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Human Coronavirus OC43
Human coronavirus OC43 (HCoV-OC43) is a member of the species ''Betacoronavirus 1, Betacoronavirus gravedinis'', which infects humans and cattle. The infecting coronavirus is an Viral envelope, enveloped, Sense (molecular biology), positive-sense, RNA, single-stranded RNA virus that enters its host cell by binding to the N-Acetylneuraminic acid, N-acetyl-9-O-acetylneuraminic acid receptor. OC43 is one of Coronavirus#Infection in humans, seven coronaviruses known to infect humans. It is one of the viruses responsible for the common cold and may have been responsible for the 1889–1890 pandemic. It has, like other coronaviruses from genus ''Betacoronavirus,'' subgenus ''Embecovirus'', an additional shorter spike protein called hemagglutinin esterase, hemagglutinin-esterase (HE). ]. Genetic and antigenic analyses reveal significant similarities between HCoV-OC43 and bovine coronavirus (BCoV), suggesting a zoonotic transmission event from cattle to humans. Molecular analysis estimate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transmission Electron Micrograph
Transmission electron microscopy (TEM) is a microscopy technique in which a beam of electrons is transmitted through a specimen to form an image. The specimen is most often an ultrathin section less than 100 nm thick or a suspension on a grid. An image is formed from the interaction of the electrons with the sample as the beam is transmitted through the specimen. The image is then magnified and Focus (optics), focused onto an imaging device, such as a fluorescent screen, a layer of photographic film, or a Detectors for transmission electron microscopy, detector such as a scintillator attached to a charge-coupled device or a direct electron detector. Transmission electron microscopes are capable of imaging at a significantly higher Optical resolution, resolution than Optical microscope, light microscopes, owing to the smaller de Broglie wavelength of electrons. This enables the instrument to capture fine detail—even as small as a single column of atoms, which is thousands o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Variant (biology)
In microbiology and virology, the term variant or genetic variant is used to describe a subtype of a microorganism that is genetically distinct from a main strain, but not sufficiently different to be termed a distinct strain. A similar distinction is made in botany between different cultivated varieties of a species of plant, termed cultivars. Viruses SARS-CoV-2 It was said in 2013 that "there is no universally accepted definition for the terms 'strain', 'variant', and 'isolate' in the virology community, and most virologists simply copy the usage of terms from others". The lack of precise definition continued in 2020; in the context of the Variant of Concern 202012/01 version of the SARS-CoV-2 virus, the website of the US Centers for Disease Control and Prevention The Centers for Disease Control and Prevention (CDC) is the National public health institutes, national public health agency of the United States. It is a Federal agencies of the United States, United St ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lower Respiratory Tract Infection
Lower respiratory tract infection (LRTI) is a term often used as a synonym for pneumonia but can also be applied to other types of infection including lung abscess and acute bronchitis. Symptoms include shortness of breath, weakness, fever, coughing and fatigue. A routine chest X-ray is not always necessary for people who have symptoms of a lower respiratory tract infection. Influenza affects both the upper and lower respiratory tracts. Antibiotics are the first line treatment for pneumonia; however, they are neither effective nor indicated for parasitic or viral infections. Acute bronchitis typically resolves on its own with time. In 2015 there were about 291 million cases. These resulted in 2.74 million deaths down from 3.4 million deaths in 1990. This was 4.8% of all deaths in 2013. The World Health Organization has reported that, in 2021, "Lower respiratory infections remained the world’s most deadly communicable disease other than COVID-19, ranked as the fifth lea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alphacoronavirus
Alphacoronaviruses (Alpha-CoV) are members of the first of the four genera (''Alpha''-, '' Beta-'', '' Gamma-'', and '' Delta-'') of coronaviruses. They are positive-sense, single-stranded RNA viruses that infect mammals, including humans. They have spherical virions with club-shaped surface projections formed by trimers of the spike protein, and a viral envelope. Alphacoronaviruses are in the subfamily ''Orthocoronavirinae'' of the family '' Coronaviridae''. Both the ''Alpha''- and ''Betacoronavirus'' lineages descend from the bat viral gene pool. Alphacoronaviruses were previously known as " phylogroup 1 coronaviruses". The Alphacoronavirus genus is very diverse, particularly in bats. Most bat originating strains haven't been successfully isolated and cultured in laboratory. Alphacoronaviruses infecting other mammal species have been much better studied, see List of Coronavirus live isolates. Etymology The name alphacoronavirus is derived from Ancient Greek ἄλφα ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Coronavirus 229E
Human coronavirus 229E (HCoV-229E, ''Alphacoronavirus chicagoense'') is a species of coronavirus which infects humans and bats. It is an Viral envelope, enveloped, Sense (molecular biology), positive-sense, RNA, single-stranded RNA virus which enters its host cell by binding to the Alanine aminopeptidase, APN receptor. Along with Human coronavirus OC43 (a member of the ''Betacoronavirus'' genus), it is one of the viruses responsible for the common cold. HCoV-229E is a member of the genus ''Alphacoronavirus'' and subgenus ''Duvinacovirus''. Transmission HCoV-229E transmits via droplet-respiration and fomites. Signs and symptoms HCoV-229E is associated with a range of respiratory symptoms, ranging from the common cold to high-morbidity outcomes such as pneumonia and bronchiolitis. However, such high Disease#Morbidity, morbidity outcomes are almost always seen in cases with co-infection with other respiratory pathogens; there is a single published case report to date of a 229E infe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Severe Acute Respiratory Syndrome Coronavirus 2
