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Endorestiform Nucleus
Endorestiform nucleus is a nucleus present within the inferior cerebellar peduncle of human brains. It was discovered by George Paxinos and his team at Neuroscience Research Australia (NeuRA). Paxinos had suspected the existence of the endorestiform nucleus for approximately 30 years. However, it was not until 2018 that he has been able to confirm its presence due to advances in staining and imaging techniques. The region is not present in rhesus monkeys and may be unique to humans. Etymology The name ''endorestiform'' is derived from the fact that the nucleus is present within (''endo'') the inferior cerebellar peduncle ( ''restiform'' body). Function Given that the endorestiform nucleus is located in the inferior cerebellar peduncle, it is thought that it might be involved in fine motor control. According to George Paxinos, its discovery might help researchers find cures for disorders such as Parkinson's disease and motor neuron disease Amyotrophic lateral sclerosis (AL ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleus (neuroanatomy)
In neuroanatomy, a nucleus (plural form: nuclei) is a cluster of neurons in the central nervous system, located deep within the cerebral hemispheres and brainstem. The neurons in one nucleus usually have roughly similar connections and functions. Nuclei are connected to other nuclei by tracts, the bundles (fascicles) of axons (nerve fibers) extending from the cell bodies. A nucleus is one of the two most common forms of nerve cell organization, the other being layered structures such as the cerebral cortex or cerebellar cortex. In anatomical sections, a nucleus shows up as a region of gray matter, often bordered by white matter. The vertebrate brain contains hundreds of distinguishable nuclei, varying widely in shape and size. A nucleus may itself have a complex internal structure, with multiple types of neurons arranged in clumps (subnuclei) or layers. The term "nucleus" is in some cases used rather loosely, to mean simply an identifiably distinct group of neurons, even if th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inferior Cerebellar Peduncle
The upper part of the posterior district of the medulla oblongata is occupied by the inferior cerebellar peduncle, a thick rope-like strand situated between the lower part of the fourth ventricle and the roots of the glossopharyngeal and vagus nerves. Each cerebellar inferior peduncle connects the spinal cord and medulla oblongata with the cerebellum, and comprises the juxtarestiform body and restiform body. Important fibers running through the inferior cerebellar peduncle include the dorsal spinocerebellar tract and axons from the inferior olivary nucleus, among others. Function The inferior cerebellar peduncle carries many types of input and output fibers that are mainly concerned with integrating proprioceptive sensory input with motor vestibular functions such as balance and posture maintenance. It consists of the following fiber tracts entering cerebellum: * Posterior spinocerebellar tract: unconscious proprioceptive information from the lower part of trunk and lower lim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Brains
The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head. The cerebrum, the largest part of the human brain, consists of two cerebral hemispheres. Each hemisphere has an inner core composed of white matter, and an outer surface – the cerebral cortex – composed of grey matter. The cortex has an outer layer, the neocortex, and an inner allocortex. The neocortex is made up of six neuronal layers, while the allocortex has three or four. Each hemisphere is conventionally divided into four lobes – the frontal, temporal, parietal, and occi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George Paxinos
George Paxinos AO DSc FASSA FAA FRSN FAHMS ( el, Γιώργος Παξινός, born 6 December 1944) is a Greek Australian neuroscientist, born in Ithaca, Greece. He completed his BA in psychology at the University of California at Berkeley and his PhD at McGill University in Montreal, Canada. After a postdoctoral year at Yale University, he moved to the School of Psychology of the University of New South Wales in Sydney, Australia. He is currently an NHMRC Senior Principal Research Fellow at Neuroscience Research Australia and Scientia Professor of Medical Sciences at the University of New South Wales. He is a fellow of the Australian Academy of Science, the Australian Academy of Social Sciences in Australia, and the Australian Academy of Health and Medical Sciences. He was also awarded a Distinguished Fellow of the Royal Society of New South Wales in 2019. Paxinos is a corresponding member of the Academy of Athens, and the only Australian with this award. Person ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroscience Research Australia
Neuroscience Research Australia (or NeuRA) is an independent medical research institute based in Sydney, Australia. Previously called the Prince of Wales Medical Research Institute, the institute relaunched as Neuroscience Research Australia on 1 June 2010. NeuRA is accredited by the National Health and Medical Research Council. Neuroscience Research Australia is made up of approximately 260 researchers specialising in research on the brain and nervous system in health and disease. The current executive director is Professor Peter R Schofield. Research activity NeuRA’s research activity is organised into five themes: * Ageing and neurodegeneration: Alzheimer's disease, frontotemporal dementia and other types of dementia, Parkinson's disease, motor neuron disease, ageing research in indigenous populations, stroke rehabilitation * Brain function and imaging: brain mapping for research and clinical use, on-site MRI scanning, autism * Neural injury: spinal cord injury, ass ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rhesus Monkey
