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David Colquhoun
David Colquhoun (born 19 July 1936) is a British pharmacologist at University College London (UCL). He has contributed to the general theory of receptor and synaptic mechanisms, and in particular the theory and practice of single ion channel function. He held the A.J. Clark chair of Pharmacology at UCL from 1985 to 2004, and was the Hon. Director of the Wellcome Laboratory for Molecular Pharmacology. He was elected a Fellow of the Royal Society (FRS) in 1985 and an honorary fellow of UCL in 2004. Colquhoun runs the website ''DC's Improbable Science'', which is critical of pseudoscience, particularly alternative medicine, and managerialism. Early life and education Colquhoun was born on 19 July 1936 in Birkenhead, UK. He was educated at Birkenhead School and Liverpool Technical College. After working unhappily as an apprentice pharmacist, he was motivated to go into research. He obtained a BSc from the University of Leeds with a specialisation in pharmacology, and we ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxford University Press
Oxford University Press (OUP) is the publishing house of the University of Oxford. It is the largest university press in the world. Its first book was printed in Oxford in 1478, with the Press officially granted the legal right to print books by decree in 1586. It is the second-oldest university press after Cambridge University Press, which was founded in 1534. It is a department of the University of Oxford. It is governed by a group of 15 academics, the Delegates of the Press, appointed by the Vice Chancellor, vice-chancellor of the University of Oxford. The Delegates of the Press are led by the Secretary to the Delegates, who serves as OUP's chief executive and as its major representative on other university bodies. Oxford University Press has had a similar governance structure since the 17th century. The press is located on Walton Street, Oxford, Walton Street, Oxford, opposite Somerville College, Oxford, Somerville College, in the inner suburb of Jericho, Oxford, Jericho. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, recognising excellence in science, supporting outstanding science, providing scientific advice for policy, education and public engagement and fostering international and global co-operation. Founded on 28 November 1660, it was granted a royal charter by Charles II of England, King Charles II and is the oldest continuously existing scientific academy in the world. The society is governed by its Council, which is chaired by the society's president, according to a set of statutes and standing orders. The members of Council and the president are elected from and by its Fellows, the basic members of the society, who are themselves elected by existing Fellows. , there are about 1,700 fellows, allowed to use the postnominal title FRS (Fellow ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bert Sakmann
Bert Sakmann (; born 12 June 1942) is a German cell physiologist. He shared the Nobel Prize in Physiology or Medicine with Erwin Neher in 1991 for their work on "the function of single ion channels in cells," and the invention of the patch clamp. Bert Sakmann was Professor at Heidelberg University and is an Emeritus Scientific Member of the Max Planck Institute for Medical Research in Heidelberg, Germany. Since 2008 he leads an emeritus research group at the Max Planck Institute of Neurobiology. Life and career Sakmann was born in Stuttgart, the son of Annemarie (née Schaefer), a physical therapist, and Bertold Sakmann, a theater director. Sakmann enrolled in Volksschule in Lindau, and completed the Wagenburg gymnasium in Stuttgart in 1961. He studied medicine from 1967 onwards in Tübingen, Freiburg, Berlin, Paris and Munich. After completing his medical exams at Ludwig-Maximilians University in Munich, he became a medical assistant in 1968 at Munich University, while als ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erwin Neher
Erwin Neher (; ; born 20 March 1944) is a German biophysicist, specializing in the field of cell physiology. For significant contribution in the field, in 1991 he was awarded, along with Bert Sakmann, the Nobel Prize in Physiology or Medicine for "their discoveries concerning the function of single ion channels in cells". Early life and education Neher was born in Landsberg am Lech, Upper Bavaria, the son of Elisabeth (née Pfeiffer), a teacher, and Franz Xaver Neher, an executive at a dairy company. He studied physics at the Technical University of Munich from 1963 to 1966. In 1966, he was awarded a Fulbright Scholarship to study in the US. He spent a year at the University of Wisconsin–Madison, and earned a master's degree in biophysics. While at the Charles Stevens Laboratory at Yale University for post-doctoral work he met fellow scientist Eva-Maria Neher, whom he married in 1978 and subsequently the couple had five children – Richard, Benjamin, Carola, Sigmund, and Ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Patch Clamp
The patch clamp technique is a laboratory technique in electrophysiology used to study ionic currents in individual Cell isolation, isolated living cells, tissue sections, or patches of cell membrane. The technique is especially useful in the study of excitable cells such as neurons, cardiomyocytes, muscle fibers, and pancreas, pancreatic beta cells, and can also be applied to the study of bacterial ion channels in specially prepared giant spheroplasts. Patch clamping can be performed using the voltage clamp technique. In this case, the voltage across the cell membrane is controlled by the experimenter and the resulting currents are recorded. Alternatively, the Electrophysiology, current clamp technique can be used. In this case, the current passing across the membrane is controlled by the experimenter and the resulting changes in voltage are recorded, generally in the form of action potentials. Erwin Neher and Bert Sakmann developed the patch clamp in the late 1970s and earl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synapse
In the nervous system, a synapse is a structure that allows a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or a target effector cell. Synapses can be classified as either chemical or electrical, depending on the mechanism of signal transmission between neurons. In the case of electrical synapses, neurons are coupled bidirectionally with each other through gap junctions and have a connected cytoplasmic milieu. These types of synapses are known to produce synchronous network activity in the brain, but can also result in complicated, chaotic network level dynamics. Therefore, signal directionality cannot always be defined across electrical synapses. Chemical synapses, on the other hand, communicate through neurotransmitters released from the presynaptic neuron into the synaptic cleft. Upon release, these neurotransmitters bind to specific receptors on the postsynaptic membrane, inducing an electrical or chemical response in the target neuron ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Department Of Pharmacology At University College London, 1905 – 2007