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19, the respiratory illness responsible for the COVID-19 pandemic. The virus previously had the Novel coronavirus, provisional name 2019 novel coronavirus (2019-nCoV), and has also been called human coronavirus 2019 (HCoV-19 or hCoV-19). First identified in the city of Wuhan, Hubei, China, the World Health Organization designated the outbreak a public health emergency of international concern from January 30, 2020, to May 5, 2023. SARS‑CoV‑2 is a positive-sense single-stranded RNA virus that is Contagious disease, contagious in humans. SARS‑CoV‑2 is a strain of the species ''Betacoronavirus pandemicum'' (SARSr-CoV), as is SARS-CoV-1, the virus that caused the 2002–2004 SARS outbreak. There are animal-borne coronavirus strains more closely related to SARS-CoV-2, the most closely known relative being the BANAL-52 bat coronavirus. SARS-CoV-2 is of Zoonosis, z ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COVID-19
Coronavirus disease 2019 (COVID-19) is a contagious disease caused by the coronavirus SARS-CoV-2. In January 2020, the disease spread worldwide, resulting in the COVID-19 pandemic. The symptoms of COVID‑19 can vary but often include fever, fatigue, cough, breathing difficulties, anosmia, loss of smell, and ageusia, loss of taste. Symptoms may begin one to fourteen days incubation period, after exposure to the virus. At least a third of people who are infected asymptomatic, do not develop noticeable symptoms. Of those who develop symptoms noticeable enough to be classified as patients, most (81%) develop mild to moderate symptoms (up to mild pneumonia), while 14% develop severe symptoms (dyspnea, hypoxia (medical), hypoxia, or more than 50% lung involvement on imaging), and 5% develop critical symptoms (respiratory failure, shock (circulatory), shock, or organ dysfunction, multiorgan dysfunction). Older people have a higher risk of developing severe symptoms. Some complicati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COVID-19 Pandemic
The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began with an disease outbreak, outbreak of COVID-19 in Wuhan, China, in December 2019. Soon after, it spread to other areas of Asia, and COVID-19 pandemic by country and territory, then worldwide in early 2020. The World Health Organization (WHO) declared the outbreak a public health emergency of international concern (PHEIC) on 30 January 2020, and assessed the outbreak as having become a pandemic on 11 March. COVID-19 symptoms range from asymptomatic to deadly, but most commonly include fever, sore throat, nocturnal cough, and fatigue. Transmission of COVID-19, Transmission of the virus is often airborne transmission, through airborne particles. Mutations have variants of SARS-CoV-2, produced many strains (variants) with varying degrees of infectivity and virulence. COVID-19 vaccines were developed rapidly and deplo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Influenza
Influenza, commonly known as the flu, is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin one to four (typically two) days after exposure to the virus and last for about two to eight days. Diarrhea and vomiting can occur, particularly in children. Influenza may progress to pneumonia from the virus or a subsequent bacterial infection. Other complications include acute respiratory distress syndrome, meningitis, encephalitis, and worsening of pre-existing health problems such as asthma and cardiovascular disease. There are four types of influenza virus: types A, B, C, and D. Aquatic birds are the primary source of influenza A virus (IAV), which is also widespread in various mammals, including humans and pigs. Influenza B virus (IBV) and influenza C virus (ICV) primarily infect humans, and influenza D virus (IDV) i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spillover Infection
Spillover infection, also known as pathogen spillover and spillover event, occurs when a reservoir population with a high pathogen prevalence comes into contact with a novel host population. The pathogen is transmitted from the reservoir population and may or may not be transmitted within the host population. Due to climate change and land use expansion, the risk of viral spillover is predicted to significantly increase. Spillover zoonoses Spillover is a common event; in fact, more than two-thirds of human viruses are zoonotic. Most spillover events result in self-limited cases with no further human-to-human transmission, as occurs, for example, with rabies, anthrax, histoplasmosis or hydatidosis. Other zoonotic pathogens are able to be transmitted by humans to produce secondary cases and even to establish limited chains of transmission. Some examples are the Ebola and Marburg filoviruses, the MERS and SARS coronaviruses and some avian flu viruses. Finally, some spillover eve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bovine Coronavirus
Bovine coronavirus (BCV or BCoV) is a coronavirus which is a member of the species '' Betacoronavirus gravedinis''. The infecting virus is an enveloped, positive-sense, single-stranded RNA virus which enters its host cell by binding to the N-acetyl-9-O-acetylneuraminic acid receptor. Infection causes calf enteritis and contributes to the enzootic pneumonia complex in calves. It can also cause winter dysentery in adult cattle. It can infect both domestic and wild ruminants and has a worldwide distribution. Transmission is horizontal, via oro-fecal or respiratory routes. Like other coronaviruses from genus '' Betacoronavirus,'' subgenus '' Embecovirus'', it has a surface protein called hemagglutinin esterase (HE) in addition to the four structural proteins shared by all coronaviruses ( spike, membrane, nucleocapsid, and envelope proteins). Virology BCoV has 95% similarity with human coronavirus OC43 and 93% to porcine hemagglutinating encephalomyelitis virus. According to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Most Recent Common Ancestor
A most recent common ancestor (MRCA), also known as a last common ancestor (LCA), is the most recent individual from which all organisms of a set are inferred to have descended. The most recent common ancestor of a higher taxon is generally assumed to have been a species. The term is also used in reference to the ancestry of groups of genes (haplotypes) rather than organisms. The ancestry of a set of individuals can sometimes be determined by referring to an established pedigree, although this may refer only to patrilineal or matrilineal lines for sexually-reproducing organisms with two parents, four grandparents, etc. However, in general, it is impossible to identify the exact MRCA of a large set of individuals, but an estimate of the time at which the MRCA lived can often be given. Such ''time to most recent common ancestor'' (''TMRCA'') estimates can be given based on DNA test results and established mutation rates as practiced in genetic genealogy, or by reference to a non- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
