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Anton Köllisch
Anton Köllisch (16 March 1888 – September 1916) was a German chemist who, whilst working at Darmstadt for pharmaceutical giant Merck, first described the synthesis of the chemical MDMA. Life and work In 1911, Köllisch published his doctoral dissertation on the topic of indole synthesis from hydrazones under Otto Diels at the University of Berlin. While at Merck, Dr Köllisch was involved in investigating syntheses for methylhydrastinine and hydrastinine. A procedural patent was filed on Christmas Eve 1912 relating to these syntheses, which mentioned MDMA without name as a chemical intermediate. He was killed in the First World War World War I or the First World War (28 July 1914 – 11 November 1918), also known as the Great War, was a World war, global conflict between two coalitions: the Allies of World War I, Allies (or Entente) and the Central Powers. Fighting to .... References Bibliography * Germany, Kaiserliches Patentamt, Patentschrift Nr 274350, h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Darmstadt
Darmstadt () is a city in the States of Germany, state of Hesse in Germany, located in the southern part of the Frankfurt Rhine Main Area, Rhine-Main-Area (Frankfurt Metropolitan Region). Darmstadt has around 160,000 inhabitants, making it the fourth largest city in the state of Hesse after Frankfurt am Main, Wiesbaden, and Kassel. Darmstadt holds the official title "City of Science" () as it is a major centre of scientific institutions, universities, and high-technology companies. The European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT) and the European Space Agency's European Space Operations Centre (ESA ESOC) are located in Darmstadt, as well as Gesellschaft für Schwerionenforschung, GSI Centre for Heavy Ion Research, where several chemical elements such as bohrium (1981), meitnerium (1982), hassium (1984), darmstadtium (1994), roentgenium (1994), and copernicium (1996) were discovered. The existence of the following elements was also confirmed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Merck KGaA
The Merck Group, branded and commonly known as Merck, is a German Multinational corporation, multinational science and technology company headquartered in Darmstadt, with about 60,000 employees and a presence in 66 countries. The group includes around 250 companies; the main company is Merck KGaA in Germany. The company is divided into three business lines: Healthcare, Life Sciences and Electronics. Merck was founded in 1668 and is the world's oldest operating chemical and pharmaceutical company, as well as one of the largest pharmaceutical companies globally. Merck operates in Europe, Africa, Asia, Oceania and the Americas. It has major research and development centres in Darmstadt, Boston, Tokyo and Beijing, as well as other Research and Development units in Taiwan, France, Israel, South Korea, India, and the UK. Merck pioneered the commercial manufacture of morphine in the 19th century and for a time held a virtual monopoly on cocaine. Merck was privately owned until going ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MDMA
3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy (tablet form), and molly (crystal form), is an empathogen–entactogenic drug with stimulant and minor Psychedelic drug, psychedelic properties. In studies, it has been used alongside psychotherapy in the treatment of post-traumatic stress disorder (PTSD) and social anxiety in Autism, autism spectrum disorder. The purported pharmacological effects that may be Prosocial behavior, prosocial include altered sensations, increased energy, empathy, and pleasure. When taken by mouth, effects begin in 30 to 45 minutes and last three to six hours. MDMA was first synthesized in 1912 by Merck Group, Merck chemist Anton Köllisch. It was used to enhance psychotherapy beginning in the 1970s and became popular as a street drug in the 1980s. MDMA is commonly associated with dance party, dance parties, raves, and electronic dance music. Tablets sold as ecstasy may be Cutting agent, mixed with other substances such as ephedr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indole
Indole is an organic compound with the formula . Indole is classified as an aromatic heterocycle. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indoles are derivatives of indole where one or more of the hydrogen atoms have been replaced by substituent groups. Indoles are widely distributed in nature, most notably as amino acid tryptophan and neurotransmitter serotonin. General properties and occurrence Indole is a solid at room temperature. It occurs naturally in human feces and has an intense fecal odor. At very low concentrations, however, it has a flowery smell, and is a constituent of many perfumes. It also occurs in coal tar. It has been identified in cannabis. It is the main volatile compound in stinky tofu. When indole is a substituent on a larger molecule, it is called an ''indolyl group'' by systematic nomenclature. Indole undergoes electrophilic substitution, mainly at position 3 (see diagram in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrazone
Hydrazones are a class of organic compounds with the structure . They are related to ketones and aldehydes by the replacement of the oxygen =O with the = functional group. They are formed usually by the action of hydrazine on ketones or aldehydes. Synthesis Hydrazine, organohydrazines, and 1,1-diorganohydrazines react with aldehydes and ketones to give hydrazones. : Phenylhydrazine reacts with reducing sugars to form hydrazones known as osazones, which was developed by German chemist Emil Fischer as a test to differentiate monosaccharides. Uses image:Pigment Yellow 97.svg, left, Pigment Yellow 97, a popular yellow colorant, is a hydrazone., 160px Hydrazones are the basis for various analyses of ketones and aldehydes. For example, dinitrophenylhydrazine coated onto a silica sorbent is the basis of an adsorption cartridge. The hydrazones are then eluted and analyzed by high-performance liquid chromatography (HPLC) using a ultraviolet, UV detector. The compound carbonyl cyanide-p-t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Otto Diels
