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César Milstein
César Milstein, CH, FRS (8 October 1927 – 24 March 2002) was an Argentine biochemist in the field of antibody research. Milstein shared the Nobel Prize in Physiology or Medicine in 1984 with Niels Kaj Jerne and Georges J. F. Köhler for developing the hybridoma technique for the production of monoclonal antibodies. Biography Milstein was born in Bahía Blanca, Argentina. His parents were Máxima (Vanarks) and Lázaro Milstein, a Jewish Ukrainian immigrant. He graduated from the University of Buenos Aires and obtained a PhD under Professor Stopani (Professor of Biochemistry). Later he became a member of the Medical Research Council Laboratory of Molecular Biology, Cambridge, England; he acquired British citizenship and had dual British-Argentinian nationality. In 1956, he received an award from the Sociedad Argentina de Investigation eon Bio Quimica (SAIB) for his work on enzyme kinetics with the enzyme aldehyde dehydrogenase. In 1958, funded by the British Council, he j ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bahía Blanca
Bahía Blanca (; English: ''White Bay''), colloquially referred to by its own local inhabitants as simply Bahía, is a city in the Buenos Aires Province, Buenos Aires province of Argentina, centered on the northwestern end of the eponymous Blanca Bay of the Argentine Sea. It is 4th largest city in the province, and the 16th largest in the country by metropolitan population. It is the seat of government of the Bahía Blanca Partido, with 336,574 inhabitants according to the . Bahía Blanca is the principal city in the Greater Bahía Blanca metropolitan area. The city has an important seaport with a depth of , kept constant upstream almost all along the length of the bay, where the Napostá Stream drains. ''Bahía Blanca'' means "White Bay". The name is due to the color of the salt covering the local soil surrounding the shores. The bay (which is an estuary) was seen by Ferdinand Magellan during his first circumnavigation of the world on the order of Charles I of Spain in 1520, lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Order Of The Companions Of Honour
The Order of the Companions of Honour is an Order (distinction), order of the Commonwealth realms. It was founded on 4 June 1917 by King George V as a reward for outstanding achievements. It was founded on the same date as the Order of the British Empire. The order was originally intended to be conferred upon a limited number of persons for whom this special distinction seemed to be the most appropriate form of recognition, constituting an honour dissociated from either the acceptance of title or the classification of merit. It is now described as being "awarded for having a major contribution to the arts, science, medicine, or government lasting over a long period of time". The first recipients of the order were all decorated for "services in connection with the First World War, war" and were listed in ''The London Gazette''. Composition The order consists of the monarch of the Commonwealth realms, who is the Sovereign of the Order of the Companions of Honour, and a maximum o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Lancet
''The Lancet'' is a weekly peer-reviewed general medical journal, founded in England in 1823. It is one of the world's highest-impact academic journals and also one of the oldest medical journals still in publication. The journal publishes original research articles, review articles ("seminars" and "reviews"), editorials, book reviews, correspondence, as well as news features and case reports. ''The Lancet'' has been owned by Elsevier since 1991, and its editor-in-chief since 1995 has been Richard Horton. The journal has editorial offices in London, New York City, and Beijing. History ''The Lancet'' was founded in 1823 by Thomas Wakley, an English surgeon who named it after the surgical instrument called a lancet (scalpel). According to BBC, the journal was initially considered to be radical following its founding. Members of the Wakley family retained editorship of the journal until 1908. In 1921, ''The Lancet'' was acquired by Hodder & Stoughton. Elsevier acquire ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hybridoma
Hybridoma technology is a method for producing large quantities of monoclonal antibodies by fusing antibody producing B cells with myeloma cells (cancerous B cells). This creates hybrid cells, ''hybridomas,'' that produce the antibody from their parent B cell whilst maintaining the properties of the parental myeloma cell line being immortal (endlessly reproducing) and having desirable properties for cell culture. The B cells to be used are generally gathered from animals who have been immunized with an antigen against which an antibody targeting it is desired. After forming hybridomas any non-hybrid cells are killed before screening and monoclonalization to create hybridoma lines that are derived from one parental cell and thus producing the same antibody against the desired target. The production of monoclonal antibodies was invented by César Milstein and Georges J. F. Köhler in 1975. They shared the Nobel Prize of 1984 for Medicine and Physiology with Niels Kaj Jerne, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Georges J
Georges may refer to: Places *Georges River The Georges River, also known as Tucoerah River, is an intermediate tide-dominated Ria, drowned valley estuary, that is located in Sydney, Australia. The Georges River is located south and south-west from the Sydney central business district, w ..., New South Wales, Australia * Georges Quay (Dublin) * Georges Township, Fayette County, Pennsylvania Other uses * Georges (name) * ''Georges'' (novel), a novel by Alexandre Dumas * "Georges" (song), a 1977 song originally recorded by Pat Simon and covered by Sylvie Vartan * Georges (store), a department store in Melbourne, Australia from 1880 to 1995 * Georges (''Green Card'' character) People with the surname * Eugenia Georges, American anthropologist * Karl Ernst Georges (1806–1895), German classical philologist and lexicographer, known for his edition of Latin-German dictionaries. * Mary Ngwanda Georges, Congo-born American politician See also * École secondaire Georges-P.-Vanier, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Niels Kaj Jerne
Niels Kaj Jerne, FRS (23 December 1911 – 7 October 1994) was a Danish immunologist. He shared the Nobel Prize in Physiology or Medicine in 1984 with Georges J. F. Köhler and César Milstein "for theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies". Jerne is known for three significant ideas. Firstly, instead of the body producing antibodies in response to an antigen, Jerne postulated that the immune system already has the specific antibodies it needs to fight antigens. Secondly, it was known that the immune system learns to be tolerant to the individual's own self. Jerne postulated that this learning takes place in the thymus. Thirdly, it was known that T cells and B cells communicate with each other. Jerne's network theory proposed that the active sites of antibodies are attracted to both specific antigens ( idiotypes) and to other antibodies that bind to the same ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features Peer review, peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2022 ''Journal Citation Reports'' (with an ascribed impact factor of 50.5), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in the autumn of 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander MacMillan (publisher), Alexander MacMillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the j ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Current Biology
''Current Biology'' is a biweekly peer-reviewed scientific journal that covers all areas of biology, especially molecular biology, cell biology, genetics, neurobiology, ecology, and evolutionary biology. The journal includes research articles, various types of review articles, as well as an editorial magazine section. The journal was established in 1991 by the Current Science group, was acquired by Elsevier in 1998, and has since 2001 been part of Cell Press, a subdivision of Elsevier. According to '' Journal Citation Reports'', the journal has a 2020 impact factor of 10.834. It was categorized as a "high impact journal" by the Superfund Research Program. References External links * Biology journals English-language journals Cell Press academic journals Academic journals established in 1991 Biweekly journals {{biology-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science (journal)
''Science'' is the peer review, peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature (journal), Nature'' cover the full range of List of academ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Immunology
''Nature Immunology'' is a monthly peer-reviewed scientific journal covering immunology. It was established in 2000, as an expansion of the ''Nature'' family of journals. The editor-in-chief is Jamie D. K. Wilson. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a type of journal ranking. Journals with higher impact factor values are considered more prestigious or important within their field. The Impact Factor of a journa ... of 31.250, ranking it 4th out of 161 journals in the category "Immunology". References External links * Academic journals established in 2000 Immunology journals Nature Research academic journals Monthly journals English-language journals {{immunology-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibody
An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the immunoglobulin superfamily which is used by the immune system to identify and neutralize antigens such as pathogenic bacteria, bacteria and viruses, including those that cause disease. Each individual antibody recognizes one or more specific antigens, and antigens of virtually any size and chemical composition can be recognized. Antigen literally means "antibody generator", as it is the presence of an antigen that drives the formation of an antigen-specific antibody. Each of the branching chains comprising the "Y" of an antibody contains a paratope that specifically binds to one particular epitope on an antigen, allowing the two molecules to bind together with precision. Using this mechanism, antibodies can effectively "tag" the antigen (or a microbe or an infected cell bearing such an antigen) for attack by cells of the immune system, or can neutralize it directly (for example, by blocking a p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biochemist
Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of "biological chemist." Biochemists also research how certain chemical reactions happen in cells and Tissue (biology), tissues and observe and record the effects of Product (chemistry), products in food additives and Medication, medicines. Biochemist researchers focus on playing and constructing research experiments, mainly for developing new products, updating existing products and analyzing said products. It is also the responsibility of a biochemist to present their research findings and create Grant writing, grant proposals to obtain Funding of science, funds for future research. Biochemists study aspects of the immune system, the expressions of genes, isolating, analyzing, and synthesizing different products, mutations that lead to ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
