|
Fomepizole
Fomepizole, also known as 4-methylpyrazole, is a medication used to treat methanol poisoning, methanol and ethylene glycol poisoning. It may be used alone or together with hemodialysis. It is given by intravenous, injection into a vein. Common side effects include headache, nausea, sleepiness, and unsteadiness. It is unclear if use during pregnancy is safe for the baby. Fomepizole works by blocking the enzyme that converts methanol and ethylene glycol to their toxic breakdown products. Fomepizole was approved for medical use in the United States in 1997. It is on the WHO Model List of Essential Medicines, World Health Organization's List of Essential Medicines. Medical use Fomepizole is used to treat ethylene glycol and methanol poisoning. It acts to inhibit the breakdown of these toxins into their active toxic metabolites. Fomepizole is a competitive inhibition, competitive inhibitor of the enzyme alcohol dehydrogenase, found in the liver. This enzyme plays a key role in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethylene Glycol Poisoning
Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol. Early symptoms include Substance intoxication, intoxication, vomiting and abdominal pain. Later symptoms may include a decreased level of consciousness, headache, and seizures. Long term outcomes may include kidney failure and brain damage. Toxicity and death may occur after drinking even in a small amount as ethylene glycol is more toxic than other Diol, diols. Ethylene glycol is a colorless, odorless, sweet liquid, commonly found in antifreeze. It may be drunk accidentally or intentionally in a suicide attempt. When broken down by the body it results in glycolic acid and oxalic acid which cause most of the toxicity. The diagnosis may be suspected when calcium oxalate crystals are seen in the urine or when acidosis or an increased osmol gap is present in the blood. Diagnosis may be confirmed by measuring ethylene glycol levels in the blood; however, many hospitals do not have the ability to perform this ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |