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''Andrographis paniculata'', commonly known as creat or green chiretta, is an annual herbaceous plant in the family Acanthaceae, native to India and Sri Lanka. It is widely cultivated in Southern and Southeastern Asia, where it has been believed to be a treatment for bacterial infections and some diseases. Mostly the leaves and roots have been used for such purposes; the whole plant is also used, in some cases. Description The plant grows as an erect herb to a height of in moist, shady places. The slender stem is dark green, square in cross-section with longitudinal furrows and wings along the angles. The lance-shaped leaves have hairless blades measuring up to long by . The small flowers are pink, solitary, arranged in lax spreading racemes or panicles. The fruit is a capsule around long and a few millimeters wide. It contains many yellow-brown seeds. The seeds are subquadrate, rugose and glabrous. The flowering time is September to December. Distribution The species is di ...
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Nicolaas Laurens Burman
Nicolaas Laurens Burman (27 December 1734 – 11 September 1793) was a Dutch botanist. He was the son of Johannes Burman (1707–1780). He succeeded his father to the chair of botany at the Athenaeum Illustre of Amsterdam., and at the Hortus Botanicus (Amsterdam), Hortus Botanicus. He continued the correspondence with Carl Linnaeus, joining him at the University of Uppsala in 1760. He is the author of numerous works including ''Specimen botanicum de geraniis'' (1759) and ''Flora Indica'' (1768) which was later completed by Johann Gerhard Koenig (1728–1785). Works * References

* 1734 births 1793 deaths 18th-century Dutch botanists Scientists from Amsterdam Academic staff of the University of Amsterdam Age of Liberty people {{Netherlands-botanist-stub ...
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Siddha Medicine
Siddha medicine is a form of traditional medicine originating in southern India. It is one of the oldest systems of medicine in India. The Indian Medical Association regards Siddha medicine degrees as "fake" and Siddha therapies as quackery, posing a danger to national health due to absence of training in science-based medicine. Identifying fake medical practitioners without qualifications, the Supreme Court of India stated in 2018 that "unqualified, untrained quacks are posing a great risk to the entire society and playing with the lives of people without having the requisite training and education in the science from approved institutions". In rural India, have learned methods traditionally through master-disciple relationships to become local "healers" known as siddhars. are among an estimated 400,000 traditional healers practicing medicine in India, comprising some 57% of rural medical care. Siddha practitioners believe that five basic elements – earth, water, fire, ...
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Xiyanping
Xiyanping (喜炎平) is an anti-inflammatory and antiviral preparation developed and licensed for use in China China, officially the People's Republic of China (PRC), is a country in East Asia. With population of China, a population exceeding 1.4 billion, it is the list of countries by population (United Nations), second-most populous country after .... It is a semi-synthetic injectable product derived from the active component of the plant ''Andrographis paniculata'' (Chuan Xin Lian, 穿心蓮), which is used in Traditional Chinese medicine. Xiyanping is primarily composed of 9-dehydro-17-hydro-andrographolide and sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate. It is used mainly in the treatment of hand, foot and mouth disease, diarrhea, upper respiratory tract infections and viral pneumonia, though one case report suggested it may also be useful in the treatment of Zika fever. Side effects Xiyanping injection may be associated with side effects typical of al ...
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Andrographolide
Andrographolide is a labdane diterpenoid that has been isolated from the stem and leaves of ''Andrographis paniculata''. Andrographolide is an extremely bitter substance. Andrographolide has been studied for its effects on cell signaling, immunomodulation, and stroke. Study has shown that andrographolide may bind to a spectrum of protein targets including NF-κB and actin by covalent modification. Andrographolide is a non-ATP-competitive, substrate-competitive GSK-3β inhibitor. When the substrate concentration is 25µM, the IC50 of andrographolide for GSK-3β is 5.58±0.40µM. When the substrate concentration is increased to 90µM, the IC50 increases to 37.7µM. Biosynthesis While andrographolide is a relatively simple diterpene lactone, the biosynthesis by Andrographis paniculata was determined in the 2010s. Andrographolide is a member of the isoprenoid family of natural products. The precursors to isoprenoid biosynthesis, isopentenyl pyrophosphate (IPP) and dimethylallyl ...
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Department Of Corrections (Thailand)
The Department of Corrections (, ) is an agency of the Thai Ministry of Justice. Its mission is to keep prisoners in custody and rehabilitate them. Its headquarters is in Suanyai Sub-district, Mueang Nonthaburi District, Nonthaburi Province. , Police Colonel Suchart Wongananchai is director-general of the department. Its FY2019 budget was 13,430 million baht. Prisons and prison population * Despite its population of only 70 million, Thailand ranks sixth in the world in prison population. * Thailand's female incarceration rate is the world's highest at 66.4 female convicts per 100,000 inhabitants. * The department manages 143 or 144 central prisons, provincial prisons, district prisons and other correctional facilities across Thailand, housing some 45,796 female (13.7 percent) and 288,483 male prisoners. Overcrowding has been reported at 143 prisons. The official capacity of all Thai prisons was 217,000 . By early 2020 the prison population had grown to 374,052 inmates, 288, ...
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Cabinet Of Thailand
The cabinet of Thailand (formally, the Council of Ministers of Thailand; ; is a body composed of thirty-five of the most senior members of the government of the Kingdom of Thailand. The Cabinet (government), cabinet is the primary organ of the executive branch of the Government of Thailand, Thai government. Members of the cabinet are nominated by the Prime Minister of Thailand, prime minister and formally appointed by the King of Thailand. Most members are governmental department heads with the title of "minister of state" (; . The cabinet is chaired by the Prime Minister of Thailand. The cabinet is often collectively called "the government" or "the Royal Thai Government". History Prior to the Siamese Revolution of 1932, Revolution of 1932, the absolutist House of Chakri, Chakri kings ruled Siam through a series of "krom" ( and "senabodi" (. On 15 April 1874 King Chulalongkorn founded the Privy Council (Thailand), King's Privy Council () (which still exists today) made up of ...
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Ministry Of Public Health (Thailand)
The Ministry of Public Health (MOPH; , ) is a Government of Thailand, Thai governmental body responsible for the oversight of Health in Thailand, public health in Thailand. It is commonly referred to in Thailand by its abbreviation ''so tho'' (). The headquarters of the ministry is located in Mueang Nonthaburi District, Mueang Nonthaburi, Nonthaburi, and served by Ministry of Public Health MRT station on the MRT Purple Line. History In Thailand before 1888 there were no permanent, public hospitals to provide care to sick people. Temporary hospitals were set up to care for patients during epidemics, then disbanded when the epidemic subsided. Under King Chulalongkorn (Rama V) a hospital was constructed and completed in 1888 and named "Siriraj Hospital" in commemoration of the king's young son, Prince Siriraj Kakudhabhand, who had died of dysentery. King Vajiravudh, King Chulalongkorn's successor, established Department of Health on 27 November 1918. During the reign of King Rama VI ...
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COVID-19
Coronavirus disease 2019 (COVID-19) is a contagious disease caused by the coronavirus SARS-CoV-2. In January 2020, the disease spread worldwide, resulting in the COVID-19 pandemic. The symptoms of COVID‑19 can vary but often include fever, fatigue, cough, breathing difficulties, anosmia, loss of smell, and ageusia, loss of taste. Symptoms may begin one to fourteen days incubation period, after exposure to the virus. At least a third of people who are infected asymptomatic, do not develop noticeable symptoms. Of those who develop symptoms noticeable enough to be classified as patients, most (81%) develop mild to moderate symptoms (up to mild pneumonia), while 14% develop severe symptoms (dyspnea, hypoxia (medical), hypoxia, or more than 50% lung involvement on imaging), and 5% develop critical symptoms (respiratory failure, shock (circulatory), shock, or organ dysfunction, multiorgan dysfunction). Older people have a higher risk of developing severe symptoms. Some complicati ...
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Respiratory Tract Infection
Respiratory tract infections (RTIs) are infectious diseases involving the lower or upper respiratory tract. An infection of this type usually is further classified as an upper respiratory tract infection (URI or URTI) or a lower respiratory tract infection (LRI or LRTI). Lower respiratory infections, such as pneumonia, tend to be far more severe than upper respiratory infections, such as the common cold. Types Upper respiratory tract infection The upper respiratory tract is considered the airway above the glottis or vocal cords; sometimes, it is taken as the tract above the cricoid cartilage. This part of the tract includes the nose, sinuses, pharynx, and larynx. Typical infections of the upper respiratory tract include tonsillitis, pharyngitis, laryngitis, sinusitis, otitis media, certain influenza types, and the common cold. Symptoms of URIs can include cough, sore throat, runny nose, nasal congestion, headache, low-grade fever, facial pressure, and sneezing. Lower respira ...
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Meta-analysis
Meta-analysis is a method of synthesis of quantitative data from multiple independent studies addressing a common research question. An important part of this method involves computing a combined effect size across all of the studies. As such, this statistical approach involves extracting effect sizes and variance measures from various studies. By combining these effect sizes the statistical power is improved and can resolve uncertainties or discrepancies found in individual studies. Meta-analyses are integral in supporting research grant proposals, shaping treatment guidelines, and influencing health policies. They are also pivotal in summarizing existing research to guide future studies, thereby cementing their role as a fundamental methodology in metascience. Meta-analyses are often, but not always, important components of a systematic review. History The term "meta-analysis" was coined in 1976 by the statistician Gene V. Glass, Gene Glass, who stated ''"Meta-analysis refers t ...
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Jaundice
Jaundice, also known as icterus, is a yellowish or, less frequently, greenish pigmentation of the skin and sclera due to high bilirubin levels. Jaundice in adults is typically a sign indicating the presence of underlying diseases involving abnormal heme metabolism, liver dysfunction, or biliary-tract obstruction. The prevalence of jaundice in adults is rare, while jaundice in babies is common, with an estimated 80% affected during their first week of life. The most commonly associated symptoms of jaundice are itchiness, pale feces, and dark urine. Normal levels of bilirubin in blood are below 1.0  mg/ dl (17  μmol/ L), while levels over 2–3 mg/dl (34–51 μmol/L) typically result in jaundice. High blood bilirubin is divided into two types: unconjugated and conjugated bilirubin. Causes of jaundice vary from relatively benign to potentially fatal. High unconjugated bilirubin may be due to excess red blood cell breakdown, large bruises, gen ...
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