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Dorothy M. Needham
Dorothy Mary Moyle Needham FRS (22 September 1896 – 22 December 1987) was an English biochemist known for her work on the biochemistry of muscle. She was married to biochemist Joseph Needham. Early life and education Dorothy Mary Moyle was born in London, to patent clerk John Thomas Moyle and his wife, Ellen Daves. She attended Claremont College, Stockport, an institution run by her aunt, Agnes Daves, and St Hilary's School, Alderley Edge, before entering Girton College, Cambridge. At Girton she became interested in chemistry, and biochemistry in particular after attending the lectures of Frederick Gowland Hopkins. After completing undergraduate studies in 1919, in which she obtained a 3rd Class Honours, she was offered a research position with Hopkins—one of the few scientific leaders at Cambridge at the time who offered research opportunities for women—at the Sir William Dunn Institute of Biochemistry, Cambridge, She earned a Master of Arts in 1923, and a PhD in 1930 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Succinic Acid
Succinic acid () is a dicarboxylic acid with the chemical formula (CH2)2(CO2H)2. In living organisms, succinic acid takes the form of an anion, succinate, which has multiple biological roles as a metabolic intermediate being converted into fumarate by the enzyme succinate dehydrogenase in complex 2 of the electron transport chain which is involved in making ATP, and as a signaling molecule reflecting the cellular metabolic state. Succinate is generated in mitochondria via the tricarboxylic acid (TCA) cycle. Succinate can exit the mitochondrial matrix and function in the cytoplasm as well as the extracellular space, changing gene expression patterns, modulating epigenetic landscape or demonstrating hormone-like signaling. As such, succinate links cellular metabolism, especially ATP formation, to the regulation of cellular function. Dysregulation of succinate synthesis, and therefore ATP synthesis, happens in some genetic mitochondrial diseases, such as Leigh syndrome, and Me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gonville And Caius College, Cambridge
Gonville and Caius College, commonly known as Caius ( ), is a constituent college of the University of Cambridge in Cambridge, England. Founded in 1348 by Edmund Gonville, it is the fourth-oldest of the University of Cambridge's 31 colleges and one of the wealthiest. In 1557, it was refounded by John Caius, an alumnus and English physician. The college has been attended by many students who have gone on to significant accomplishment, including fifteen Nobel Prize winners, the second-largest number of any Oxbridge college. Several streets in the city, including Harvey Road, Glisson Road, and Gresham Road, are named after Gonville and Caius alumni. The college and its masters have been influential in the development of the university, including in the founding of other colleges, including Trinity Hall, Cambridge, Trinity Hall and Darwin College, Cambridge, Darwin College and providing land on Sidgwick Site on which the Faculty of Law, University of Cambridge, Faculty of Law was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lucy Cavendish College, Cambridge
Lucy Cavendish College is a Colleges of the University of Cambridge, constituent college of the University of Cambridge. The college was established in 1965 as a women's college and since 2021 has admitted both women and men. The college is named in honour of Lucy Cavendish (1841–1925), who campaigned for the reform of women's education. History The college was founded in 1965 by female academics of the University of Cambridge who believed that the university offered too few and too restricted opportunities for women as either students or academics. Its origins are traceable to the ''Society of Women Members of the Regent House who are not Fellows of Colleges'' (informally known as the Dining Group) which in the 1950s sought to provide the benefits of collegiality to its members who, being female, were not college fellows. At the time there were only two women's colleges in Cambridge, Girton College, Cambridge, Girton and Newnham College, Cambridge, Newnham, insufficient for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doctor Of Science
A Doctor of Science (; most commonly abbreviated DSc or ScD) is a science doctorate awarded in a number of countries throughout the world. Africa Algeria and Morocco In Algeria, Morocco, Libya and Tunisia, all universities accredited by the state award a "Doctorate" in all fields of science and humanities, equivalent to a PhD in the United Kingdom or United States. Some universities in these four North African countries award a "Doctorate of the State" in some fields of study and science. A "Doctorate of the State" is slightly higher in esteem than a regular doctorate, and is awarded after performing additional in-depth post-doctorate research or achievement. Asia Japan Similarly to in the US and most of Europe, Japanese universities offer both the PhD and the ScD as initial doctorates in science. India In India only a few prestigious universities offer ScD/DSc in science which is obtained in Graduate School after satisfactory evaluation of knowledge, research accomp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chongqing
ChongqingPostal Romanization, Previously romanized as Chungking ();. is a direct-administered municipality in Southwestern China. Chongqing is one of the four direct-administered municipalities under the State Council of the People's Republic of China, Central People's Government, along with Beijing, Shanghai, and Tianjin. It is the only directly administrated municipality located deep inland. The municipality covers a large geographical area roughly the size of Austria, which includes several disjunct urban areas in addition to Chongqing proper. Due to its classification, the municipality of Chongqing is the List of largest cities, largest city proper in the world by population, though Chongqing is not the most populous urban area. The municipality of Chongqing is the only Chinese city with a resident population of over 30 million; however, this number includes its large rural population. In 2020, Chongqing surpassed Shanghai as China's largest municipality by urban populati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mustard Gas
