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Eomes
Eomesodermin also known as T-box brain protein 2 (Tbr2) is a protein that in humans is encoded by the ''EOMES'' gene. The Eomesodermin/Tbr2 gene, ''EOMES'', encodes a member of a Conserved sequence, conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors, which control gene expression, involved in the regulation of developmental processes. Eomesodermin/Tbr2 itself controls regulation of Neural stem cell, radial glia, as well as other related cells. Eomesodermin/Tbr2 has also been found to have a role in Immune system, immune response, and there exists some loose evidence for its connections in other systems. Nervous system development Neurogenesis Eomesodermin/Tbr2 is expressed highly in the intermediate progenitor stage of the developing neuron. Neurons, the primary functional cells of the brain, are developed from Radial glial cell, radial glia cells. This process of cells developing into other types of cells ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TBR1
T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. It is encoded by the ''TBR1'' gene. This gene is also known by several other names: ''T-Brain 1'', ''TBR-1'', ''TES-56'', and ''MGC141978''. TBR1 is a member of the TBR1 subfamily of T-box family transcription factors, which share a common DNA-binding domain. Other members of the TBR1 subfamily include Eomesodermin, EOMES and TBX21. TBR1 is involved in the Cellular differentiation, differentiation and migration of neurons and is required for normal brain development. TBR1 interacts with various genes and proteins in order to regulate Cerebral cortex, cortical development, specifically within layer VI of the developing six-layered human cortex. Studies show that TBR1 may play a role in major neurological diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and autism spectrum disorder (ASD). Discovery TBR1 was identified in 1995 by the Nina Ireland Laboratory of Develo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
