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Family TreeDNA
FamilyTreeDNA is a division of Gene by Gene, a commercial genetic testing company based in Houston, Texas. FamilyTreeDNA offers analysis of autosomal DNA, Y-DNA, and mitochondrial DNA to individuals for genealogical purpose. With a database of more than two million records, it is the most popular company worldwide for Y-DNA and mitochondrial DNA, and the fourth most popular for autosomal DNA. In Europe, it is the most common also for autosomal DNA. FamilyTreeDNA as a division of Gene by Gene were acquired by MYDNA, Inc., an Australian company, in January 2021. History Concept and founding (2000–2002) FamilyTreeDNA was founded based on an idea conceived by Bennett Greenspan, a lifelong entrepreneur and genealogy enthusiast. In 1999, Greenspan had entered semi-retirement and was working on his family history. He began work on his mother's Nitz lineage. When faced with a roadblock in his work, he remembered two cases of genetics being used to prove ancestry that had recen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Houston
Houston ( ) is the List of cities in Texas by population, most populous city in the U.S. state of Texas and in the Southern United States. Located in Southeast Texas near Galveston Bay and the Gulf of Mexico, it is the county seat, seat of Harris County, Texas, Harris County, as well as the principal city of the Greater Houston metropolitan area, the fifth-most populous metropolitan statistical area in the United States and the List of Texas metropolitan areas, second-most populous in Texas after Dallas–Fort Worth metroplex, Dallas–Fort Worth. With a population of 2,314,157 in 2023, Houston is the List of United States cities by population, fourth-most populous city in the United States after New York City, Los Angeles, and Chicago, and the List of North American cities by population, sixth-most populous city in North America. Houston is the southeast anchor of the greater megaregion known as the Texas Triangle. Comprising a land area of , Houston is the List of United S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mission Viejo, California
Mission Viejo ( ; language change, corruption of ; ) is a Commuter town, commuter city in the Saddleback Valley in Orange County, California, United States. Mission Viejo is considered one of the largest Planned community, master-planned communities ever built under a single project in the United States and is rivaled only by Highlands Ranch, Highlands Ranch, Colorado in size. Its population as of 2020 was 93,653. Mission Viejo is suburban in nature and culture, and consists of residential properties, offices and businesses. The city is noted for its tree-lined neighborhoods, receiving recognition from the National Arbor Day Foundation. The city's name is a reference to Rancho Mission Viejo, a large Spanish land grant from which the community was founded. The United States Census Bureau defines an urban area of Orange County cities not part of Los Angeles's urban area with Mission Viejo as the principal city: the Mission Viejo–Lake Forest, California, Lake Forest–Laguna Ni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lake Forest, California
Lake Forest is a city in Orange County, California, United States. The population was 85,858 at the 2020 United States census, 2020 census. Lake Forest incorporated as a city on December 20, 1991. Prior to incorporation, the community had been known as El Toro. Following a vote in 2000, Lake Forest expanded its city limits to include the master-planned developments of Foothill Ranch and Portola Hills. This expansion brought new homes and commercial centers to the northeastern boundary of the city. Lake Forest has two lakes from which the city gets its name. The lakes are man-made, and condominiums and custom homes ranging from large to small line their shores. Neighborhood associations manage the lakes (Lake 1, known as the Lake Forest Beach and Tennis Club, and Lake 2, the Sun and Sail Club.) Each facility features tennis courts, gyms, basketball courts, barbecue pits, volleyball courts, multiple swimming pools, saunas, hot tubs and club houses for social events. The "fores ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Forensic Genealogy
Investigative genetic genealogy, also known as forensic genetic genealogy, is the emerging practice of utilizing genetic information from direct-to-consumer companies for identifying suspects or victims in criminal cases. As of December 2023, the use of this technology has solved a total of 651 criminal cases, including 318 individual perpetrators who were brought to light. There have also been 464 decedents identified, as well as 4 living Does. The investigative power of genetic genealogy revolves around the use of publicly accessible genealogy databases such as GEDMatch and Family TreeDNA. On GEDMatch, users are able to upload their genetic data from any direct-to-consumer company in an effort to identify relatives that have tested at companies other than their own. Identifying unknown subjects through investigative genetic genealogy is done through the use of analysis of identity-by-descent (IBD) segments of DNA that indicate shared ancestors. Data available in GEDMatch, wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Helix (genomics Company)
Helix is an American population genomics company. History Helix focuses on personal genomics and citizen science. Helix has a marketplace that offers applications created by approved partners. Helix handles sample collection, DNA sequencing, and secure data storage and partners develop on-demand products. Helix is headquartered in the San Francisco Bay Area and operates a sequencing laboratory in San Diego. In 2016, Helix partnered with the National Geographic Society to sequence DNA for the Genographic Project. In 2018, Helix partnered with the Desert Research Institute and Renown Institute of Health Innovation in support of the Healthy Nevada project, which offers free access to genomic sequencing to 40,000 residents of northern Nevada for health research. Sequencing methodology Helix uses NGS to sequence a proprietary assay called Exome+, a version of Exome sequencing which according to the company provides 100 times more data than was previously available. Exome+ incl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genographic Project
