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FamilyTreeDNA
FamilyTreeDNA is a division of Gene by Gene, a commercial genetic testing company based in Houston, Texas. FamilyTreeDNA offers analysis of autosomal DNA, Y-DNA, and mitochondrial DNA to individuals for genealogical purpose. With a database of more than two million records, it is the most popular company worldwide for Y-DNA and mitochondrial DNA, and the fourth most popular for autosomal DNA. In Europe, it is the most common also for autosomal DNA. FamilyTreeDNA as a division of Gene by Gene were acquired by MYDNA, Inc., an Australian company, in January 2021. History Concept and founding (2000–2002) FamilyTreeDNA was founded based on an idea conceived by Bennett Greenspan, a lifelong entrepreneur and genealogy enthusiast. In 1999, Greenspan had entered semi-retirement and was working on his family history. He began work on his mother's Nitz lineage. When faced with a roadblock in his work, he remembered two cases of genetics being used to prove ancestry that had recently ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MyHeritage
MyHeritage is an online genealogy platform with web, mobile, and Genealogy software, software products and services, introduced by the Israeli company MyHeritage in 2003. Users of the platform can obtain their family trees, upload and browse through photos, and search through over 19.9 billion Public records, historical records, among other features. In early 2021 they were acquired by Francisco Partners an private equity firm for $600 million. As of 2023, the service supports 42 languages. In 2016, it launched a genetic testing service called MyHeritage DNA, with more than 6.5 million DNA kits in the company's database by March 2023.MyHeritage Launches 3rd DNA Quest Initiative to Help Adoptees Find Their Birth Families Yahoo! Fina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene By Gene
Gene by Gene is a commercial genetic testing company based in Houston, Texas. The company was owned by Bennett Greenspan and Max Blankfeld, and was the parent company of Family Tree DNA. In January 2021, Gene by Gene was acquired by US based parent company myDNA Inc. Gene by Gene and Australia company myDNA Life Private Ltd. are both subsidiaries of parent company, myDNA Inc. The current Chief Executive Officer of myDNA Inc. is, Dr Lior Rauchberger. History Genealogy by Genetics, Ltd. was formed in 2000 with the creation of FamilyTreeDNA. In September 2012, Greenspan and Blankfeld restructured the company and renamed it Gene by Gene, Ltd. After restructuring, the business comprises four divisions; DNA DTC, DNA Findings, DNA Traits, and Family Tree DNA. FamilyTreeDNA Family Tree DNA was the first commercial company to develop DNA testing for genealogical purposes. It has been operational since April 2000. The Genomics Research Center Family Tree DNA originally partnered with t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Forensic Genealogy
Investigative genetic genealogy, also known as forensic genetic genealogy, is the emerging practice of utilizing genetic information from direct-to-consumer companies for identifying suspects or victims in criminal cases. As of December 2023, the use of this technology has solved a total of 651 criminal cases, including 318 individual perpetrators who were brought to light. There have also been 464 decedents identified, as well as 4 living Does. The investigative power of genetic genealogy revolves around the use of publicly accessible genealogy databases such as GEDMatch and Family TreeDNA. On GEDMatch, users are able to upload their genetic data from any direct-to-consumer company in an effort to identify relatives that have tested at companies other than their own. Identifying unknown subjects through investigative genetic genealogy is done through the use of analysis of identity-by-descent (IBD) segments of DNA that indicate shared ancestors. Data available in GEDMatch, wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bennett Greenspan
Bennett C. Greenspan (born 1952) is an American businessman. His business ventures have covered industries from real estate to the .com boom. Though he has mainly worked in the fields of photography and genetic testing, he is best known for his pioneering work in genetic genealogy. Greenspan founded Family Tree DNA which was the first American company to offer genealogical DNA testing directly to the general public. He is currently the president and chief executive officer (CEO) and also the managing partner of Family Tree DNA's parent company Gene by Gene. Greenspan is also the project administrator of several surname DNA projects, and regularly lectures on the use of genetics in genealogy and on genomics. Personal life A Jewish American, Greenspan was born in Omaha, Nebraska to Maurice and Rosalie Greenspan. He and his brother were raised there. As a young child, Greenspan had a love of family history and would interview the oldest members of his family during gatherings. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genealogical DNA Test
A genealogical DNA test is a DNA-based Genetic testing, genetic test used in genetic genealogy that looks at specific locations of a person's genome in order to find or verify ancestral genealogical relationships, or (with lower reliability) to estimate the ethnicity, ethnic mixture of an individual. Since different testing companies use different ethnic reference groups and different matching algorithms, ethnicity estimates for an individual vary between tests, sometimes dramatically. Three principal types of genealogical DNA tests are available, with each looking at a different part of the genome and being useful for different types of genealogical research: Genealogical DNA test#Autosomal DNA (atDNA) testing, autosomal (atDNA), Genealogical DNA test#Mitochondrial DNA (mtDNA) testing, mitochondrial (mtDNA), and Genealogical DNA test#Y-chromosome (Y-DNA) testing, Y-chromosome (Y-DNA). Autosomal tests may result in a large number of DNA matches to both males and females who have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Genealogy
