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FOP Friends
FOP Friends, formerly Friends of Oliver, is a registered charity in the United Kingdom established on 1 March 2012. It aims to raise funds that are needed to find effective treatments for the rare genetic condition Fibrodysplasia Ossificans Progressiva (FOP). The charity also works to raise awareness and understanding of FOP amongst medical communities and the general public. History Friends of Oliver was founded when Chris and Helen Bedford-Gay received the diagnosis that their son Oliver had the rare genetic condition fibrodysplasia ossificans progressiva, or FOP. With FOP being such a rare disease, there was no UK charity dedicated to raising funds for research into effective treatments/a cure for the condition. Chris, along with his sisters-in-law Alison and Rachel, were the founding trustees of the charity. The original intention of Friends of Oliver was to keep family and friends updated with breakthrough news, to thank them for their continued support, and to celebrate Ol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Europe, off the north-western coast of the continental mainland. It comprises England, Scotland, Wales and Northern Ireland. The United Kingdom includes the island of Great Britain, the north-eastern part of the island of Ireland, and many smaller islands within the British Isles. Northern Ireland shares a land border with the Republic of Ireland; otherwise, the United Kingdom is surrounded by the Atlantic Ocean, the North Sea, the English Channel, the Celtic Sea and the Irish Sea. The total area of the United Kingdom is , with an estimated 2020 population of more than 67 million people. The United Kingdom has evolved from a series of annexations, unions and separations of constituent countries over several hundred years. The Treaty of Union between the Kingdom of England (which included Wales, annexed in 1542) and the Kingdom of Scotland in 170 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibrodysplasia Ossificans Progressiva
Fibrodysplasia ossificans progressiva (; FOP; also called Münchmeyer disease and formerly called myositis ossificans progressiva or Stoneman disease) is an extremely rare connective tissue disease in which fibrous connective tissue such as muscle, tendons, and ligaments turn into bone tissue. It is the only known medical condition where one organ system changes into another. It is a severe, disabling disorder with no current cure or treatment. FOP is caused by a mutation of the gene ACVR1. The mutation affects the body's repair mechanism, causing fibrous tissue including muscle, tendons, and ligaments to become ossified, either spontaneously or when damaged as the result of trauma. In many cases, otherwise minor injuries can cause joints to become permanently fused as new bone forms, replacing the damaged muscle tissue. This new bone formation (known as "heterotopic ossification") eventually forms a secondary skeleton and progressively restricts the patient's ability to move. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charitable Organization
A charitable organization or charity is an organization whose primary objectives are philanthropy and social well-being (e.g. educational, Religion, religious or other activities serving the public interest or common good). The legal definition of a charitable organization (and of charity) varies between countries and in some instances regions of the country. The Charity regulators, regulation, the tax treatment, and the way in which charity law affects charitable organizations also vary. Charitable organizations may not use any of their funds to profit individual persons or entities. (However, some charitable organizations have come under scrutiny for spending a disproportionate amount of their income to pay the salaries of their leadership). Financial figures (e.g. tax refund, revenue from fundraising, revenue from sale of goods and services or revenue from investment) are indicators to assess the financial sustainability of a charity, especially to charity evaluators. This ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Oxford
, mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor = The Lord Patten of Barnes , vice_chancellor = Louise Richardson , students = 24,515 (2019) , undergrad = 11,955 , postgrad = 12,010 , other = 541 (2017) , city = Oxford , country = England , coordinates = , campus_type = University town , athletics_affiliations = Blue (university sport) , logo_size = 250px , website = , logo = University of Oxford.svg , colours = Oxford Blue , faculty = 6,995 (2020) , academic_affiliations = , The University of Oxford is a collegiate research university in Oxf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Pennsylvania
The University of Pennsylvania (also known as Penn or UPenn) is a private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest-regarded universities by numerous organizations and scholars. While the university dates its founding to 1740, it was created by Benjamin Franklin and other Philadelphia citizens in 1749. It is a member of the Ivy League. The university has four undergraduate schools as well as twelve graduate and professional schools. Schools enrolling undergraduates include the College of Arts and Sciences, the School of Engineering and Applied Science, the Wharton School, and the School of Nursing. Among its highly ranked graduate schools are its law school, whose first professor wrote the first draft of the United States Constitution, its medical school, the first in North America, and Wharton, the first collegiate business school. Penn's endowment is US$20.7 billio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International FOP Association
The International Fibrodysplasia Ossificans Progressiva Association (IFOPA) is a US-based 501(c)(3) non-profit organization supporting medical research, education and communication for those afflicted by the rare genetic condition Fibrodysplasia Ossificans Progressiva (FOP). IFOPA's mission is to fund research to find a cure for FOP while supporting, connecting, and advocating for individuals with FOP and their families, and raising awareness worldwide. IFOPA is governed by a volunteer board of directors which may range in number from 9 to 15, at least one of whom must have FOP. The association's location is 1520 Clay St., Suite H2, North Kansas City, MO, 64116, part of the Kansas City, Missouri metropolitan area. Founding and history IFOPA was founded in 1988 by Jeannie L. Peeper. Diagnosed with FOP in 1962 at age four, Peeper graduated from college in 1985 with a bachelor of arts degree in social work. Michael Zasloff, then at the National Institutes of Health (NIH), was stu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frederick Kaplan
