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Cheddar Man
Cheddar Man is a human male skeleton found in Gough's Cave in Cheddar Gorge, Somerset, England. The skeletal remains date to around the mid-to-late 9th millennium BC, corresponding to the Mesolithic period, and it appears that he died a violent death. A large crater-like lesion just above the skull's right orbit suggests that the man may have also been suffering from a bone infection. Excavated in 1903, Cheddar Man is Britain's oldest near-complete human skeleton. The remains are kept by London's Natural History Museum, in the Human Evolution gallery. Analysis of his nuclear DNA indicates that he was a typical member of the Western European hunter-gatherer population at the time, with a most likely phenotype of blue-green eyes, dark brown or black hair, and dark or dark-to-black skin, with no genetic adaption for lactase persistence into adulthood. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cheddar, Somerset
Cheddar is a large village and civil parish in the English county of Somerset. It is situated on the southern edge of the Mendip Hills, north-west of Wells, south-east of Weston-super-Mare and south-west of Bristol. The civil parish includes the hamlets of Nyland and Bradley Cross. The parish had a population of 5,755 in 2011 and an acreage of as of 1961. Cheddar Gorge, on the northern edge of the village, is the largest gorge in the United Kingdom and includes several show caves, including Gough's Cave. The gorge has been a centre of human settlement since Neolithic times, including a Saxon palace. It has a temperate climate and provides a unique geological and biological environment that has been recognised by the designation of several Sites of Special Scientific Interest. It is also the site of several limestone quarries. The village gave its name to Cheddar cheese and has been a centre for strawberry growing. The crop was formerly transported on the Cheddar Valley ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cold And Heat Adaptations In Humans
Cold and heat adaptations in humans are a part of the broad adaptability of ''Homo sapiens''. Adaptations in humans can be physiological, genetic, or cultural, which allow people to live in a wide variety of climates. There has been a great deal of research done on developmental adjustment, acclimatization, and cultural practices, but less research on genetic adaptations to colder and hotter temperatures. The human body always works to remain in homeostasis. One form of homeostasis is thermoregulation. Body temperature varies in every individual, but the average internal temperature is . Sufficient stress from extreme external temperature may cause injury or death if it exceeds the ability of the body to thermoregulate. Hypothermia can set in when the core temperature drops to . Hyperthermia can set in when the core body temperature rises above . Humans have adapted to living in climates where hypothermia and hyperthermia were common primarily through culture and technology, such a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neolithic
The Neolithic or New Stone Age (from Ancient Greek, Greek 'new' and 'stone') is an archaeological period, the final division of the Stone Age in Mesopotamia, Asia, Europe and Africa (c. 10,000 BCE to c. 2,000 BCE). It saw the Neolithic Revolution, a wide-ranging set of developments that appear to have arisen independently in several parts of the world. This "Neolithic package" included the History of agriculture, introduction of farming, domestication of animals, and change from a hunter-gatherer lifestyle to one of sedentism, settlement. The term 'Neolithic' was coined by John Lubbock, 1st Baron Avebury, Sir John Lubbock in 1865 as a refinement of the three-age system. The Neolithic began about 12,000 years ago, when farming appeared in the Epipalaeolithic Near East and Mesopotamia, and later in other parts of the world. It lasted in the Near East until the transitional period of the Chalcolithic (Copper Age) from about 6,500 years ago (4500 BCE), marked by the development ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vitamin D
Vitamin D is a group of structurally related, fat-soluble compounds responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, along with numerous other biological functions. In humans, the most important compounds within this group are vitamin D3 ( cholecalciferol) and vitamin D2 ( ergocalciferol). Unlike the other twelve vitamins, vitamin D is only conditionally essential, as with adequate skin exposure to the ultraviolet B (UVB) radiation component of sunlight there is synthesis of cholecalciferol in the lower layers of the skin's epidermis. For most people, skin synthesis contributes more than diet sources. Vitamin D can also be obtained through diet, food fortification and dietary supplements. In the U.S., cow's milk and plant-based milk substitutes are fortified with vitamin D3, as are many breakfast cereals. Government dietary recommendations typically assume that all of a person's vitamin D is taken by mouth, given the potential for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Light Skin
Light skin is a human skin color that has a low level of eumelanin pigmentation as an adaptation to environments of low Ultraviolet, UV radiation. Due to migrations of people in recent centuries, light-skinned populations today are found all over the world. Light skin is most commonly found amongst the native populations of Europe, East Asia, West Asia, Central Asia, South Asia, Siberia, and North Africa as measured through skin reflectance. People with light skin pigmentation are often referred to as "White people, white" although these usages can be ambiguous in some countries where they are used to refer specifically to certain ethnic groups or populations. Humans with light skin pigmentation have skin with low amounts of eumelanin, and possess fewer melanosomes than humans with dark skin pigmentation. Light skin provides better absorption qualities of ultraviolet radiation, which helps the body to synthesize higher amounts of vitamin D for bodily processes such as calcium de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome-wide Association Study