The rhesus macaque (''Macaca mulatta''), colloquially rhesus monkey, is a species of Old World monkey. There are between six and nine recognised subspecies that are split between two groups, the Chinese-derived and the Indian-derived. Generally brown or grey in colour, it is in length with a tail and weighs . It is native to South, Central, and Southeast Asia and has the widest geographic range of all non-human primates, occupying a great diversity of altitudes and a great variety of habitats, from grasslands to arid and forested areas, but also close to human settlements. Feral colonies are found in the United States, thought to be either released by humans or escapees after hurricanes destroyed zoo and wildlife park facilities. The rhesus macaque is diurnal, arboreal, and terrestrial. It is mostly herbivorous, mainly eating fruit, but will also consume seeds, roots, buds, bark, and cereals. Studies show almost 100 different plant species in its diet. Rhesus macaques are gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Motor Control
Motor control is the regulation of movement in organisms that possess a nervous system. Motor control includes reflexes as well as directed movement. To control movement, the nervous system must integrate multimodal sensory information (both from the external world as well as proprioception Proprioception ( ), also referred to as kinaesthesia (or kinesthesia), is the sense of self-movement, force, and body position. It is sometimes described as the "sixth sense". Proprioception is mediated by proprioceptors, mechanosensory neurons ...) and elicit the necessary signals to recruit muscles to carry out a goal. This pathway spans many disciplines, including multisensory integration, signal processing, Motor coordination, coordination, biomechanics, and cognition, and the computational challenges are often discussed under the term sensorimotor control. Successful motor control is crucial to interacting with the world to carry out goals as well as for posture, balance, and stabil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkinson's Disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms become more common. The most obvious early symptoms are tremor, rigidity, slowness of movement, and difficulty with walking. Cognitive and behavioral problems may also occur with Depression (mood), depression, anxiety, and apathy occurring in many people with PD. Parkinson's disease dementia becomes common in the advanced stages of the disease. Those with Parkinson's can also have problems with their sleep and sensory systems. The motor symptoms of the disease result from the death of cells in the substantia nigra, a region of the midbrain, leading to a dopamine deficit. The cause of this cell death is poorly understood, but involves the build-up of protein, misfolded proteins into Lewy bodies in the neurons. Collectively, the main motor sym ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Motor Neuron Disease
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig's disease, is a neurodegenerative disease that results in the progressive loss of motor neurons that control voluntary muscles. ALS is the most common type of motor neuron diseases. Early symptoms of ALS include stiff muscles, muscle twitches, and gradual increasing weakness and muscle wasting. ''Limb-onset ALS'' begins with weakness in the arms or legs, while ''bulbar-onset ALS'' begins with difficulty speaking or swallowing. Half of the people with ALS develop at least mild difficulties with thinking and behavior, and about 15% develop frontotemporal dementia. Most people experience pain. The affected muscles are responsible for chewing food, speaking, and walking. Motor neuron loss continues until the ability to eat, speak, move, and finally the ability to breathe is lost. ALS eventually causes paralysis and early death, usually from respiratory failure. Most cases of ALS (abou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rosehip Neuron
Rosehip neurons are inhibitory GABAergic neurons present in the first layer (the molecular layer) of the human cerebral cortex. They make up about 10-15% of all inhibitory neurons in Layer 1. Neurons of this type (having "large ‘rosehip’-like axonal boutons and compact arborization") exist in humans, but have not been reported in rodents. Rosehip neurons are named after the rose hip fruit due to the axon terminal's resemblance to their berries. These rosehip cells show an immunohistochemical profile (GAD1+ CCK+, CNR1– SST–CALB2– PVALB–) matching a single transcriptomically defined cell type whose specific molecular marker signature is not seen in mouse cortex. Rosehip cells in layer 1 make homotypic gap junctions, predominantly target apical dendritic shafts of layer 3 pyramidal neurons, and inhibit backpropagating pyramidal action potentials in microdomains of the dendritic tuft. These cells are therefore positioned for potent local control of distal dendritic comp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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