FcεRI Receptor
The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-Affinity (pharmacology), affinity receptor (biochemistry), receptor for the Fc region of immunoglobulin E (IgE), an antibody Isotype (immunology), isotype involved in allergy disorders and parasitism, parasite immunity. FcεRI is a tetrameric protein, tetrameric receptor complex that binds Fc portion of the ε Immunoglobulin heavy chain, heavy chain of IgE. It consists of one alpha (FCER1A, FcεRIα – antibody binding site), one beta (FCER1B, FcεRIβ – which amplifies the downstream signal), and two gamma chains (FCER1G, FcεRIγ – the site where the downstream signal initiates) connected by two disulfide bridges on Mast cell, mast cells and Basophil, basophils. It lacks the beta subunit on other cells. It is constitutively expressed on mast cells and basophils and is inducible in Eosinophil, eosinophils. Tissue distribution FcεRI is found on epidermal Langerhans cells, eosinophils, ma ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]