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Chihuahua (dog Breed)
The Chihuahua (or ) is a Mexican list of dog breeds, breed of toy dog. It is named for the Mexican state of Chihuahua (state), Chihuahua and is one of the smallest dog breeds in the world. It is usually kept as a companion animal. History DNA studies suggest that native American dogs entered North America from Siberia roughly 10,000 years ago, and were then isolated for some 9,000 years until the arrival of the first Europeans; these pre-contact dogs exhibited a unique genetic signature that is now almost gone. A study based on sequencing of ancient dog genomes, published in 2020, suggests that this pre-colonial ancestry survives in two Mexican breeds, to the extent of about 4% in the Chihuahua (and some 3% in the Xoloitzcuintle, Xoloitzcuintli). Other studies have suggested that the pre-colonial ancestry of the Chihuahua may be as high as 70%. Colonial records refer to small, nearly hairless dogs at the beginning of the nineteenth century; one claims that sixteenth-century ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Merle (dog Coat)
Merle is a genetic pattern in a dog's coat and alleles of the PMEL gene. It results in different colors and patterns and can affect any coats. The allele creates mottled patches of color in a solid or piebald coat, blue or odd-colored eyes, and can affect skin pigment as well. Two types of colored patches generally appear in a merle coat: brown/liver (red merle) and black (blue merle). Associated breeds include Carea Leonés, Australian Shepherds and Catahoula Leopard Dogs. Health issues are more typical and more severe when two merle-patterned dogs are bred together. Description Merle can affect all coat colors. The merle forms of brown are usually called "red" (though this is not correct; red and brown are genetically different), and black is called "blue" as lighter patches of black are formed throughout the coat and look slightly blue in color. Dogs who are recessive red can still be affected by merle, but the patches are either hardly seen or, if the dog is a cle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fédération Cynologique Internationale
The (; FCI; ) is the largest international federation of national kennel clubs and purebred registries. The FCI is based in Thuin, Belgium and has 98 members and contract partners (one from each country). History The FCI was founded in 1911 under the auspices of the kennel clubs of Austria, Belgium, France, Germany and the Netherlands. Its objective was to bring global uniformity to the breeding, exhibiting and judging of pure-bred dogs. It was disbanded in World War I and recreated in 1921 by Belgium and France. Since its foundation the FCI's membership has grown to include kennel clubs from the majority of countries worldwide, with members in Europe as well as Africa, the Americas, Asia and Oceania. Function The purpose of the FCI is to make sure that the pedigrees and judges are mutually recognised by all the FCI member countries. In contrast to national kennel clubs, the FCI is not a registry and does not issue pedigrees to individual dogs, with the issue of pedigrees and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroaxonal Dystrophy
Infantile neuroaxonal dystrophy (INAD) is a rare pervasive developmental disorder that primarily affects the nervous system. Individuals with infantile neuroaxonal dystrophy typically do not have any symptoms at birth, but between the ages of about 6 and 18 months they begin to experience delays in acquiring new motor and intellectual skills, such as crawling or beginning to speak. Eventually, they lose previously acquired skills. Presentation Cause This condition is inherited in an autosomal recessive pattern, which means two copies of the gene (''PLA2G6'') in each cell are altered. Most often, the parents of an individual with an autosomal recessive disorder each carry one copy of the altered gene but do not show signs and symptoms of the disorder. Pathophysiology Mutations in the '' PLA2G6'' gene have been identified in most individuals with infantile neuroaxonal dystrophy. The ''PLA2G6'' gene provides instructions for making an enzyme called an A2 phospholipase. This enzy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Necrotizing Meningoencephalitis
Necrotizing meningoencephalitis (NME) is a fatal inflammatory central nervous system (CNS) disorder in dogs, where an extensive cerebral necrosis is associated with a multifocal, non-suppurative meningoencephalitis of the neuro cortex. It was originally identified and recorded in the 1960s in pure breed pugs, with which this disease is nowadays mostly associated with, occurring essentially in small breed dogs ranging from six months to seven years of age. It causes intense necrotizing inflammatory lesions in the brain stem and Cerebellum. The cause is still unclear. The pathogen that triggers the disease and contributes to its development has not yet been identified. It is presumed to have a multifactorial, heritable, autoimmune etiology. The process is rapidly progressive, culminating in status epilepticus and ending fatally for the dog. Although the pattern of inflammation is similar to other neuropathological conditions, resembling CNS inflammatory diseases which produces lesion ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Muscular Dystrophy
Muscular dystrophies (MD) are a genetically and clinically heterogeneous group of rare neuromuscular diseases that cause progressive weakness and breakdown of skeletal muscles over time. The disorders differ as to which muscles are primarily affected, the degree of weakness, how fast they worsen, and when symptoms begin. Some types are also associated with problems in other human organs, organs. Over 30 different disorders are classified as muscular dystrophies. Of those, Duchenne muscular dystrophy (DMD) accounts for approximately 50% of cases and affects males beginning around the age of four. Other relatively common muscular dystrophies include Becker muscular dystrophy, facioscapulohumeral muscular dystrophy, and myotonic dystrophy, whereas limb–girdle muscular dystrophy and congenital muscular dystrophy are themselves groups of several – usually extremely rare – genetic disorders. Muscular dystrophies are caused by mutations in genes, usually those involved in making ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Congenital Hydrocephalus