The Genographic Project, launched on 13 April 2005 by the National Geographic Society and IBM, was a Molecular anthropology, genetic anthropological study (sales discontinued on 31 May 2019) that aimed to map historical human migrations patterns by collecting and analyzing DNA samples. The final phase of the project was Geno 2.0 Next Generation. Upon retirement of the site, 1,006,543 participants in over 140 countries had joined the project. Project history Beginnings Created and led by project director Spencer Wells in 2005, the Genographic Project was a privately funded, not-for-profit collaboration between the National Geographic Society, IBM and the Waitt Foundation. Field researchers at eleven regional centers around the world began by collecting DNA samples from Indigenous peoples, indigenous populations. Since the fall of 2015, the Project was led by Miguel Vilar. In fall 2012, the Genographic Project announced the completion of a new genotyping array, dedicated to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypervariable Region
A hypervariable region (HVR) is a location within a sequence where polymorphisms frequently occur. It is used in two contexts: * In the case of nucleic acids, an HVR is where base pairs frequently change. This can be due to a change in the number of repeats (which is seen in eukaryotic nuclear DNA) or simply low selective pressure allowing a great number of substitutions and indels (as in the case of mitochondrial DNA D-loop and 16S rRNA). * In the case of antibodies, an HVR is where most of the differences among antibodies occur. This region is also called the complementarity-determining region. Because there already is a separate article for the antibody region, this article will focus on the nucleic acid case. Mitochondrial There are two mitochondrial hypervariable regions used in human mitochondrial genealogical DNA testing. HVR1 is considered a "low resolution" region and HVR2 is considered a "high resolution" region. Getting HVR1 and HVR2 DNA tests can help determine one ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitochondrial DNA
Mitochondrial DNA (mtDNA and mDNA) is the DNA located in the mitochondrion, mitochondria organelles in a eukaryotic cell that converts chemical energy from food into adenosine triphosphate (ATP). Mitochondrial DNA is a small portion of the DNA contained in a eukaryotic cell; most of the DNA is in the cell nucleus, and, in plants and algae, the DNA also is found in plastids, such as chloroplasts. Mitochondrial DNA is responsible for coding of 13 essential subunits of the complex oxidative phosphorylation (OXPHOS) system which has a role in cellular energy conversion. Human mitochondrial DNA was the first significant part of the human genome to be sequenced. This sequencing revealed that human mtDNA has 16,569 base pairs and encodes 13 proteins. As in other vertebrates, the human mitochondrial genetic code differs slightly from nuclear DNA. Since animal mtDNA evolves faster than nuclear genetic markers, it represents a mainstay of phylogenetics and evolutionary biology. It als ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Y-chromosome DNA Haplogroup
In human genetics, a human Y-chromosome DNA haplogroup is a haplogroup defined by specific mutations in the non-Genetic recombination, recombining portions of DNA on the male-specific Y chromosome (Y-DNA). Individuals within a haplogroup share similar numbers of short tandem repeats (STRs) and single-nucleotide polymorphisms (SNPs). The Y-chromosome accumulates approximately two mutations per generation, "one mutation in every 30 million base pairs" and Y-DNA haplogroups represent significant branches of the Y-chromosome phylogenetic tree, each characterized by hundreds or even thousands of unique mutations. The Y-chromosomal most recent common ancestor (Y-MRCA), often referred to as Y-chromosomal Adam, is the most recent common ancestor from whom all currently living humans are descended Patrilineality, patrilineally. Y-chromosomal Adam is estimated to have lived around 236,000 years ago in Africa. By examining other population bottlenecks, most Eurasian men trace their descent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Affymetrix
Affymetrix is now Applied Biosystems, a brand of DNA microarray products sold by Thermo Fisher Scientific that originated with an American biotechnology research and development and manufacturing company of the same name. The Santa Clara, California-based Affymetrix, Inc. now a part of Thermo Fisher Scientific was co-founded by Alex Zaffaroni and Stephen Fodor. Stephen Fodor and his group, based on their earlier development of methods to fabricate DNA microarrays using semiconductor manufacturing techniques. In 1994, the company's first product under the "GeneChip" Affymetrix trademark, an HIV genotyping chip was introduced, and the company went public in 1996. After incorporation, Affymetrix grew in part by acquiring technologies from other companies, including Genetic MicroSystems (slide-based Microarrays and scanners) and Neomorphic (for bioinformatics) in 2000, ParAllele Bioscience (custom SNP genotyping), USB/Anatrace (biochemical reagents) in 2008, Panomics (low to mi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Microarray
A DNA microarray (also commonly known as a DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome. Each DNA spot contains picomoles (10−12 moles) of a specific DNA sequence, known as '' probes'' (or ''reporters'' or '' oligos''). These can be a short section of a gene or other DNA element that are used to hybridize a cDNA or cRNA (also called anti-sense RNA) sample (called ''target'') under high-stringency conditions. Probe-target hybridization is usually detected and quantified by detection of fluorophore-, silver-, or chemiluminescence-labeled targets to determine relative abundance of nucleic acid sequences in the target. The original nucleic acid arrays were macro arrays approximately 9 cm × 12 cm and the first computerized image based analysis was published in 1981. It was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
