Florence Bell (scientist)
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Florence Bell (scientist)
Florence Ogilvy Bell (1 May 1913 – 23 November 2000), later Florence Sawyer, was a British scientist who contributed to the discovery of the structure of DNA. She was an X-ray crystallography, X-ray crystallographer in the lab of William Astbury. In 1938 they published a paper in ''Nature (journal), Nature'' that described the Nucleic acid structure, structure of DNA as a "Pile of Pennies". Early life Florence Ogilvy Bell was born at 47 Hanover Road, Brondesbury Park, London, the second daughter of Thomas Bell and his wife, Annie Mary Lucas. Her father was a photographer and later advertising manager who had been born in Allendale, Northumberland, and later he moved to Greycotes, Ambleside. Florence grew up in London and attended Haberdashers' Aske's girls' school, Haberdashers' Aske Girls School in Acton, London, Acton, where she was Head girl and head boy, head girl. Education Bell studied Natural Sciences (Cambridge), Natural Sciences at Girton College, Cambridge between ...
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London
London is the capital and largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary down to the North Sea, and has been a major settlement for two millennia. The City of London, its ancient core and financial centre, was founded by the Romans as '' Londinium'' and retains its medieval boundaries.See also: Independent city § National capitals The City of Westminster, to the west of the City of London, has for centuries hosted the national government and parliament. Since the 19th century, the name "London" has also referred to the metropolis around this core, historically split between the counties of Middlesex, Essex, Surrey, Kent, and Hertfordshire, which largely comprises Greater London, governed by the Greater London Authority.The Greater London Authority consists of the Mayor of London and the London Assembly. The London Mayor is distinguished fr ...
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Nucleic Acid
Nucleic acids are biopolymers, macromolecules, essential to all known forms of life. They are composed of nucleotides, which are the monomers made of three components: a 5-carbon sugar, a phosphate group and a nitrogenous base. The two main classes of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). If the sugar is ribose, the polymer is RNA; if the sugar is the ribose derivative deoxyribose, the polymer is DNA. Nucleic acids are naturally occurring chemical compounds that serve as the primary information-carrying molecules in cells and make up the genetic material. Nucleic acids are found in abundance in all living things, where they create, encode, and then store information of every living cell of every life-form on Earth. In turn, they function to transmit and express that information inside and outside the cell nucleus to the interior operations of the cell and ultimately to the next generation of each living organism. The encoded information is ...
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Magnolia Petroleum Company
The Magnolia Petroleum Company was an early twentieth century petroleum company in Texas. The company was established in 1911, being later acquired by the Standard Oil of New York, which operated it as a wholly-owned subsidiary until its demise in 1959. History The company was founded on April 24, 1911, by the Sealy family of Galveston, as a consolidation of several earlier companies, including J. S. Cullinan Company and its refinery in the East Texas Oil Field. Standard Oil of New York ("Socony") exchanged its stock for all of the Magnolia stock (except seven shares for the Directors) in December 1925 though it continued to operate as an affiliate of Socony. The firm then merged with Vacuum Oil Company in 1931, becoming "Socony-Vacuum Oil Company". Magnolia Petroleum continued to operate as a subsidiary of Socony-Vacuum. In 1959, Magnolia was fully incorporated into the Mobil division of Socony-Vacuum, which later changed its name to 'Socony Mobil' and, ultimately to Mobil ...
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Ambleside
Ambleside is a town and former civil parish, now in the parish of Lakes, Cumbria, Lakes, in Cumbria, in North West England. Historic counties of England, Historically in Westmorland, it marks the head (and sits on the east side of the northern headwater) of Windermere, England's largest natural lake. In the Lake District National Park, it is south of the highest road pass in the Lake District, Kirkstone Pass and both places are the meeting point of well-marked paths and mountain hiking trails. In 2020 it had an estimated population of 2596. In 1961 the parish had a population of 2562. Economy Local government services Ambleside is co-administered by South Lakeland District Council and in minor matters forms part of the Lakes, Cumbria, Lakes Civil parishes in England, civil parish. The other main co-administration is Cumbria County Council. Ambleside was formerly a Township (England), township, in 1866 Ambleside became a civil parish in its own right until it was abolished on 1 ...
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War Office
The War Office was a department of the British Government responsible for the administration of the British Army between 1857 and 1964, when its functions were transferred to the new Ministry of Defence (MoD). This article contains text from this source, which is available under th Open Government Licence v3.0 © Crown copyright It was equivalent to the Admiralty, responsible for the Royal Navy (RN), and (much later) the Air Ministry, which oversaw the Royal Air Force (RAF). The name 'War Office' is also given to the former home of the department, located at the junction of Horse Guards Avenue and Whitehall in central London. The landmark building was sold on 1 March 2016 by HM Government for more than £350 million, on a 250 year lease for conversion into a luxury hotel and residential apartments. Prior to 1855, 'War Office' signified the office of the Secretary at War. In the 17th and 18th centuries, a number of independent offices and individuals were re ...
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Women's Auxiliary Air Force
The Women's Auxiliary Air Force (WAAF), whose members were referred to as WAAFs (), was the female auxiliary of the Royal Air Force during World War II. Established in 1939, WAAF numbers exceeded 180,000 at its peak strength in 1943, with over 2,000 women enlisting per week. History A Women's Royal Air Force had existed from 1918 to 1920. The WAAF was created on 28 June 1939, absorbing the forty-eight RAF companies of the Auxiliary Territorial Service which had existed since 1938. Conscription of women did not begin until 1941. It only applied to those between 20 and 30 years of age and they had the choice of the auxiliary services or factory work. Women recruited into the WAAF were given basic training at one of five sites, though not all of the sites ran training simultaneously. The five sites were at West Drayton, Harrogate, Bridgnorth, Innsworth and Wilmslow. All WAAF basic recruit training was located at Wilmslow from 1943. WAAFs did not serve as aircrew. The use of women ...
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Raymond Gosling
Raymond George Gosling (15 July 1926 – 18 May 2015) was a British scientist. While a PhD student at King's College, London he worked under the supervision of Maurice Wilkins and Rosalind Franklin. The crystallographic experiments of Franklin and Gosling, together with others by Wilkins, produced data that helped James Watson and Francis Crick to infer the structure of DNA. Early years He was born in 1926 and attended school in Wembley. He studied physics at University College London from 1944 to 1947 and became a hospital physicist at the King's Fund and Middlesex Hospital between 1947 and 1949 before joining King's College London as a research student, from which he eventually received his PhD. Career Work at King's College London and DNA When he arrived at King's College London, Gosling was directed by Sir John Randall to work on the problem of the structure of DNA. Randall was convinced that DNA was the material which transmitted the genetic code. Randall assigned h ...
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Photo 51
' ''Photo 51'' is an X-ray based fiber diffraction image of a paracrystalline gel composed of DNA fiber taken by Raymond Gosling, a graduate student working under the supervision of Rosalind Franklin in May 1952 at King's College London, while working in Sir John Randall's group. The image was tagged "photo 51" because it was the 51st diffraction photograph that Franklin and Gosling had taken. It was critical evidence in identifying the structure of DNA. Use in discovering structure of DNA According to Raymond Gosling's later account, although photo 51 was an exceptionally clear diffraction pattern of the "B" form of DNA, Franklin was more interested in solving the diffraction pattern of the "A" form of DNA, so she put Gosling's photo 51 to the side. When it had been decided that Franklin would leave King's College, she suggested that Gosling show the photograph to Maurice Wilkins (who would become Gosling's advisor after Franklin left). A few days later, Wilkins showed the ...
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Nucleic Acid Double Helix
Nucleus ( : nuclei) is a Latin word for the seed inside a fruit. It most often refers to: *Atomic nucleus, the very dense central region of an atom *Cell nucleus, a central organelle of a eukaryotic cell, containing most of the cell's DNA Nucleus may also refer to: Science, technology, and mathematics Astronomy *Active galactic nucleus in astronomy *Comet nucleus, the solid, central part of a comet Biology *Cell nucleus, a central organelle of a eukaryotic cell, containing most of the cell's DNA *Nucleus (neuroanatomy), a cluster of cell bodies of neurons in the central nervous system *Nucleus that forms in the eye in nuclear sclerosis (early cataracts) *''Nucleus'', a scientific journal concerned with the cell nucleus; published by Taylor & Francis *Nucleus, a small colony of honeybees, induced to raise a new queen by the beekeeper Computer systems * Nucleus (operating system), sometimes a synonym for kernel * Nucleus CMS, a weblog system * Nucleus RTOS, a real-time oper ...
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A-DNA
A-DNA is one of the possible double helical structures which DNA can adopt. A-DNA is thought to be one of three biologically active double helical structures along with B-DNA and Z-DNA. It is a right-handed double helix fairly similar to the more common B-DNA form, but with a shorter, more compact helical structure whose base pairs are not perpendicular to the helix-axis as in B-DNA. It was discovered by Rosalind Franklin, who also named the A and B forms. She showed that DNA is driven into the A form when under dehydrating conditions. Such conditions are commonly used to form crystals, and many DNA crystal structures are in the A form. The same helical conformation occurs in double-stranded RNAs, and in DNA-RNA hybrid double helices. Structure Like the more common B-DNA, A-DNA is a right-handed double helix with major and minor grooves. However, as shown in the comparison table below, there is a slight increase in the number of base pairs (bp) per turn. This results in a smal ...
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Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution with research programs focusing on cancer, neuroscience, plant biology, genomics, and quantitative biology. It is one of 68 institutions supported by the Cancer Centers Program of the U.S. National Cancer Institute (NCI) and has been an NCI-designated Cancer Center since 1987. The Laboratory is one of a handful of institutions that played a central role in the development of molecular genetics and molecular biology. It has been home to eight scientists who have been awarded the Nobel Prize in Physiology or Medicine. CSHL is ranked among the leading basic research institutions in molecular biology and genetics with Thomson Reuters ranking it #1 in the world. CSHL was also ranked #1 in research output worldwide by ''Nature''. The Laboratory is led by Bruce Stillman, a biochemist and cancer researcher. Since its inception in 1890, the institution's campus on the North Shore of Long Island has also been ...
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Tobacco Mosaic Virus
''Tobacco mosaic virus'' (TMV) is a positive-sense single-stranded RNA virus species in the genus ''Tobamovirus'' that infects a wide range of plants, especially tobacco and other members of the family Solanaceae. The infection causes characteristic patterns, such as "mosaic"-like mottling and discoloration on the leaves (hence the name). TMV was the first virus to be discovered. Although it was known from the late 19th century that a non-bacterial infectious disease was damaging tobacco crops, it was not until 1930 that the infectious agent was determined to be a virus. It is the first pathogen identified as a virus. The virus was crystallised by W.M. Stanley. It has a similar size to the largest synthetic molecule, known as PG5 History In 1886, Adolf Mayer first described the tobacco mosaic disease that could be transferred between plants, similar to bacterial infections. In 1892, Dmitri Ivanovsky gave the first concrete evidence for the existence of a non-bacterial infect ...
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