The Department of Pharmacology at the University College London, the first of its kind in England, was founded in 1905 and remained in existence until 2007. Early history University College London (UCL) was founded in 1826. It was born in the ferment of radical London in the 1820s and 1830s and was heavily influenced by the Scottish and French Enlightenments. UCL was part of the radical opposition to the hegemony of Oxford and Cambridge. In medicine, UCL was a force in combatting the conservative and religious monopoly of the Royal Colleges of Physicians and Surgeons Although Edinburgh University was well ahead at the time, UCL had a professor of Materia Medica and Pharmacy, A.T.Thomson, from the start. Later this was renamed as the chair of Materia Medica and Therapeutics. Its best known holder was Sydney Ringer (1878–87), who worked on the isolated beating heart and is renowned for his eponymous salt solution which he designed to maximise the viability of isolated hear ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malcolm Grant
Sir Malcolm John Grant, , (born 29 November 1947) is a barrister, academic lawyer, and former law professor. Born and educated in New Zealand, he was the ninth President and Provost of University College London – the head as well as principal academic and administrative officer of the university – for over a decade from 2003 until 2013. He then served for 7 years as chairman of NHS England (previously known as the NHS Commissioning Board). He has published extensively in planning and environmental law, and local government law, including serving for 23 years (1981–2004) as the editor of the 8 loose leaf volume ''Encyclopaedia of Planning Law and Practice'' of which he remains a consultant editor. From 2015 to 2022, he was the Chancellor of the University of York. Early life, education and previous work Grant was born and raised in Oamaru, New Zealand. He attended the state-run Waitaki Boys' High School and was organist at St Luke's Church. He went on to study at the U ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Walter Perry
Walter Laing MacDonald Perry, Baron Perry of Walton (16 June 1921 – 17 July 2003) was a Scottish academic. He was the first Vice Chancellor of the Open University. Life Perry was born in Dundee, son of Flora and Fletcher Perry, and educated at Ayr Academy and the High School of Dundee. He studied medicine at the University of St Andrews, graduating with an MB ChB in 1943, MD in 1948 and a DSc in 1958. Between 1944 and 1946 he worked as a Medical Officer in Nigeria. He later worked as a scientist for institutions like the Medical Research Council. In particular he became an expert on polio. He had a reputation for following the scientific method rigorously. He developed his career at the University of Edinburgh as Professor of Pharmacology, later Dean of Medicine and Vice Principal. In 1959 he was elected a member of the Harveian Society of Edinburgh. In 1969 he became Vice Chancellor of the Open University and made that university into an effective institution proving th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunoglobulin
An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the immunoglobulin superfamily which is used by the immune system to identify and neutralize antigens such as pathogenic bacteria, bacteria and viruses, including those that cause disease. Each individual antibody recognizes one or more specific antigens, and antigens of virtually any size and chemical composition can be recognized. Antigen literally means "antibody generator", as it is the presence of an antigen that drives the formation of an antigen-specific antibody. Each of the branching chains comprising the "Y" of an antibody contains a paratope that specifically binds to one particular epitope on an antigen, allowing the two molecules to bind together with precision. Using this mechanism, antibodies can effectively "tag" the antigen (or a microbe or an infected cell bearing such an antigen) for attack by cells of the immune system, or can neutralize it directly (for example, by blocking a p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liverpool Technical College
The College of Technology and Museum Extension on Byrom Street in Liverpool, England, was built between 1896 and 1909, the architect was Edward William Mountford. The building was constructed to provide a new College of Technology and an extension to the museum. The college occupied the lower levels and the museum the upper levels. Bomb damage led to some reconstruction work in the 1960s. The building was Grade II* listed in 1966. The lower levels were taken over by Liverpool Polytechnic and its successor Liverpool John Moores University. Initially, they held the engineering department but were subsequently split between the Sports Science and Computing Services departments, being home to the University's DEC and VAX computers. More recently, during the transformation of Liverpool Museum into World Museum Liverpool, the museum acquired the remainder of the building which now houses its research department. See also * Architecture of Liverpool The architecture of Liverp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Birkenhead School
Birkenhead School is a Private schools in the United Kingdom, private, academically-selective, co-educational day school located in Oxton, Merseyside, Oxton, Wirral Peninsula, Wirral, in North West England. The school offers educational opportunities for girls and boys from three months to eighteen years of age. Birkenhead School is a member of the Headmasters' and Headmistresses' Conference, which is a UK-based association of leading independent schools. Overview Birkenhead School comprises: *Nursery (for children aged 3 months to 3 years) *Pre-Prep (for children aged 3 to 4 years) *Prep (Reception to Year 6) *Seniors (Years 7 to 11) *Sixth Form (Lower Sixth and Upper Sixth) Birkenhead School is funded by fees. Bursary, Bursaries are available to help students take up or retain a place at the school where their parents or guardian cannot pay full fees. Bursaries are means-tested and may cover up to 100% of the full fee. Bursaries typically support between 70 and 80 pupils ea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