In genomics, a genome-wide association study (GWA study, or GWAS), is an observational study of a genome-wide set of Single-nucleotide polymorphism, genetic variants in different individuals to see if any variant is associated with a trait. GWA studies typically focus on associations between single-nucleotide polymorphisms (SNPs) and traits like major human diseases, but can equally be applied to any other genetic variants and any other organisms. When applied to human data, GWA studies compare the DNA of participants having varying phenotypes for a particular trait or disease. These participants may be people with a disease (cases) and similar people without the disease (controls), or they may be people with different phenotypes for a particular trait, for example blood pressure. This approach is known as phenotype-first, in which the participants are classified first by their clinical manifestation(s), as opposed to Genotype-first approach, genotype-first. Each person gives a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Single-nucleotide Polymorphism
In genetics and bioinformatics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently large fraction of the population (e.g. 1% or more), many publications do not apply such a frequency threshold. For example, a Guanine, G nucleotide present at a specific location in a reference genome may be replaced by an Adenine, A in a minority of individuals. The two possible nucleotide variations of this SNP – G or A – are called alleles. SNPs can help explain differences in susceptibility to a wide range of diseases across a population. For example, a common SNP in the Factor H, CFH gene is associated with increased risk of age-related macular degeneration. Differences in the severity of an illness or response to treatments may also be manifestations of genetic variations caused by SNPs. For example, two ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Multinomial Logistic Regression
In statistics, multinomial logistic regression is a classification method that generalizes logistic regression to multiclass problems, i.e. with more than two possible discrete outcomes. That is, it is a model that is used to predict the probabilities of the different possible outcomes of a categorically distributed dependent variable, given a set of independent variables (which may be real-valued, binary-valued, categorical-valued, etc.). Multinomial logistic regression is known by a variety of other names, including polytomous LR, multiclass LR, softmax regression, multinomial logit (mlogit), the maximum entropy (MaxEnt) classifier, and the conditional maximum entropy model. Background Multinomial logistic regression is used when the dependent variable in question is nominal (equivalently ''categorical'', meaning that it falls into any one of a set of categories that cannot be ordered in any meaningful way) and for which there are more than two categories. Some example ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eye Color
Eye color is a polygene, polygenic phenotypic trait determined by two factors: the pigmentation of the eye's Iris (anatomy), iris and the frequency-dependence of the scattering of light by the Turbidity, turbid medium in the Stroma of iris, stroma of the iris. In humans, the pigmentation of the Iris (anatomy), iris varies from light brown to black, depending on the concentration of melanin in the iris pigment epithelium (located on the back of the iris), the melanin content within the iris stroma (located at the front of the iris), and the cellular density of the stroma. The appearance of blue, green, and hazel eyes results from the Tyndall effect, Tyndall scattering of light in the stroma, a phenomenon similar to Rayleigh scattering which accounts for the blue sky. Neither blue nor green pigments are present in the human iris or vitreous humour. This is an example of structural color, which depends on the lighting conditions, especially for lighter-colored eyes. The brightly c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coverage (genetics)
In genetics, coverage is one of several measures of the depth or completeness of DNA sequencing, and is more specifically expressed in any of the following terms: *Sequence coverage (or depth) is the number of unique reads that include a given nucleotide in the reconstructed sequence. Deep sequencing refers to the general concept of aiming for high number of unique reads of each region of a sequence. *Physical coverage, the cumulative length of reads or read pairs expressed as a multiple of genome size. *Genomic coverage, the percentage of all base pairs or loci of the genome covered by sequencing. Sequence coverage Rationale Even though the sequencing accuracy for each individual nucleotide is very high, the very large number of nucleotides in the genome means that if an individual genome is only sequenced once, there will be a significant number of sequencing errors. Furthermore, many positions in a genome contain rare single-nucleotide polymorphisms (SNPs). Hence to distingu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Single-nucleotide Polymorphism
In genetics and bioinformatics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently large fraction of the population (e.g. 1% or more), many publications do not apply such a frequency threshold. For example, a Guanine, G nucleotide present at a specific location in a reference genome may be replaced by an Adenine, A in a minority of individuals. The two possible nucleotide variations of this SNP – G or A – are called alleles. SNPs can help explain differences in susceptibility to a wide range of diseases across a population. For example, a common SNP in the Factor H, CFH gene is associated with increased risk of age-related macular degeneration. Differences in the severity of an illness or response to treatments may also be manifestations of genetic variations caused by SNPs. For example, two ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New Scientist
''New Scientist'' is a popular science magazine covering all aspects of science and technology. Based in London, it publishes weekly English-language editions in the United Kingdom, the United States and Australia. An editorially separate organisation publishes a monthly Dutch-language edition. First published on 22 November 1956, ''New Scientist'' has been available in online form since 1996. Sold in retail outlets (paper edition) and on subscription (paper and/or online), the magazine covers news, features, reviews and commentary on science, technology and their implications. ''New Scientist'' also publishes speculative articles, ranging from the technical to the philosophical. ''New Scientist'' was acquired by Daily Mail and General Trust (DMGT) in March 2021. History Ownership The magazine was founded in 1956 by Tom Margerison, Max Raison and Nicholas Harrison as ''The New Scientist'', with Issue 1 on 22 November 1956, priced at one shilling (). An article in the magazi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
