement in the Vietnam War ends with the signing of the Paris Peace Accords. February * February 8 – A militar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1933 Births
Events January * January 11 – Sir Charles Kingsford Smith makes the first commercial flight between Australia and New Zealand. * January 17 – The United States Congress votes in favour of Philippines independence, against the wishes of U.S. President Herbert Hoover. * January 28 – "Pakistan Declaration": Choudhry Rahmat Ali publishes (in Cambridge, UK) a pamphlet entitled ''Now or Never; Are We to Live or Perish Forever?'', in which he calls for the creation of a Muslim state in northwest India that he calls " Pakstan"; this influences the Pakistan Movement. * January 30 ** National Socialist German Workers Party leader Adolf Hitler is appointed Chancellor of Germany by President of Germany Paul von Hindenburg. ** Édouard Daladier forms a government in France in succession to Joseph Paul-Boncour. He is succeeded on October 26 by Albert Sarraut and on November 26 by Camille Chautemps. February * February 1 – Adolf Hitler gives his "Proclamation to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tell-Tale (film)
''Tell-Tale'' is a 2009 science fiction horror film inspired by Edgar Allan Poe's 1843 short story "The Tell-Tale Heart". It is directed by Michael Cuesta and stars Josh Lucas, Lena Headey, and Brian Cox and is produced by Tony Scott Anthony David Leighton Scott (21 June 1944 – 19 August 2012) was an English film director and producer. He was known for directing highly successful action and thriller films such as '' Top Gun'' (1986), '' Beverly Hills Cop II'' (1987), ''D ... and Ridley Scott. A man's recently transplanted heart leads him on a frantic search to find the donor's killer before a similar fate befalls him. Plot In Providence, a husband and his wife die in a botched robbery; we see flickers of his last memories. His heart goes to Terry Bernard, a single father raising a girl with a rare degenerative disease. After the operation, Terry has flashes of memory from the last moments of the dead donor's life. Then, he recognizes one of the donor's killers and follo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Tell-Tale Heart
"The Tell-Tale Heart" is a short story by American writer Edgar Allan Poe, first published in 1843. It is related by an unnamed narrator who endeavors to convince the reader of the narrator's sanity while simultaneously describing a murder the narrator committed. The victim was an old man with a filmy pale blue "vulture-eye", as the narrator calls it. The narrator emphasizes the careful calculation of the murder, attempting the perfect crime, complete with dismembering the body in the bathtub and hiding it under the floorboards. Ultimately, the narrator's actions result in hearing a thumping sound, which the narrator interprets as the dead man's beating heart. The story was first published in James Russell Lowell's ''The Pioneer'' in January 1843. "The Tell-Tale Heart" is often considered a classic of the Gothic fiction genre and is one of Poe's best known short stories. The specific motivation for murder (aside from the narrator's hatred of the old man's eye), the relationship ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edgar Allan Poe
Edgar Allan Poe (; Edgar Poe; January 19, 1809 – October 7, 1849) was an American writer, poet, editor, and literary critic. Poe is best known for his poetry and short stories, particularly his tales of mystery and the macabre. He is widely regarded as a central figure of Romanticism in the United States, and of American literature. Poe was one of the country's earliest practitioners of the short story, and considered to be the inventor of the detective fiction genre, as well as a significant contributor to the emerging genre of science fiction. Poe is the first well-known American writer to earn a living through writing alone, resulting in a financially difficult life and career. Poe was born in Boston, the second child of actors David and Elizabeth "Eliza" Poe. His father abandoned the family in 1810, and when his mother died the following year, Poe was taken in by John and Frances Allan of Richmond, Virginia. They never formally adopted him, but he was with them well ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carol Orzel
Carol Orzel (April 20, 1959 – February 2018) was an American woman with fibrodysplasia ossificans progressiva (FOP). She advocated for research into FOP and was an activist for disability rights. Before her death, she requested that her skeleton be displayed in the Mütter Museum. Early life Orzel was born in Philadelphia in 1959 and diagnosed with FOP, a rare disease that causes tissue to ossify. In 1982 at age 23, she moved to Inglis House, a nursing-care facility, at its Belmont Avenue campus. Advocacy and association with University of Pennsylvania After moving to Inglis House, Orzel became a patient of doctor Frederick Kaplan at the University of Pennsylvania. Kaplan had never before met someone with FOP, and the disease would become his focus. Orzel gave annual talks to incoming medical students at University of Pennsylvania to help them better understand treating people with disabilities. The Mütter Museum notes that she "advocated for more research, established netw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International FOP Association
The International Fibrodysplasia Ossificans Progressiva Association (IFOPA) is a US-based 501(c)(3) non-profit organization supporting medical research, education and communication for those afflicted by the rare genetic condition Fibrodysplasia Ossificans Progressiva (FOP). IFOPA's mission is to fund research to find a cure for FOP while supporting, connecting, and advocating for individuals with FOP and their families, and raising awareness worldwide. IFOPA is governed by a volunteer board of directors which may range in number from 9 to 15, at least one of whom must have FOP. The association's location is 1520 Clay St., Suite H2, North Kansas City, MO, 64116, part of the Kansas City, Missouri metropolitan area. Founding and history IFOPA was founded in 1988 by Jeannie L. Peeper. Diagnosed with FOP in 1962 at age four, Peeper graduated from college in 1985 with a bachelor of arts degree in social work. Michael Zasloff, then at the National Institutes of Health (NIH), was stu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frederick Kaplan
Frederick S. Kaplan is an American medical doctor specializing in research of musculoskeletal disorders such as fibrodysplasia ossificans progressiva (FOP). Education Frederick Kaplan received a bachelor's degree from Johns Hopkins University in 1972. He also obtained his Doctor of Medicine (MD) from Johns Hopkins University, graduating in 1976. FOP research In the mid 1980s, Kaplan met David Romanoff, the medical director of the Inglis House—a residential care facility for adults with disabilities. Two residents of the facility were diagnosed with fibrodysplasia ossificans progressiva (FOP), a very rare medical condition in which the soft tissue of the body ossifies, or turns to bone, over time. Romanoff was "grappling" with caring for the patients, and asked Kaplan if he would like to meet them, which he did. This was his first encounter with the disease beyond reading about it. In 1988, Kaplan met immunologist and geneticist Michael Zasloff; Zasloff introduced him to a p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
College Of Physicians Of Philadelphia
The College of Physicians of Philadelphia is the oldest private medical society in the United States. Founded in 1787 by 24 Philadelphia physicians "to advance the Science of Medicine, and thereby lessen human misery, by investigating the diseases and remedies which are peculiar to our country" and to promote "order and uniformity in the practice of Physick," it has made important contributions to medical education and research. The College hosts the Mütter Museum, a gallery of 19th-century specimens, teaching models, instruments, and photographs, as well as the Historical Medical Library, which is one of the country's oldest medical libraries. The College of Physicians of Philadelphia Building, designed by the firm of Cope & Stewardson and built in 1909, was designated a U.S. National Historic Landmark in October, 2008. It was also then listed on the National Register of Historic Places. Current programs The College remains a private membership organization of physicians, whose ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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