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Burkitt's
Burkitt's lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center. It is named after Denis Parsons Burkitt, the Irish surgeon who first described the disease in 1958 while working in equatorial Africa. It is a highly aggressive form of cancer which often, but not always, manifests after a person develops acquired immunodeficiency from infection with Epstein-Barr Virus or Human Immunodeficiency Virus (HIV). The overall cure rate for Burkitt's lymphoma in developed countries is about 90%. Burkitt's lymphoma is uncommon in adults, in whom it has a worse prognosis. Classification Burkitt lymphoma can be divided into three main clinical variants: the endemic, the sporadic, and the immunodeficiency-associated variants. By morphology (i.e., microscopic appearance), immunophenotype, and genetics, the variants of Burkitt lymphoma are alike. * The endemic variant (also called "African variant") most commonly occurs in children living in r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Denis Parsons Burkitt
Denis Parsons Burkitt, MD, FRCS(Ed), FRS (28 February 1911 – 23 March 1993) was an Irish surgeon who made significant advances in health, such as the aetiology of a pediatric cancer, now called Burkitt's lymphoma, and the finding that rates of colorectal cancer are higher in those who eat limited dietary fibre. Biography Burkitt was born in Enniskillen, County Fermanagh, Ireland. He was the son of James Parsons Burkitt, a civil engineer. Aged eleven he lost his right eye in an accident. He attended Portora Royal School in Enniskillen and Dean Close School, England. In 1929 Burkitt entered Trinity College, Dublin to study engineering, but believing his evangelical calling was to be a doctor, he transferred to medicine and graduated in 1935. In 1938 he passed the Royal College of Surgeons of Edinburgh fellowship examinations. On 28 July 1943 he married Olive Rogers. During World War II, Burkitt served with the Royal Army Medical Corps in England and later in Kenya and So ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epstein–Barr Virus
The Epstein–Barr virus (EBV), also known as human herpesvirus 4 (HHV-4), is one of the nine known Herpesviridae#Human herpesvirus types, human herpesvirus types in the Herpesviridae, herpes family, and is one of the most common viruses in humans. EBV is a DNA virus#Double-stranded DNA viruses, double-stranded DNA virus. EBV is the first identified oncogenic virus, a virus that can cause cancer. EBV establishes permanent infection in human B cells. It uncommonly causes infectious mononucleosis and is also tightly linked to many Malignancy, malignant diseases (cancers and autoimmune diseases). Various vaccine formulations have been tested in animals and humans; however, none of them were able to prevent EBV infection, thus, no vaccine has been approved to date. Infectious mononucleosis ("mono" or "glandular fever"), is characterized by extreme fatigue, fever, sore throat, and swollen lymph nodes. EBV is also associated with various non-malignant, premalignant, and malignant E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Germinal Center
Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes, ileal Peyer's patches, and the spleen – where mature B cells are activated, proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation aimed at achieving higher affinity) during a normal immune response; most of the germinal center B cells (BGC) are removed by tingible body macrophages. There are several key differences between naive B cells and GC B cells, including level of proliferative activity, size, metabolic activity and energy production. The B cells develop dynamically after the activation of follicular B cells by T-dependent antigen. The initiation of germinal center formation involves the interaction between B and T cells in the interfollicular area of the lymph node, CD40-CD40L ligation, NF-kB signaling and expression of IRF4 and BCL6. GC B cells cycle through the two distinct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malaria
Malaria is a Mosquito-borne disease, mosquito-borne infectious disease that affects vertebrates and ''Anopheles'' mosquitoes. Human malaria causes Signs and symptoms, symptoms that typically include fever, Fatigue (medical), fatigue, vomiting, and headaches. In severe cases, it can cause jaundice, Epileptic seizure, seizures, coma, or death. Symptoms usually begin 10 to 15 days after being bitten by an infected ''Anopheles'' mosquito. If not properly treated, people may have recurrences of the disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial Immunity (medical), resistance disappears over months to years if the person has no continuing exposure to malaria. The mosquitoes themselves are harmed by malaria, causing reduced lifespans in those infected by it. Malaria is caused by protozoa, single-celled microorganisms of the genus ''Plasmodium''. It is spread exclusively through bites of infected female ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Morphology (biology)
Morphology (from Ancient Greek μορφή (morphḗ) "form", and λόγος (lógos) "word, study, research") is the study of the form and structure of organisms and their specific structural features. This includes aspects of the outward appearance (shape, structure, color, pattern, size), as well as the form and structure of internal parts like bones and organs, i.e., anatomy. This is in contrast to physiology, which deals primarily with function. Morphology is a branch of life science dealing with the study of the overall structure of an organism or taxon and its component parts. History The etymology of the word "morphology" is from the Ancient Greek (), meaning "form", and (), meaning "word, study, research". While the concept of form in biology, opposed to function, dates back to Aristotle (see Aristotle's biology), the field of morphology was developed by Johann Wolfgang von Goethe (1790) and independently by the German anatomist and physiologist Karl Fried ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunophenotype
