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Foekje Dillema
Foekje Dillema (18 September 1926 – 5 December 2007) was a Dutch track and field athlete. Biography Dillema was named "athlete of the match" in 1949 after winning the 100 metres and 200 metres race during a tournament in London. She was an important rival for another Dutch athlete Fanny Blankers-Koen, who won four gold medals during the 1948 Summer Olympics and who was voted "Female Athlete of the Century" by the International Association of Athletics Federations (IAAF) in 1999. In 1950 Dillema was banned from competition for life by the IAAF. Dillema had refused to go to a mandatory sex test for the European championships in Brussels in August 1950. Dillema was the first subject of a mandatory gender verification. The IAAF introduced mandatory sex verification in 1950 and continued this practice until 1992. Dillema's national record of 24.1 seconds for the 200 metres was erased. On 13 July 1950, Dillema was stopped on her way to an international meeting in France by the Dut ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Burum, Netherlands
Burum (West Frisian language: ''Boerum'') is a village in Noardeast-Fryslân municipality, Friesland in the Netherlands. It is the site of a ground station of the Dutch Nationale SIGINT Organisatie (national signals intelligence service), which intercepts satellite communications.Nationale SIGINT Organisatie " Archive . Retrieved on 13 June 2013. Burum also provides reference signals for Enha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Y-chromosome
The Y chromosome is one of two sex chromosomes (allosomes) in therian mammals, including humans, and many other animals. The other is the X chromosome. Y is normally the sex-determining chromosome in many species, since it is the presence or absence of Y that determines the male or female sex of offspring produced in sexual reproduction. In mammals, the Y chromosome contains the gene SRY, which triggers male development. The DNA in the human Y chromosome is composed of about 59 million base pairs, making it similar in size to chromosome 19. The Y chromosome is passed only from father to son. With a 30% difference between humans and chimpanzees, the Y chromosome is one of the fastest-evolving parts of the human genome. The human Y chromosome carries an estimated 100–200 genes, with between 45 and 73 of these being protein-coding. All single-copy Y-linked genes are hemizygous (present on only one chromosome) except in cases of aneuploidy such as XYY syndrome or XXYY syndrome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gender Verification In Sports
Sex verification in sports (also known as gender verification, or loosely as gender determination or a sex test) occurs because eligibility of athletes to compete is restricted whenever sporting events are limited to a single sex, which is generally the case, as well as when events are limited to mixed-sex teams of defined composition (e.g., most ''pairs'' events). Practice has varied tremendously over time, across borders and by competitive level. Issues have arisen multiple times in the Olympic games and other high-profile sporting competitions, for example allegations that certain male athletes attempted to compete as women or that certain female athletes had intersex conditions perceived to give unfair advantage. Sex verification is not typically conducted on athletes competing in the male category. The first mandatory sex test issued by the International Association of Athletics Federations (IAAF), the world's track and field governing body, for woman athletes was in July 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intersex
Intersex people are individuals born with any of several sex characteristics including chromosome patterns, gonads, or genitals that, according to the Office of the United Nations High Commissioner for Human Rights, "do not fit typical binary notions of male or female bodies". Sex assignment at birth usually aligns with a child's anatomical sex and phenotype. The number of births with ambiguous genitals is in the range of 1:2000–1:4500 (0.022%–0.05%). Other conditions involve atypical chromosomes, gonads, or hormones. Some persons may be assigned and raised as a girl or boy but then identify with another gender later in life, while most continue to identify with their assigned sex. The number of births where the baby is intersex has been reported differently depending on who reports and which definition of intersex is used. Anne Fausto-Sterling and her co-authors suggest that the prevalence of "nondimorphic sexual development" might be as high as 1.7%. A study publis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Complete Androgen Insensitivity Syndrome
Complete androgen insensitivity syndrome (CAIS) is an AIS condition that results in the complete inability of the cell to respond to androgens. As such, the insensitivity to androgens is only clinically significant when it occurs in individuals who are exposed to significant amounts of testosterone at some point in their lives. The unresponsiveness of the cell to the presence of androgenic hormones prevents the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does allow, without significant impairment, female genital and sexual development in those with the condition. All human fetuses begin fetal development looking similar, with both the Müllerian duct system (female) and the Wolffian duct system (male) developing. It is at the seventh week of gestation that the bodies of unaffected individuals with the XY karyotype begin their masculinization: i.e., the Wolffian duct system is pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Testosterone (medication)
Testosterone (T) is a medication and naturally occurring steroid hormone. It is used to treat male hypogonadism, gender dysphoria, and certain types of breast cancer. It may also be used to increase athletic ability in the form of doping. It is unclear if the use of testosterone for low levels due to aging is beneficial or harmful. Testosterone can be used as a gel or patch that is applied to the skin, injection into a muscle, tablet that is placed in the cheek, or tablet that is taken by mouth. Common side effects of testosterone include acne, swelling, and breast enlargement in men. Serious side effects may include liver toxicity, heart disease, and behavioral changes. Women and children who are exposed may develop masculinization. It is recommended that individuals with prostate cancer not use the medication. It can cause harm to the baby if used during pregnancy or breastfeeding. Testosterone is in the androgen family of medications. Testosterone was firs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Olympic Committee
