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Coot (program)
The program Coot (Crystallographic Object-Oriented Toolkit) is used to display and manipulate atomic models of macromolecules, typically of proteins or nucleic acids, using 3D computer graphics. It is primarily focused on building and validation of atomic models into three-dimensional Resolution (electron density), electron density maps obtained by X-ray crystallography methods, although it has also been applied to data from electron microscopy. Overview Coot displays electron density maps and atomic models and allows model manipulations such as idealization, real space refinement, manual rotation/translation, rigid-body fitting, ligand search, solvation, mutations, rotamers, and Ramachandran plot, Ramachandran idealization. The software is designed to be easy-to-learn for novice users, achieved by ensuring that tools for common tasks are 'discoverable' through familiar user interface elements (menus and toolbars), or by intuitive behaviour (mouse controls). Recent developments hav ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Emsley (crystallographer)
Paul Emsley is a British crystallography, crystallographer at the Laboratory of Molecular Biology, MRC Laboratory of Molecular Biology in Cambridge. He works as an independent scientist and is a member of the Computational Crystallography Group headed by Garib Murshudov. Emsley is the primary author of the model-building software Coot (software), Coot,Emsley, P., Lohkamp, B., Scott, W.G. and Cowtan, K., 2010Features and development of Coot ''Acta Crystallographica Section D'', ''66''(4), pp.486-501. a tool for building models of proteins whose three dimensional structures are determined via X-ray crystallography or Cryo-electron microscopy, cryo-EM. These protein structures are deposited at the Worldwide Protein Data Bank for collaboration among scientists. Since its introduction in 2004, Coot has remained as free software for use in industrial and academic research groups. Emsley has given lectures and tutorials on model-building and validation at Cold Spring Harbor Laboratory an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |