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Gintonin
Gintonin is a glycolipoprotein fraction isolated from ginseng. The non-saponin ingredient was designated as gintonin, where ''gin'' was derived from ginseng, ''ton'' from the tonic effects of ginseng, and ''in'' from protein. The main component of gintonin is a complex of lysophosphatidic acids (LPA) and ginseng proteins such as ginseng major latex-like protein151 (GLP151) and ginseng ribonuclease-like storage protein. GLP151 is a first plant-derived LPA binding protein as one of Bet v 1 superfamily. GLP151 has a LPA binding domain on H147 and H148 at C-terminal. These two histidine residues bind to phosphate group of LPA and deliver LPA to its cognate receptors to elicit cellular effects such as a2+ transient and morphological changes. Lysophospholipid receptors are the high affinity and selective target receptor of gintonin. Gintonin induces a2+ transient in animal cells. Gintonin also shows ''in vivo'' anti-Alzheimer's disease effects through LPA receptor-mediated non-amylo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gintonin Structure
Gintonin is a glycolipoprotein Fraction (chemistry), fraction isolated from ginseng. The non-saponin ingredient was designated as gintonin, where ''gin'' was derived from ginseng, ''ton'' from the tonic effects of ginseng, and ''in'' from protein. The main component of gintonin is a complex of lysophosphatidic acids (LPA) and ginseng proteins such as ginseng major latex-like protein151 (GLP151) and ginseng ribonuclease-like storage protein. GLP151 is a first plant-derived LPA binding protein as one of Bet v 1 superfamily. GLP151 has a LPA binding domain on H147 and H148 at C-terminal. These two histidine residues bind to phosphate group of LPA and deliver LPA to its cognate receptors to elicit cellular effects such as [Ca2+]i transient and morphological changes. Lysophospholipid receptors are the high affinity and selective target receptor of gintonin. Gintonin induces [Ca2+]i transient in animal cells. Gintonin also shows ''in vivo'' anti-Alzheimer's disease effects through LPA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lysophosphatidic Acid
Lysophosphatidic acid (LPA) is a phospholipid derivative that can act as a signaling molecule. Function LPA acts as a potent mitogen due to its activation of three high-affinity G-protein-coupled receptors called LPAR1, LPAR2, and LPAR3 (also known as EDG2, EDG4, and EDG7). Additional, newly identified LPA receptors include LPAR4 (P2RY9, GPR23), LPAR5 (GPR92) and LPAR6 (P2RY5, GPR87). Clinical significance Because of its ability to stimulate cell proliferation, aberrant LPA-signaling has been linked to cancer in numerous ways. Dysregulation of autotaxin or the LPA receptors can lead to hyperproliferation, which may contribute to oncogenesis and metastasis. LPA may be the cause of pruritus (itching) in individuals with cholestatic (impaired bile flow) diseases. GTPase activation Downstream of LPA receptor activation, the small GTPase Rho can be activated, subsequently activating Rho kinase. This can lead to the formation of stress fibers and cell migration through the inhibiti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lysophospholipid Receptor
The lysophospholipid receptor (LPL-R) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors Receptor may refer to: *Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a n ..., each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg" (an acronym for endothelial differentiation gene). Ligands The ligands for LPL-R group are the lysophospholipid extracellular lipid signaling, signaling molecules, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Origin of name The term ''lysophospholipid'' (LPL) refers to any phospholipid that is missing one of its two O-fatty acid, acyl chains. Thus, LPLs have a free alcohol in either the sn-1 or the sn-2 pos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ginsenoside
Ginsenosides or panaxosides are a class of natural product steroid glycosides and triterpene saponins. Compounds in this family are found almost exclusively in the plant genus ''Panax'' (ginseng), which has a long history of use in traditional medicine that has led to the study of pharmacological effects of ginseng compounds. As a class, ginsenosides exhibit a large variety of subtle and difficult-to-characterize biological effects when studied in isolation. Ginsenosides can be isolated from various parts of the plant, though typically from the roots, and can be purified by column chromatography. The chemical profiles of ''Panax'' species are distinct; although Asian ginseng, ''Panax ginseng'', has been most widely studied due to its use in traditional Chinese medicine, there are ginsenosides unique to American ginseng (''Panax quinquefolius'') and Japanese ginseng (''Panax japonicus''). Ginsenoside content also varies significantly due to environmental effects. Classification G ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lysophosphatidic Acid
Lysophosphatidic acid (LPA) is a phospholipid derivative that can act as a signaling molecule. Function LPA acts as a potent mitogen due to its activation of three high-affinity G-protein-coupled receptors called LPAR1, LPAR2, and LPAR3 (also known as EDG2, EDG4, and EDG7). Additional, newly identified LPA receptors include LPAR4 (P2RY9, GPR23), LPAR5 (GPR92) and LPAR6 (P2RY5, GPR87). Clinical significance Because of its ability to stimulate cell proliferation, aberrant LPA-signaling has been linked to cancer in numerous ways. Dysregulation of autotaxin or the LPA receptors can lead to hyperproliferation, which may contribute to oncogenesis and metastasis. LPA may be the cause of pruritus (itching) in individuals with cholestatic (impaired bile flow) diseases. GTPase activation Downstream of LPA receptor activation, the small GTPase Rho can be activated, subsequently activating Rho kinase. This can lead to the formation of stress fibers and cell migration through the inhibiti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ginseng