The International Olympic Committee (IOC; french: link=no, Comité international olympique, ''CIO'') is a non-governmental sports organisation based in Lausanne, Switzerland. It is constituted in the form of an association under the Swiss Civil Code (articles 60–79). Founded by Pierre de Coubertin and Demetrios Vikelas in 1894, it is the authority responsible for organising the modern ( Summer, Winter, and Youth) Olympic Games. The IOC is the governing body of the National Olympic Committees (NOCs) and of the worldwide "Olympic Movement", the IOC's term for all entities and individuals involved in the Olympic Games. As of 2020, there are 206 NOCs officially recognised by the IOC. The current president of the IOC is Thomas Bach. The stated mission of the IOC is to promote the Olympics throughout the world and to lead the Olympic Movement: *To encourage and support the organization, development, and coordination of sport and sports competitions; *To ensure the regul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polymerase Chain Reaction
The polymerase chain reaction (PCR) is a method widely used to rapidly make millions to billions of copies (complete or partial) of a specific DNA sample, allowing scientists to take a very small sample of DNA and amplify it (or a part of it) to a large enough amount to study in detail. PCR was invented in 1983 by the American biochemist Kary Mullis at Cetus Corporation; Mullis and biochemist Michael Smith, who had developed other essential ways of manipulating DNA, were jointly awarded the Nobel Prize in Chemistry in 1993. PCR is fundamental to many of the procedures used in genetic testing and research, including analysis of ancient samples of DNA and identification of infectious agents. Using PCR, copies of very small amounts of DNA sequences are exponentially amplified in a series of cycles of temperature changes. PCR is now a common and often indispensable technique used in medical laboratory research for a broad variety of applications including biomedical research ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barr Body
A Barr body (named after discoverer Murray Barr) or X-chromatin is an inactive X chromosome in a cell with more than one X chromosome, rendered inactive in a process called lyonization, in species with XY sex-determination (including humans). The Lyon hypothesis states that in cells with multiple X chromosomes, all but one are inactivated during mammalian embryogenesis. This happens early in embryonic development at random in mammals,Brown, C.J., Robinson, W.P., (1997), XIST Expression and X-Chromosome Inactivation in Human Preimplantation Embryos ''Am. J. Hum. Genet.'' 61, 5–8Full Text PDF except in marsupials and in some extra-embryonic tissues of some placental mammals, in which the X chromosome from the sperm is always deactivated. In humans with euploidy, a genotypical female (46, XX karyotype) has one Barr body per somatic cell nucleus, while a genotypical male (46, XY) has none. The Barr body can be seen in the interphase nucleus as a darkly staining small mass ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
True Hermaphroditism
True hermaphroditism, sometimes referred to as ovotesticular syndrome, is an intersex condition in which an individual is born with both ovarian and testicular tissue. Commonly, one or both gonads is an ovotestis containing both types of tissue. Although it is similar in some ways to mixed gonadal dysgenesis, the conditions can be distinguished histologically. Symptoms * Gynecomastia (present in 75% of cases.) History The first medical attempts to document cases appeared in the 16th century. Up until the Late Middle Ages individuals with these conditions were viewed as monsters. Causes There are several ways in which this may occur. * It can be caused by the division of one ovum, followed by fertilization of each haploid ovum and fusion of the two zygotes early in development. * Alternately, an ovum can be fertilized by two sperm followed by trisomic rescue in one or more daughter cells. * Two ova fertilized by two sperm cells will occasionally fuse to form a tetra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disorder Of Sex Development
Disorders of sex development (DSDs), also known as differences in sex development, diverse sex development and variations in sex characteristics (VSC), are congenital conditions affecting the reproductive system, in which development of chromosomal, gonadal, or anatomical sex is atypical. DSDs are subdivided into groups in which the labels generally emphasize the karyotype's role in diagnosis: 46,XX; 46,XY; sex chromosome; XX, sex reversal; ovotesticular disorder; and XY, sex reversal. Overview DSDs are medical conditions encompassing any problem noted at birth where the genitalia are atypical in relation to the chromosomes or gonads. There are several types of DSDs and their effect on the external and internal reproductive organs varies greatly. A frequently-used social and medical adjective for people with DSDs is "intersex". Urologists were concerned that terms like intersex, hermaphrodite, and pseudohermaphrodite were confusing and pejorative. This led to the Chicago Con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
46XX/46XY
46,XX/46,XY is a chimeric genetic condition characterized by the presence of some cells that express a 46,XX karyotype and some cells that express a 46,XY karyotype in a single human being. The cause of the condition lies ''in utero'' with the aggregation of two distinct blastocysts or zygotes (one of which expresses 46,XX and the other of which expresses 46,XY) into a single embryo, which subsequently leads to the development of a single individual with two distinct cell lines, instead of a pair of fraternal twins. 46,XX/46,XY chimeras are the result of the merging of two non-identical twins. This is not to be confused with mosaicism or hybridism, neither of which are chimeric conditions. Since individuals with the condition have two cell lines of the opposite sex, it can also be considered an intersex condition. In humans, sexual dimorphism is a consequence of the XY sex-determination system. In normal prenatal sex differentiation, the male and female embryo is anatomically id ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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