Cucurbitacin J 2-O-β-glucopyranoside
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Cucurbitacin J 2-O-β-glucopyranoside
Cucurbitacins are a class of biochemical compounds that some plants – notably members of the pumpkin and gourd family, Cucurbitaceae – produce and which function as a defense against herbivores. Cucurbitacins and their derivatives have also been found in many other plant families (including Brassicaceae, Scrophulariaceae, Begoniaceae, Elaeocarpaceae, Datiscaceae, Desfontainiaceae, Polemoniaceae, Primulaceae, Rubiaceae, Sterculiaceae, Rosaceae, and Thymelaeaceae), in some mushrooms (including ''Russula'' and ''Hebeloma'') and even in some marine mollusks. Cucurbitacins may be a taste deterrent in plants foraged by some animals and in some edible plants preferred by humans, such as cucumbers and zucchinis. In laboratory research, cucurbitacins have cytotoxic properties and are under study for their potential biological activity. Cucurbitacins are chemically classified as triterpenes, formally derived from cucurbitane, a triterpene hydrocarbon – specifically, from the uns ...
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Cucurbitane Grundstruktur Num
Cucurbitane is a tetracyclic chemical compound with formula . It is a polycyclic hydrocarbon, polycyclic hydrocarbon, specifically triterpene. It is also an isomer of lanostane (specifically 19(10→9β)-abeolanostane), from which it differs by the formal shift of a methyl group (carbon number 19) from the 10 to the 9β position in the standard steroid numbering scheme.Satish Kumar and Raj Kumar (1991), ''Dictionary of Biochemistry''. Anmol Publications, India The name is applied to two stereoisomers, distinguished by the prefixes 5α- and 5β-, which differ by the handedness of the bonds at a particular carbon atom (number 5 in the standard steroid numbering scheme). File:5alpha-cucurbitane.svg, 5α-Cucurbitane File:5beta-cucurbitane.svg, 5β-Cucurbitane Cucurbitane is the core chemical structure of a class of derivative (chemistry), derivatives known as cucurbitane-type triterpenoids or simply as cucurbitanes. Derivatives Natural compounds Compounds with the basic cucurbi ...
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Sterculiaceae
Sterculiaceae was a family of flowering plant based on the genus '' Sterculia''. Genera formerly included in Sterculiaceae are now placed in the family Malvaceae, in the subfamilies: Byttnerioideae, Dombeyoideae, Helicteroideae and Sterculioideae. As traditionally circumscribed the Sterculiaceae, Malvaceae, Bombacaceae, and Tiliaceae comprise the "core Malvales" of the Cronquist system and the close relationship among these families is generally recognized. Sterculiaceae may be separated from Malvaceae '' sensu stricto'' by the smooth surface of the pollen grains and the bilocular anthers. Numerous phylogenetic studies have revealed that Sterculiaceae, Tiliaceae and Bombacaceae as traditionally defined are cladistically polyphyletic. The APG and APG II systems unite Bombacaceae, Malvaceae ''sensu stricto'', Sterculiaceae and Tiliaceae into a more widely circumscribed Malvaceae, i.e., Malvaceae '' sensu lato''. In that view the taxa formerly classified in Sterculiaceae are ...
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Hydrocarbon
In organic chemistry, a hydrocarbon is an organic compound consisting entirely of hydrogen and carbon. Hydrocarbons are examples of group 14 hydrides. Hydrocarbons are generally colourless and Hydrophobe, hydrophobic; their odor is usually faint, and may be similar to that of gasoline or Naphtha, lighter fluid. They occur in a diverse range of molecular structures and phases: they can be gases (such as methane and propane), liquids (such as hexane and benzene), low melting solids (such as paraffin wax and naphthalene) or polymers (such as polyethylene and polystyrene). In the fossil fuel industries, ''hydrocarbon'' refers to naturally occurring petroleum, natural gas and coal, or their hydrocarbon derivatives and purified forms. Combustion of hydrocarbons is the main source of the world's energy. Petroleum is the dominant raw-material source for organic commodity chemicals such as solvents and polymers. Most anthropogenic (human-generated) emissions of greenhouse gases are eithe ...
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Cucurbitane
Cucurbitane is a tetracyclic chemical compound with formula . It is a polycyclic hydrocarbon, specifically triterpene. It is also an isomer of lanostane (specifically 19(10→9β)-abeolanostane), from which it differs by the formal shift of a methyl group (carbon number 19) from the 10 to the 9β position in the standard steroid numbering scheme.Satish Kumar and Raj Kumar (1991), ''Dictionary of Biochemistry''. Anmol Publications, India The name is applied to two stereoisomers, distinguished by the prefixes 5α- and 5β-, which differ by the handedness of the bonds at a particular carbon atom (number 5 in the standard steroid numbering scheme). File:5alpha-cucurbitane.svg, 5α-Cucurbitane File:5beta-cucurbitane.svg, 5β-Cucurbitane Cucurbitane is the core chemical structure of a class of derivatives known as cucurbitane-type triterpenoids or simply as cucurbitanes. Derivatives Natural compounds Compounds with the basic cucurbitane skeleton are found in many plants, an ...