Genetic genealogy is the use of genealogical DNA tests, i.e., DNA profiling and DNA testing, in combination with traditional genealogical methods, to infer genetic relationships between individuals. This application of genetics came to be used by family historians in the 21st century, as DNA tests became affordable. The tests have been promoted by amateur groups, such as Surname DNA project, surname study groups or regional genealogical groups, as well as research projects such as the Genographic Project. about 30 million people had been tested. As the field developed, the aims of practitioners broadened, with many seeking knowledge of their ancestry beyond the recent centuries, for which traditional pedigrees can be constructed. History The investigation of surnames in genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Y-chromosome DNA Haplogroup
In human genetics, a human Y-chromosome DNA haplogroup is a haplogroup defined by specific mutations in the non-Genetic recombination, recombining portions of DNA on the male-specific Y chromosome (Y-DNA). Individuals within a haplogroup share similar numbers of short tandem repeats (STRs) and single-nucleotide polymorphisms (SNPs). The Y-chromosome accumulates approximately two mutations per generation, "one mutation in every 30 million base pairs" and Y-DNA haplogroups represent significant branches of the Y-chromosome phylogenetic tree, each characterized by hundreds or even thousands of unique mutations. The Y-chromosomal most recent common ancestor (Y-MRCA), often referred to as Y-chromosomal Adam, is the most recent common ancestor from whom all currently living humans are descended Patrilineality, patrilineally. Y-chromosomal Adam is estimated to have lived around 236,000 years ago in Africa. By examining other population bottlenecks, most Eurasian men trace their descent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitochondrial DNA
Mitochondrial DNA (mtDNA and mDNA) is the DNA located in the mitochondrion, mitochondria organelles in a eukaryotic cell that converts chemical energy from food into adenosine triphosphate (ATP). Mitochondrial DNA is a small portion of the DNA contained in a eukaryotic cell; most of the DNA is in the cell nucleus, and, in plants and algae, the DNA also is found in plastids, such as chloroplasts. Mitochondrial DNA is responsible for coding of 13 essential subunits of the complex oxidative phosphorylation (OXPHOS) system which has a role in cellular energy conversion. Human mitochondrial DNA was the first significant part of the human genome to be sequenced. This sequencing revealed that human mtDNA has 16,569 base pairs and encodes 13 proteins. As in other vertebrates, the human mitochondrial genetic code differs slightly from nuclear DNA. Since animal mtDNA evolves faster than nuclear genetic markers, it represents a mainstay of phylogenetics and evolutionary biology. It als ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Microarray
A DNA microarray (also commonly known as a DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome. Each DNA spot contains picomoles (10−12 moles) of a specific DNA sequence, known as '' probes'' (or ''reporters'' or '' oligos''). These can be a short section of a gene or other DNA element that are used to hybridize a cDNA or cRNA (also called anti-sense RNA) sample (called ''target'') under high-stringency conditions. Probe-target hybridization is usually detected and quantified by detection of fluorophore-, silver-, or chemiluminescence-labeled targets to determine relative abundance of nucleic acid sequences in the target. The original nucleic acid arrays were macro arrays approximately 9 cm × 12 cm and the first computerized image based analysis was published in 1981. It was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Affymetrix
Affymetrix is now Applied Biosystems, a brand of DNA microarray products sold by Thermo Fisher Scientific that originated with an American biotechnology research and development and manufacturing company of the same name. The Santa Clara, California-based Affymetrix, Inc. now a part of Thermo Fisher Scientific was co-founded by Alex Zaffaroni and Stephen Fodor. Stephen Fodor and his group, based on their earlier development of methods to fabricate DNA microarrays using semiconductor manufacturing techniques. In 1994, the company's first product under the "GeneChip" Affymetrix trademark, an HIV genotyping chip was introduced, and the company went public in 1996. After incorporation, Affymetrix grew in part by acquiring technologies from other companies, including Genetic MicroSystems (slide-based Microarrays and scanners) and Neomorphic (for bioinformatics) in 2000, ParAllele Bioscience (custom SNP genotyping), USB/Anatrace (biochemical reagents) in 2008, Panomics (low to mi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Helix (genomics Company)
Helix is an American population genomics company. History Helix focuses on personal genomics and citizen science. Helix has a marketplace that offers applications created by approved partners. Helix handles sample collection, DNA sequencing, and secure data storage and partners develop on-demand products. Helix is headquartered in the San Francisco Bay Area and operates a sequencing laboratory in San Diego. In 2016, Helix partnered with the National Geographic Society to sequence DNA for the Genographic Project. In 2018, Helix partnered with the Desert Research Institute and Renown Institute of Health Innovation in support of the Healthy Nevada project, which offers free access to genomic sequencing to 40,000 residents of northern Nevada for health research. Sequencing methodology Helix uses NGS to sequence a proprietary assay called Exome+, a version of Exome sequencing which according to the company provides 100 times more data than was previously available. Exome+ incl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypervariable Region
A hypervariable region (HVR) is a location within a sequence where polymorphisms frequently occur. It is used in two contexts: * In the case of nucleic acids, an HVR is where base pairs frequently change. This can be due to a change in the number of repeats (which is seen in eukaryotic nuclear DNA) or simply low selective pressure allowing a great number of substitutions and indels (as in the case of mitochondrial DNA D-loop and 16S rRNA). * In the case of antibodies, an HVR is where most of the differences among antibodies occur. This region is also called the complementarity-determining region. Because there already is a separate article for the antibody region, this article will focus on the nucleic acid case. Mitochondrial There are two mitochondrial hypervariable regions used in human mitochondrial genealogical DNA testing. HVR1 is considered a "low resolution" region and HVR2 is considered a "high resolution" region. Getting HVR1 and HVR2 DNA tests can help determine one ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