Immunophenotyping is a technique used to study the protein expressed by cells. This technique is commonly used in basic science research and laboratory diagnostic purpose. This can be done on tissue section (fresh or fixed tissue), cell suspension, etc. An example is the detection of tumor markers, such as in the diagnosis of leukemia. It involves the labelling of white blood cells with antibodies directed against surface proteins on their membrane. By choosing appropriate antibodies, the differentiation of leukemic cells can be accurately determined. The labelled cells are processed in a flow cytometer, a laser-based instrument capable of analyzing thousands of cells per second. The whole procedure can be performed on cells from the blood, bone marrow Bone marrow is a semi-solid biological tissue, tissue found within the Spongy bone, spongy (also known as cancellous) portions of bones. In birds and mammals, bone marrow is the primary site of new blood cell production (or ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brazil
Brazil, officially the Federative Republic of Brazil, is the largest country in South America. It is the world's List of countries and dependencies by area, fifth-largest country by area and the List of countries and dependencies by population, seventh-largest by population, with over 212 million people. The country is a federation composed of 26 Federative units of Brazil, states and a Federal District (Brazil), Federal District, which hosts the capital, Brasília. List of cities in Brazil by population, Its most populous city is São Paulo, followed by Rio de Janeiro. Brazil has the most Portuguese-speaking countries, Portuguese speakers in the world and is the only country in the Americas where Portuguese language, Portuguese is an Portuguese-speaking world, official language. Bounded by the Atlantic Ocean on the east, Brazil has a Coastline of Brazil, coastline of . Covering roughly half of South America's land area, it Borders of Brazil, borders all other countries and ter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Papua New Guinea
Papua New Guinea, officially the Independent State of Papua New Guinea, is an island country in Oceania that comprises the eastern half of the island of New Guinea and offshore islands in Melanesia, a region of the southwestern Pacific Ocean north of Australia. It has Indonesia–Papua New Guinea border, a land border with Indonesia to the west and neighbours Australia to the south and the Solomon Islands to the east. Its capital, on its southern coast, is Port Moresby. The country is the world's third largest list of island countries, island country, with an area of . The nation was split in the 1880s between German New Guinea in the North and the Territory of Papua, British Territory of Papua in the South, the latter of which was ceded to Australia in 1902. All of present-day Papua New Guinea came under Australian control following World War I, with the legally distinct Territory of New Guinea being established out of the former German colony as a League of Nations mandate. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haematology
Hematology ( spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood. It involves treating diseases that affect the production of blood and its components, such as blood cells, hemoglobin, blood proteins, bone marrow, platelets, blood vessels, spleen, and the mechanism of coagulation. Such diseases might include hemophilia, sickle cell anemia, blood clots (thrombus), other bleeding disorders, and blood cancers such as leukemia, multiple myeloma, and lymphoma. The laboratory analysis of blood is frequently performed by a medical technologist or medical laboratory scientist. Specialization Physicians specialized in hematology are known as hematologists or haematologists. Their routine work mainly includes the care and treatment of patients with hematological diseases, although some may also work at the hematology laboratory viewing blood films and bone marrow s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Facial Bones
The facial skeleton comprises the ''facial bones'' that may attach to build a portion of the skull. The remainder of the skull is the neurocranium. In human anatomy and development, the facial skeleton is sometimes called the ''membranous viscerocranium'', which comprises the human mandible, mandible and dermatocranium, dermatocranial elements that are not part of the braincase. Structure In the human skull, the facial skeleton consists of fourteen bones in the face: * Inferior turbinal (2) * Lacrimal bones (2) * Human mandible, Mandible * Maxilla (2) * Nasal bones (2) * Palatine bones (2) * Vomer * Zygomatic bones (2) Variations Elements of the ''cartilaginous viscerocranium'' (i.e., splanchnocranium, splanchnocranial elements), such as the hyoid bone, are sometimes considered part of the facial skeleton. The ethmoid bone (or a part of it) and also the sphenoid bone are sometimes included, but otherwise considered part of the neurocranium. Because the maxillary bones are fused, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abdomen
The abdomen (colloquially called the gut, belly, tummy, midriff, tucky, or stomach) is the front part of the torso between the thorax (chest) and pelvis in humans and in other vertebrates. The area occupied by the abdomen is called the abdominal cavity. In arthropods, it is the posterior (anatomy), posterior tagma (biology), tagma of the body; it follows the thorax or cephalothorax. In humans, the abdomen stretches from the thorax at the thoracic diaphragm to the pelvis at the pelvic brim. The pelvic brim stretches from the lumbosacral joint (the intervertebral disc between Lumbar vertebrae, L5 and Vertebra#Sacrum, S1) to the pubic symphysis and is the edge of the pelvic inlet. The space above this inlet and under the thoracic diaphragm is termed the abdominal cavity. The boundary of the abdominal cavity is the abdominal wall in the front and the peritoneal surface at the rear. In vertebrates, the abdomen is a large body cavity enclosed by the abdominal muscles, at the front an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