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Triterpene
Triterpenes are a class of terpenes composed of six isoprene units with the molecular formula C30H48; they may also be thought of as consisting of three terpene units. Animals, plants and fungi all produce triterpenes, including squalene, the precursor to all steroids. Structures Triterpenes exist in a great variety of structures. Nearly 200 different skeletons have been identified. These skeletons may be broadly divided according to the number of rings present. In general pentacyclic structures (5 rings) tend to dominate. Squalene is biosynthesized through the head-to-head condensation of two farnesyl pyrophosphate units. This coupling converts a pair of C15 components into a C30 product. Squalene serves as precursor for the formation of many triterpenoids, including bacterial hopanoids and eukaryotic sterols. Triterpenoids By definition triterpenoids are triterpenes that possess heteroatoms, usually oxygen. The terms ''triterpene'' and ''triterpenoid'' often are used i ...
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Cytotoxic
Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are toxic metals, toxic chemicals, microbe neurotoxins, radiation particles and even specific neurotransmitters when the system is out of balance. Also some types of drugs, e.g alcohol, and some venom, e.g. from the puff adder (''Bitis arietans'') or brown recluse spider (''Loxosceles reclusa'') are toxic to cells. Cell physiology Treating cells with the cytotoxic compound can result in a variety of prognoses. The cells may undergo necrosis, in which they lose membrane integrity and die rapidly as a result of cell lysis. The cells can stop actively growing and dividing (a decrease in cell viability), or the cells can activate a genetic program of controlled cell death (apoptosis). Cells undergoing necrosis typically exhibit rapid swelling, lose membrane integrity, shut down metabolism, and release their contents into the environment. Cells that undergo rapid necrosis in vitro do not have sufficient t ...
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Basic Research
Basic research, also called pure research, fundamental research, basic science, or pure science, is a type of scientific research with the aim of improving scientific theories for better understanding and prediction of natural or other phenomena. In contrast, applied research uses scientific theories to develop technology or techniques, which can be used to intervene and ''alter'' natural or other phenomena. Though often driven simply by curiosity,"Curiosity creates cures: The value and impact of basic research
, National Institute of General Medical Sciences,

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Zucchini
Zucchini (; : ''zucchini'' or ''zucchinis''), courgette () or ''Cucurbita pepo'' is a summer squash, a Vine, vining herbaceous plant whose fruit are harvested when their immature seeds and Fruit anatomy#Epicarp, epicarp (rind) are still soft and edible. It is closely related, but not identical, to the Marrow (vegetable), marrow; its fruit may be called ''marrow'' when mature. Ordinary zucchini fruit are any shade of green, though the golden zucchini is a deep yellow or orange. At maturity, they can grow to nearly in length, but they are normally harvested at about . In botany, the zucchini's fruit is a Berry (botany)#Modified berries, pepo, a Berry (botany), berry (the swollen ovary (botany), ovary of the squash blossom, zucchini flower) with a hardened epicarp. In cookery, it is treated as a vegetable, usually cooked and eaten as an accompaniment or savory dish, though occasionally used in sweeter cooking. Zucchini occasionally contain toxic cucurbitacins, making them extre ...
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Cucumber
The cucumber (''Cucumis sativus'') is a widely-cultivated creeping vine plant in the family Cucurbitaceae that bears cylindrical to spherical fruits, which are used as culinary vegetables.Cucumber
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Considered an annual plant, there are three main types of cucumber—slicing, pickling, and seedless—within which several

Hebeloma
''Hebeloma'' is a genus of fungi in the family Hymenogastraceae. Found worldwide, it contains the poison pie or fairy cakes ''(Hebeloma crustuliniforme)'' and the ghoul fungus ''(Hebeloma aminophilum, H. aminophilum)'', from Western Australia, which grows on rotting animal remains. Taxonomy The placement of the genus ''Hebeloma'' within the fungal taxonomic tree has varied over time. Historically it has been most often placed in the order Agaricales but was placed Cortinariales in the 8th edition of the Dictionary of the Fungi. The most recent inter-generic placement (Knudsen & Vesterholt, 2nd ed, 2012)) places it the family Hymenogastraceae within Agaricales. Etymology The generic name is a compound Ancient Greek word ''hēbē'' (ἥβη), "youth" or "puberty" and the suffix -''loma'' (λόμα), a fringe (pertaining to the Veil (mycology), fungal veil). Thus, ''Hebeloma'' translates as "fringe of youth", in reference to how the fungal veil is only seen in immature specimens ...
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Russula
''Russula'' is a very large genus composed of around 750 worldwide species of fungi. The genus was described by Christian Hendrik Persoon in 1796. The mushrooms are fairly large, and brightly colored – making them one of the most recognizable genera among mycologists and mushroom collectors. Their distinguishing characteristics include usually brightly coloured caps, a white to dark yellow spore print, brittle, attached gills, an absence of latex, and absence of partial veil or volva tissue on the stem. Microscopically, the genus is characterised by the amyloid ornamented spores and flesh (trama) composed of spherocysts. Members of the related genus ''Lactarius'' have similar characteristics but emit a milky latex when their gills are broken. The ectomycorrhizal mushrooms are typically common. Although some species are toxic, a number of others are edible. Taxonomy Christian Hendrik Persoon first circumscribed the genus ''Russula'' in his 1796 work ''Observationes Mycologi ...
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