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FYVE, RhoGEF And PH Domain Containing
FYVE, RhoGEF and PH domain containing (FGD) is a gene family consisting of: * FGD1 FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) also known as faciogenital dysplasia 1 protein (FGDY), zinc finger FYVE domain-containing protein 3 (ZFYVE3), or Rho/Rac guanine nucleotide exchange factor FGD1 (Rho/Rac GEF) is a protein th ... * FGD2 * FGD3 * FGD4 Type 1 is associated with Aarskog-Scott syndrome. See also * Guanine nucleotide exchange factor References External links * * Gene families {{GTP-binding protein regulators ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FGD1
FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) also known as faciogenital dysplasia 1 protein (FGDY), zinc finger FYVE domain-containing protein 3 (ZFYVE3), or Rho/Rac guanine nucleotide exchange factor FGD1 (Rho/Rac GEF) is a protein that in humans is encoded by the ''FGD1'' gene that lies on the X chromosome. Orthologs of the ''FGD1'' gene are found in dog, cow, mouse, rat, and zebrafish, and also budding yeast and ''C. elegans ''Caenorhabditis elegans'' () is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus. The name is a blend of the Greek ''caeno-'' (recent), ''rhabditis'' ( ...''. It is a member of the FYVE, RhoGEF and PH domain containing family. FGD1 is a guanine-nucleotide exchange factor (GEF) that can activate the Rho GTPase Cdc42. It localizes preferentially to the trans-Golgi network (TGN) of mammalian cells and regulates, for example, the secretory transpo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FGD2
FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the ''FGD2'' gene. It is a member of the FYVE, RhoGEF and PH domain containing FYVE, RhoGEF and PH domain containing (FGD) is a gene family consisting of: * FGD1 FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) also known as faciogenital dysplasia 1 protein (FGDY), zinc finger FYVE domain-containing protein 3 (ZFYVE3 ... family. References Further reading * * * * * * * * * * * {{gene-6-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FGD3
FYVE, RhoGEF and PH domain-containing protein 3 is a protein that in humans is encoded by the ''FGD3'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b .... References Further reading * * * * * * * * * External links PDBe-KB provides an overview of all the structure information available in the PDB for Human FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) {{gene-9-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FGD4
FYVE, RhoGEF and PH domain-containing protein 4 is a protein that in humans is encoded by the ''FGD4'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b .... References Further reading * * * * * * * * External links GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 4 {{gene-12-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guanine Nucleotide Exchange Factor
Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity. Some GEFs can activate multiple GTPases while others are specific to a single GTPase. Function Guanine nucleotide exchange factors (GEFs) are proteins or protein domains involved in the activation of small GTPases. Small GTPases act as molecular switches in intracellular signaling pathways and have many downstream targets. The most well-known GTPases comprise the Ras superfamily and are involved in essential cell processes such as cell differentiation and proliferation, cytoskeletal organization, vesicle trafficking, and nuclear transport. GTPases are active when bound to GTP and inactive when bound to GDP, allowing their activity to be regulated by GEFs and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