Frederick S. Kaplan is an American medical doctor specializing in research of musculoskeletal disorders such as fibrodysplasia ossificans progressiva (FOP). Education Frederick Kaplan received a bachelor's degree from Johns Hopkins University in 1972. He also obtained his Doctor of Medicine (MD) from Johns Hopkins University, graduating in 1976. FOP research In the mid 1980s, Kaplan met David Romanoff, the medical director of the Inglis House—a residential care facility for adults with disabilities. Two residents of the facility were diagnosed with fibrodysplasia ossificans progressiva (FOP), a very rare medical condition in which the soft tissue of the body ossifies, or turns to bone, over time. Romanoff was "grappling" with caring for the patients, and asked Kaplan if he would like to meet them, which he did. This was his first encounter with the disease beyond reading about it. In 1988, Kaplan met immunologist and geneticist Michael Zasloff; Zasloff introduced him to a p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eileen Shore
Eileen M. Shore is an American medical researcher and geneticist specializing in research of muscoskeletal disorders such as fibrodysplasia ossificans progressiva. Education Shore received her bachelor's degree in biology from the University of Notre Dame in 1976. She then earned a Master of Arts in biology at Indiana University in 1978. Subsequently, she received her PhD from the University of Pennsylvania in cell and molecular biology in 1987. FOP research Shore undertakes research into fibrodysplasia ossificans progressiva (FOP), a genetic disease that causes bone tissue to form outside the skeleton, known as heterotopic ossification. In 1992, Shore and Frederick Kaplan initiated the FOP Research Laboratory. Kaplan hired Shore because of her experience as a geneticist—she researched fruit fly larvae as a graduate student and studied mammalian embryology as a postdoctoral researcher. In 2006, Shore and Kaplan published their findings on the genetic mutation that causes F ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jeans For Genes
Jeans for Genes Day is a national fundraiser held in Australia and the United Kingdom.The two fundraisers are not associated with one another and raise money for different organisations. Jeans for Genes (Australia) In Australia, Jeans for Genes was founded by the Children’s Medical Research Institute (CMRI) in 1994. Jeans for Genes (United Kingdom) In the United Kingdom, The CGD Research Trust and Support Group was founded as a charity in 1991 by New Zealander, Ocean Numan, (Paul), with the aim of finding a cure for Chronic Granulomatous Disease (CGD) for his son and other CGD boys through gene therapy. This relatively new form of treatment still remains the greatest creator of hope that inherited diseases will be finally conquered. One of the Trust's dedicated supporters, Rosemarie Rymer, came up with the original idea of wearing jeans, for the benefit of your genes, one day in the year, and paying a gold coin donation to the national appeal. The first UK Jeans for Genes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ACVR1
Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ''ACVR1'' gene; also known as ALK-2 (activin receptor-like kinase-2). ACVR1 has been linked to the 2q23-24 region of the genome. This protein is important in the bone morphogenic protein (BMP) pathway which is responsible for the development and repair of the skeletal system. While knock-out models with this gene are in progress, the ACVR1 gene has been connected to fibrodysplasia ossificans progressiva, a disease characterized by the formation of heterotopic bone throughout the body. It is a bone morphogenetic protein receptor, type 1. Function Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Katie Thistleton
Katie Lorna Thistleton (born 13 May 1989) is an English television and radio presenter, National Council for the Training of Journalists (NCTJ) qualified journalist and author, best known for her work across the CBBC channel. She presents a show on BBC Radio 1 with her co-presenter Vick Hope. Early life Born in Manchester, Thistleton attended Droylsden High School for Girls. Thistleton graduated from the University of Salford with a degree in English and Creative Writing along with fellow star Lauren Layfield, before qualifying as a NCTJ certified journalist after studying at News Associates, Manchester. Thistleton previously worked for the NHS Pennine Care mental health trust. Career Television Thistleton is best known for her work presenting in CBBC HQ, hosting the live 'bits in between the shows'. She has done this since she was headhunted for the job in 2013 whilst working behind the scenes for CBBC as a PA and Researcher. She hosts the ''CBBC Book Club'' on the ''CBBC' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Casualty (TV Series)
''Casualty'' (stylised as ''CASUAL+Y'') is a British medical drama series that airs weekly on BBC One. Created by Jeremy Brock and Paul Unwin, it was first broadcast in the United Kingdom on BBC One on 6 September 1986. The original producer was Geraint Morris. Having been broadcast weekly since 1986, ''Casualty'' is the longest-running primetime medical drama series in the world. The programme is set in the fictional Holby City Hospital and focuses on the staff and patients of the hospital's Accident and Emergency (A&E) Department. The show has strong ties to its sister programme '' Holby City'', which began as a spin-off series from ''Casualty'' in 1999, set in the same hospital. The final episode of ''Holby City'' was broadcast in March 2022. ''Casualty''s exterior shots were mainly filmed outside the Ashley Down Centre in Bristol from 1986 until 2002, when they moved to the centre of Bristol. In 2011, ''Casualty'' celebrated its 25th anniversary and moved production to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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