Hydrocephalus is a condition in which cerebrospinal fluid (CSF) builds up within the brain, which can cause pressure to increase in the skull. Symptoms may vary according to age. Headaches and double vision are common. Elderly adults with normal pressure hydrocephalus (NPH) may have poor balance, difficulty controlling urination, or mental impairment. In babies, there may be a rapid increase in head size. Other symptoms may include vomiting, sleepiness, seizures, and downward pointing of the eyes. Hydrocephalus can occur due to birth defects (primary) or can develop later in life (secondary). Hydrocephalus can be classified via mechanism into communicating, noncommunicating, ''ex vacuo'', and normal pressure hydrocephalus. Diagnosis is made by physical examination and medical imaging, such as a CT scan. Hydrocephalus is typically treated through surgery. One option is the placement of a shunt system. A procedure called an endoscopic third ventriculostomy has gained popu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Congenital Deafness
Hearing loss is a partial or total inability to hear. Hearing loss may be present at birth or acquired at any time afterwards. Hearing loss may occur in one or both ears. In children, hearing problems can affect the ability to acquire spoken language, and in adults it can create difficulties with social interaction and at work. Hearing loss can be temporary or permanent. Hearing loss related to age usually affects both ears and is due to cochlear hair cell loss. In some people, particularly older people, hearing loss can result in loneliness. Hearing loss may be caused by a number of factors, including: genetics, ageing, exposure to noise, some infections, birth complications, trauma to the ear, and certain medications or toxins. A common condition that results in hearing loss is chronic ear infections. Certain infections during pregnancy, such as cytomegalovirus, syphilis and rubella, may also cause hearing loss in the child. Hearing loss is diagnosed when hearing tes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ceroid Lipofuscinosis
Neuronal ceroid lipofuscinosis is a family of at least eight genetically separate neurodegenerative lysosomal storage diseases that result from excessive accumulation of lipopigments (lipofuscin) in the body's tissues. These lipopigments are made up of fats and proteins. Their name comes from the word stem "lipo-", which is a variation on lipid, and from the term "pigment", used because the substances take on a greenish-yellow color when viewed under an ultraviolet light microscope. These lipofuscin materials build up in neuronal cells and many organs, including the liver, spleen, myocardium, and kidneys. Signs and symptoms The classic characterization of the group of neurodegenerative, lysosomal storage disorders called the neuronal ceroid lipofuscinoses (NCLs) is through the progressive, permanent loss of motor and psychological ability with a severe intracellular accumulation of lipofuscins, with the United States and Northern European populations having slightly higher freque ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atlantoaxial Instability
In anatomy, the transverse ligament of the atlas is a broad, tough ligament which arches across the ring of the atlas (first cervical vertebra) posterior to the dens to keep the dens (odontoid process) in contact with the atlas. It forms the transverse component of the cruciform ligament of atlas. Structure The length of the ligament is variable; its mean length is 2 cm. The ligament broadens and thickensGray's anatomy, 1918 medially. The anterior medial aspect of the ligament is lined by a thin layer of articular cartilage. The neck of the odontoid process is constricted where it is embraced posteriorly by the transverse ligament so it retains the dens in position even after all other ligaments have been sectioned. Attachments The ligament attaches on either side onto a small yet prominent tubercle upon the medial aspect of either lateral mass of atlas. Cruciate ligament A strong median band (''crus superius'') extends superiorly from the superior margin of the ligamen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurological Disease
Neurological disorders represent a complex array of medical conditions that fundamentally disrupt the functioning of the nervous system. These disorders affect the brain, spinal cord, and nerve networks, presenting unique diagnosis, treatment, and patient care challenges. At their core, they represent disruptions to the intricate communication systems within the nervous system, stemming from genetic predispositions, environmental factors, infections, structural abnormalities, or degenerative processes. The impact of neurological disorders is profound and far-reaching. Conditions like epilepsy create recurring seizures through abnormal electrical brain activity, while multiple sclerosis damages the protective myelin covering of nerve fibers, interrupting communication between the brain and body. Parkinson's disease progressively affects movement through the loss of dopamine-producing nerve cells, and strokes can cause immediate and potentially permanent neurological damage by interr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Predisposition
Genetic predisposition refers to a genetic characteristic which influences the possible phenotypic development of an individual organism within a species or population under the influence of environmental conditions. The term genetic susceptibility is often used synonymously with genetic predisposition and is further defined as the inherited risk for specific conditions, based on genetic variants. While environmental factors can influence disease onset, genetic predisposition plays a role in inherited risk of conditions, such as various cancers. At the molecular level, genetic predisposition often involves specific gene mutation, regulatory pathways, or epigenetic modifications that alter cellular processes, increasing disease risk. How to predict genetic predisposition There are several approaches commonly used in the field of genetics to predict a genetic predisposition toward a disease. * Genome-Wide Association Studies (GWAS): studies that identify genetic variants link ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Kennel Club
The Royal Kennel Club (KC) is the official kennel club of the United Kingdom. It is the oldest recognised kennel club in the world. Its role is to oversee various canine activities including dog shows, dog agility and working trials. It also operates the national register of pedigree dogs in the United Kingdom and acts as a lobby group on issues involving dogs in the UK. To celebrate its 150th anniversary on 5 April 2023, King Charles III confirmed the club with a 'royal' prefix. The Kennel Club has four principal physical locations. Its headquarters are on Clarges Street in Mayfair, London, incorporating a private members' club (with bar, lounge, and dining facilities), meeting and conference rooms, art gallery, library, picture library, and a residential apartment for the use of the Chairman. A second site at Aylesbury, Buckinghamshire, houses the administrative offices, and charitable trust headquarters. The third site is Stoneleigh Park in Warwickshire, where the Kenn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
