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Clb 5,6 (Cdk1)
Clb5 and Clb6 are B-type, S-phase cyclins in yeast that assist in cell cycle regulation.Morgan, DO (2007) 'The Cell Cycle: Principles of Control, Oxford University Press Clb5 and Clb6 bind and activate Cdk1, and high levels of these cyclins are required for entering S-phase.Schwob, E. and K. Nasmyth (1993). "CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae." Genes & development 7(7a): 1160. S-phase cyclin binding to Cdk1 directly stimulates DNA replication as well as progression to the next phase of the cell cycle.Stuart, D. and C. Wittenberg (1998). "CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint." Genes & development 12(17): 2698. Structure Clb5 and Clb6 are two of the six B-type cyclins in Saccharomyces cerevisiae, budding yeast, which contain a short, hydrophobic amino acid sequence that allows targeted degradation and phosphorylation of some proteins that regulate DNA replicatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclins
Cyclins are proteins that control the progression of a cell through the cell cycle by activating cyclin-dependent kinases (CDK). Etymology Cyclins were originally discovered by R. Timothy Hunt in 1982 while studying the cell cycle of sea urchins. In an interview hosted by Jim Al-Khalili and R. Timothy Hunt for "The Life Scientific", which aired on December 13, 2011, explained that the name "cyclin" was originally named after his hobby cycling. It was only after the naming did its importance in the cell cycle become apparent. As it was appropriate, the name stuck. R. Timothy Hunt: "By the way, the name cyclin, which I coined, was really a joke, it's because I liked cycling so much at the time, but they did come and go in the cell..." Function Cyclins were originally named because their concentration varies in a cyclical fashion during the cell cycle. (Note that the cyclins are now classified according to their conserved cyclin box structure, and not all these cyclins alt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |