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Aziz Sancar
Aziz Sancar (; born 8September 1946) is a Turkish molecular biologist specializing in DNA repair, cell cycle checkpoints, and circadian clock. In 2015, he was awarded the Nobel Prize in Chemistry along with Tomas Lindahl and Paul L. Modrich for their mechanistic studies of DNA repair. He has made contributions on photolyase and nucleotide excision repair in bacteria that have changed his field. Sancar is currently the Sarah Graham Kenan Professor of Biochemistry and Biophysics at the University of North Carolina School of Medicine and a member of the UNC Lineberger Comprehensive Cancer Center. He is the co-founder of the Aziz & Gwen Sancar Foundation, which is a non-profit organization to promote Turkish culture and to support Turkish students in the United States. Early life Aziz Sancar was born on 8 September 1946 to a lower-middle-class family in the Savur district of Mardin Province, southeastern Turkey. His oldest brother Kenan Sancar is a retired brigadier ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Savur
Savur (; ; ), meaning “mountain ridge” in Syriac and formerly known as Savor, is a municipality and Districts of Turkey, district of Mardin Province, Turkey. Its area is 962 km2, and its population is 24,821 (2022). Demographics According to the Armenian Patriarchate of Constantinople, 1,032 lived in Savur on the eve of World War I. They had one church and two schools. They were massacred during the Armenian genocide. The Agha Petros mentions an Assyrian population of 200. Today, the town is populated by Arabs, Assyrian people, Assyrians and Kurds. Politics In the 2019 Turkish local elections, local elections of March 2019, Gülistan Öncü of the pro-minority Peoples' Democratic Party (Turkey), HDP was elected mayor. On 15 November 2019, she was detained due to an investigation related to Terrorism in Turkey, terrorism. She was dismissed the following day, and Kaymakam, District Governor Bayram Türker was appointed as a trustee. Composition There are 41 maha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Circadian Clock
A circadian clock, or circadian oscillator, also known as one’s internal alarm clock is a biochemical oscillator that cycles with a stable phase and is synchronized with solar time. Such a clock's ''in vivo'' period is necessarily almost exactly 24 hours (the earth's current solar day). In most living organisms, internally synchronized circadian clocks make it possible for the organism to anticipate daily environmental changes corresponding with the day–night cycle and adjust its biology and behavior accordingly. The term circadian derives from the Latin ''circa'' (about) ''dies'' (a day), since when taken away from external cues (such as environmental light), they do not run to exactly 24 hours. Clocks in humans in a lab in constant low light, for example, will average about 24.2 hours per day, rather than 24 hours exactly. The normal body clock oscillates with an endogenous period of exactly 24 hours, it entrains, when it receives sufficient daily corrective signals from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Turkish Armed Forces
The Turkish Armed Forces (TAF; , TSK) are the armed forces, military forces of the Turkey, Republic of Turkey. The TAF consist of the Turkish Army, Land Forces, the Turkish Navy, Naval Forces and the Turkish Air Force, Air Forces. The Chief of the Turkish General Staff, Chief of the General Staff of the Turkish Armed Forces, General Staff is the Commander of the Armed Forces. In wartime, the Chief of the General Staff acts as the Commander-in-chief, Commander-in-Chief on behalf of the President of Turkey, President, who represents the Supreme Military Command of the TAF on behalf of the Grand National Assembly of Turkey. Coordinating the military relations of the TAF with other NATO member states and friendly states is the responsibility of the General Staff. The history of the Turkish Armed Forces began with its formation after the collapse of the Ottoman Empire. The Turkish military perceived itself as the guardian of Kemalism, the official state ideology, especially of its e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mardin Province
Mardin Province (; ; ; ) is a province and metropolitan municipality in Turkey. Its area is 8,780 km2, and its population is 870,374 (2022). The largest city in the province is Kızıltepe, while the capital Mardin is the second largest city. Districts Mardin Province is divided into 10 districts: * Artuklu * Dargeçit * Derik * Kızıltepe * Mazıdağı * Midyat * Nusaybin * Ömerli * Savur * Yeşilli Demographics Mardin Province is a linguistically, ethnically and religiously diverse province. The dominant ethnic groups are Arabs, Assyrians, and Kurds, of which Kurds constitute a majority. Other minor groups include Armenians, Chechens and Turks, while Jews lived in the area before migrating to Israel around 1948. The Chechens settled in the region during the Russo-Turkish War in 1877/1878. The distinctive Mhallami community also reside in the district. The province is considered part of Turkish Kurdistan. In 1990, it was estimated that Kurds const ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Turkish Culture
The culture of Turkey () or the Turkish culture () includes both the national culture and local cultures. Currently, Turkey has various local cultures. Things such as music, folk dance, or kebap variety may be used to identify a local area. Turkey also has a national culture, such as national sports leagues, music bands, film stars, and trends in fashion. After the establishment of the republic, Kemalism emphasized Turkish culture, attempted to make "Islam a matter of personal conviction", and pursued modernization. Literature Turkish literature is the collection of written and oral texts composed in the Turkish language, either in its Ottoman form or in less exclusively literary forms, such as that spoken in the Republic of Turkey today. Traditional examples for Turkish folk literature include stories of Karagöz and Hacivat, Keloğlan, İncili Çavuş and Nasreddin Hoca, as well as the works of folk poets such as Yunus Emre and Aşık Veysel. The ''Book of Dede ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of North Carolina School Of Medicine
A university () is an institution of tertiary education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase , which roughly means "community of teachers and scholars". Universities typically offer both undergraduate and postgraduate programs. The first universities in Europe were established by Catholic monks. The University of Bologna (), Italy, which was founded in 1088, is the first university in the sense of: *being a high degree-awarding institute. *using the word (which was coined at its foundation). *having independence from the ecclesiastic schools and issuing secular as well as non-secular degrees (with teaching conducted by both clergy and non-clergy): grammar, rhetoric, logic, theology, canon law and notarial law.Hunt Janin: "The university in medieval life, 1179–1499", McFarland, 2008, , p. 55f.de Ridder-Symoens, Hilde''A History of the University in Europe: Volume 1, Universities in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sarah Graham Kenan
Sarah Graham Kenan (February 17, 1876 – March 16, 1968) was an American heiress and philanthropist. She inherited a third of her sister's share of the Standard Oil fortune in 1917 and established the Sarah Graham Kenan Foundation. Through her foundation, Kenan contributed financially to various institutions including the Episcopal Diocese of East Carolina, the University of North Carolina, Duke University, Saint Mary's School, and the Duplin County Board of Education. Her home, located in the Market Street Mansion District in Wilmington, North Carolina, now serves as the official residence of the chancellor of the University of North Carolina at Wilmington. In 1930, through an endowment she made, the Southern Historical Collection was established at the University of North Carolina at Chapel Hill. Early life and family Sarah Graham Kenan was born on February 17, 1876, in Wilmington, North Carolina, to William Rand Kenan, Sr. and Mary Hargrave Kenan. Her father, a Civil War v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleotide Excision Repair
Nucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. Intercalation (biochemistry), intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize Base excision repair#Lesions processed by BER, specific non-bulky lesions in DNA, it can correct only damaged bases that are removed by Base excision repair#DNA glycosylases, specific glycosylases. Similarly, the MMR pathway only targets mismatched Watson-Crick base pairs. Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts — these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the damage leads to removal of a short single-stranded DNA s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Photolyase
Photolyases () are DNA repair enzymes that repair damage caused by exposure to ultraviolet light. These enzymes require visible light (from the violet/blue end of the spectrum) both for their own activation and for the actual DNA repair. The DNA repair mechanism involving photolyases is called photoreactivation. They mainly convert pyrimidine dimers into a normal pair of pyrimidine bases. Photo reactivation, the first DNA repair mechanism to be discovered, was described initially by Albert Kelner in 1949 and independently by Renato Dulbecco also in 1949. Function Photolyases bind complementary DNA strands and break certain types of pyrimidine dimers that arise when a pair of thymine or cytosine bases on the same strand of DNA become covalently linked. The bond length of this dimerization is shorter than the bond length of normal B-DNA structure which produces an incorrect template for replication and transcription. The more common covalent linkage involves the formation of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize
The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred Nobel, Alfred Nobel's death. The original Nobel Prizes covered five fields: Nobel Prize in Physics, physics, Nobel Prize in Chemistry, chemistry, Nobel Prize in Physiology or Medicine, physiology or medicine, Nobel Prize in Literature, literature, and Nobel Peace Prize, peace, specified in Nobel's will. A sixth prize, the Nobel Memorial Prize in Economic Sciences, Prize in Economic Sciences, was established in 1968 by Sveriges Riksbank (Sweden's central bank) in memory of Alfred Nobel. The Nobel Prizes are widely regarded as the most prestigious awards available in their respective fields.Nobel Prize#Shalev69, Shalev, p. 8. Except in extraordinary circumstances, such as war, all six prizes are given annually. Each recipient, known as a laur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