Ginseng () is the root of plants in the genus ''Panax'', such as Korean ginseng ('' P. ginseng''), South China ginseng ('' P. notoginseng''), and American ginseng ('' P. quinquefolius''), typically characterized by the presence of ginsenosides and gintonin. Ginseng is most commonly used in the cuisines and medicines of China and Korea. Although ginseng has been used in traditional medicine over centuries, modern clinical research is inconclusive about its medical effectiveness. There is no substantial evidence that ginseng is effective for treating any medical condition, and in the United States, for example, its use has not been approved by the US Food and Drug Administration (FDA) as a prescription drug. Although ginseng is commonly sold as a dietary supplement, inconsistent manufacturing practices for supplements have led to analyses showing that ginseng products may be contaminated with toxic metals or unrelated filler compounds, and its excessive use may have adverse effec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fraction (chemistry)
A fraction in chemistry is a quantity collected from a batch of a substance in a fractionating separation process. In such a process, a mixture is separated into fractions, which have compositions that vary according to a gradient. A fraction can be defined as a group of chemicals that have similar boiling points. A common fractionating process is fractional distillation. It is used to produce liquor and various hydrocarbon fuels, such as gasoline, kerosene and diesel. A fraction is the product of a fractionating column, a vast chamber designed to separate different substances (such as crude oil) based on their boiling point. Fraction could also refer to a description of the composition of a mixture, e.g. mass fraction or mole fraction In chemistry, the mole fraction or molar fraction (''xi'' or ) is defined as unit of the amount of a constituent (expressed in moles), ''ni'', divided by the total amount of all constituents in a mixture (also expressed in moles), ''n''tot. This ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saponin
Saponins (Latin "sapon", soap + "-in", one of), also selectively referred to as triterpene glycosides, are bitter-tasting usually toxic plant-derived organic chemicals that have a foamy quality when agitated in water. They are widely distributed but found particularly in soapwort (genus Saponaria), a flowering plant, the soapbark tree (''Quillaja saponaria'') and soybeans (''Glycine max'' L.). They are used in soaps, medicinals, fire extinguishers, speciously as dietary supplements, for synthesis of steroids, and in carbonated beverages (the head on a mug of root beer). Structurally, they are glycosides, sugars bonded to another organic molecule, usually a steroid or triterpene, a steroid building block. Saponins are both water and fat soluble, which gives them their useful soap properties. Some examples of these chemicals are glycyrrhizin, licorice flavoring; and quillaia (alt. quillaja), a bark extract used in beverages. Uses The saponins are a subclass of terpenoids, the larges ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autotaxin
Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2), is an enzyme that in humans is encoded by the ''ENPP2'' gene. Function Autotaxin (ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2 or ENPP2) is a secreted enzyme important for generating the lipid signaling molecule lysophosphatidic acid (LPA). Autotaxin has lyso phospholipase D activity that converts lysophosphatidylcholine into LPA. Autotaxin was originally identified as a tumor cell-motility-stimulating factor; later it was shown to be LPA (which signals through lysophospholipid receptors), the lipid product of the reaction catalyzed by autotaxin, which is responsible for its effects on cell-proliferation. The protein encoded by this gene functions as a phosphodiesterase. Autotaxin is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants have been identified. Autotaxin is able to cleave the phosphodie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ginseng
Ginseng () is the root of plants in the genus ''Panax'', such as Korean ginseng ('' P. ginseng''), South China ginseng ('' P. notoginseng''), and American ginseng ('' P. quinquefolius''), typically characterized by the presence of ginsenosides and gintonin. Ginseng is most commonly used in the cuisines and medicines of China and Korea. Although ginseng has been used in traditional medicine over centuries, modern clinical research is inconclusive about its medical effectiveness. There is no substantial evidence that ginseng is effective for treating any medical condition, and in the United States, for example, its use has not been approved by the US Food and Drug Administration (FDA) as a prescription drug. Although ginseng is commonly sold as a dietary supplement, inconsistent manufacturing practices for supplements have led to analyses showing that ginseng products may be contaminated with toxic metals or unrelated filler compounds, and its excessive use may have adverse effec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