Mustard gas or sulfur mustard are names commonly used for the organosulfur compound, organosulfur chemical compound bis(2-chloroethyl) sulfide, which has the chemical structure S(CH2CH2Cl)2, as well as other Chemical species, species. In the wider sense, compounds with the substituents are known as ''sulfur mustards'' or ''nitrogen mustards'', respectively, where X = Cl or Br. Such compounds are potent alkylating agents, making mustard gas acutely and severely toxic. Mustard gas is a carcinogen. There is no preventative agent against mustard gas, with protection depending entirely on skin and airways protection, and no antidote exists for mustard poisoning. Also known as mustard agents, this family of compounds comprises infamous cytotoxicity, cytotoxins and blister agents with a long history of use as chemical weapons. The name ''mustard gas'' is technically incorrect; the substances, when Dispersion (chemistry), dispersed, are often not gases but a fine mist of liquid droplet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ministry Of Supply
The Ministry of Supply (MoS) was a department of the UK government formed on 1 August 1939 by the Ministry of Supply Act 1939 ( 2 & 3 Geo. 6. c. 38) to co-ordinate the supply of equipment to all three British armed forces, headed by the Minister of Supply. A separate ministry, however, was responsible for aircraft production, and the Admiralty retained responsibilities for supplying the Royal Navy.Hornby (1958) During the war years the MoS was based at Shell Mex House in The Strand, London. The Ministry of Supply also took over all army research establishments in 1939. The Ministry of Aircraft Production was abolished in 1946, and the MoS took over its responsibilities for aircraft, including the associated research establishments. In the same year, it also took on increased responsibilities for atomic weapons, including the H-bomb development programme. The Ministry of Supply was abolished in late 1959 and its responsibilities passed to the Ministry of Aviation, the War Of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malcolm Dixon (biochemist)
Malcolm Dixon (18 April 1899 – 7 December 1985) was a British biochemist. Education and early life Dixon was born in Cambridge, England, to Allick Page Dixon and Caroline Dewe Dixon (née Mathews). He was educated at home (having come down with tuberculosis aged 12) and at Emmanuel College, Cambridge, where he graduated with a BA in Natural Sciences in 1921 and was later an 1851 Exhibition Senior Student.) He was awarded his PhD at Cambridge in 1925, for research supervised by Frederick Gowland Hopkins. Research and career Dixon's research investigated the purification of enzymes and the enzyme kinetics of enzyme-catalyzed reactions. He studied the oxidation of glutathione and other thiols by molecular oxygen and measured the redox potential of the thiol-disulfide system, also establishing that the oxidation of glutathione was catalyzed by trace metals. He investigated xanthine oxidase, and thereby elucidated many aspects of the chemistry of dehydrogenases. He showed that the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ATPase
ATPases (, Adenosine 5'-TriPhosphatase, adenylpyrophosphatase, ATP monophosphatase, triphosphatase, ATP hydrolase, adenosine triphosphatase) are a class of enzymes that catalyze the decomposition of ATP into ADP and a free phosphate ion or the inverse reaction. This dephosphorylation reaction releases energy, which the enzyme (in most cases) harnesses to drive other chemical reactions that would not otherwise occur. This process is widely used in all known forms of life. Some such enzymes are integral membrane proteins (anchored within biological membranes), and move solutes across the membrane, typically against their concentration gradient. These are called transmembrane ATPases. Functions Transmembrane ATPases import metabolites necessary for cell metabolism and export toxins, wastes, and solutes that can hinder cellular processes. An important example is the sodium-potassium pump (Na+/K+ATPase) that maintains the cell membrane potential. Another example is the h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myosin
Myosins () are a Protein family, family of motor proteins (though most often protein complexes) best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes. They are adenosine triphosphate, ATP-dependent and responsible for actin-based motility. The first myosin (M2) to be discovered was in 1864 by Wilhelm Kühne. Kühne had extracted a viscous protein from skeletal muscle that he held responsible for keeping the tension state in muscle. He called this protein ''myosin''. The term has been extended to include a group of similar ATPases found in the cell (biology), cells of both striated muscle tissue and smooth muscle tissue. Following the discovery in 1973 of enzymes with myosin-like function in ''Acanthamoeba, Acanthamoeba castellanii'', a global range of divergent myosin genes have been discovered throughout the realm of eukaryotes. Although myosin was originally thought to be restricted to muscle cells (hence ''wikt:myo-#Pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anaerobic Respiration
Anaerobic respiration is respiration using electron acceptors other than molecular oxygen (O2). Although oxygen is not the final electron acceptor, the process still uses a respiratory electron transport chain. In aerobic organisms undergoing respiration, electrons are shuttled to an electron transport chain, and the final electron acceptor is oxygen. Molecular oxygen is an excellent electron acceptor. Anaerobes instead use less-oxidizing substances such as nitrate (), fumarate (), sulfate (), or elemental sulfur (S). These terminal electron acceptors have smaller reduction potentials than O2. Less energy per oxidized molecule is released. Therefore, anaerobic respiration is less efficient than aerobic. As compared with fermentation Anaerobic cellular respiration and fermentation generate ATP in very different ways, and the terms should not be treated as synonyms. Cellular respiration (both aerobic and anaerobic) uses highly reduced chemical compounds such as NADH and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