Otto Paul Hermann Diels (; 23 January 1876 – 7 March 1954) was a German chemist. His most notable work was done with Kurt Alder on the Diels–Alder reaction, a method for cyclohexene synthesis. The pair was awarded the Nobel Prize in Chemistry in 1950 for their work. Their method of synthesizing cyclic organic compounds proved valuable for the manufacture of synthetic rubber and plastic. He completed his education at the University of Berlin, where he later worked. Diels was employed at the University of Kiel when he completed his Nobel Prize-winning work, and remained there until he retired in 1945. Diels was married, with five children. He died in 1954. Early life Diels was born on 23 January 1876 in Hamburg, Germany, and moved with his family to Berlin when he was two years old. He studied in Berlin at Joachimsthalsches Gymnasium before attending the University of Berlin starting in 1895. While at university, Diels studied chemistry under Emil Fischer, eventu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Berlin
The Humboldt University of Berlin (, abbreviated HU Berlin) is a public research university in the central borough of Mitte in Berlin, Germany. The university was established by Frederick William III on the initiative of Wilhelm von Humboldt, Johann Gottlieb Fichte and Friedrich Daniel Ernst Schleiermacher as the University of Berlin () in 1809, and opened in 1810. From 1828 until its closure in 1945, it was named the (Royal) Friedrich Wilhelm University of Berlin (FWU Berlin; ). During the Cold War, the university found itself in East Berlin and was ''de facto'' split in two when the Free University of Berlin opened in West Berlin. The university received its current name in honour of Alexander and Wilhelm von Humboldt in 1949. The university is divided into nine faculties including its medical school shared with the Freie Universität Berlin. The university has a student enrollment of around 35,000 students, and offers degree programs in some 171 disciplines from und ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anton Köllisch
Anton Köllisch (16 March 1888 – September 1916) was a German chemist who, whilst working at Darmstadt for pharmaceutical giant Merck, first described the synthesis of the chemical MDMA. Life and work In 1911, Köllisch published his doctoral dissertation on the topic of indole synthesis from hydrazones under Otto Diels at the University of Berlin. While at Merck, Dr Köllisch was involved in investigating syntheses for methylhydrastinine and hydrastinine. A procedural patent was filed on Christmas Eve 1912 relating to these syntheses, which mentioned MDMA without name as a chemical intermediate. He was killed in the First World War World War I or the First World War (28 July 1914 – 11 November 1918), also known as the Great War, was a World war, global conflict between two coalitions: the Allies of World War I, Allies (or Entente) and the Central Powers. Fighting to .... References Bibliography * Germany, Kaiserliches Patentamt, Patentschrift Nr 274350, h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrastinine
Hydrastinine is a semisynthetic tetrahydroisoquinoline alkaloid made via the nitric acid induced hydrolysis of the alkaloid hydrastine hydrochloride, which is extracted from ''Hydrastis canadensis'' L. (Ranunculaceae). The drug was patented by Bayer as a haemostatic drug during the 1910s. The first known synthesis of methylenedioxymethamphetamine (MDMA) was actually an intermediate in the synthesis of the methylated analogue of hydrastinine, methylhydrastinine. It was only reviewed for its activity many years after its original synthesis. Hydrastinine has also been found as a major unwanted side product in MDMA made by the reductive amination Reductive amination (also known as reductive alkylation) is a form of amination that converts a carbonyl group to an amine via an intermediate imine. The carbonyl group is most commonly a ketone or an aldehyde. It is a common method to make amine ... of 3,4-methylenedioxyphenylpropan-2-one and methylamine. See also * Substituted tetr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Christmas Eve
Christmas Eve is the evening or entire day before Christmas, the festival commemorating nativity of Jesus, the birth of Jesus in Christianity, Jesus. Christmas Day is observance of Christmas by country, observed around the world, and Christmas Eve is widely observed as a full or partial holiday in anticipation of Christmas Day. Together, both days are considered one of the most culturally significant celebrations in Christendom and Western world, Western society. Christmas celebrations in the Christian denomination, denominations of Western Christianity have long begun on Christmas Eve, due in part to the Christian liturgical day starting at sunset, a practice inherited from Jewish tradition, and based on the Genesis creation narrative, story of Creation in the Book of Genesis: "And there was evening, and there was morning—the first day." Many churches still ring their church bells and hold Christian prayer, prayers in the evening; for example, the Nordic Lutheran churches. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
First World War
World War I or the First World War (28 July 1914 – 11 November 1918), also known as the Great War, was a World war, global conflict between two coalitions: the Allies of World War I, Allies (or Entente) and the Central Powers. Fighting took place mainly in European theatre of World War I, Europe and the Middle Eastern theatre of World War I, Middle East, as well as in parts of African theatre of World War I, Africa and the Asian and Pacific theatre of World War I, Asia-Pacific, and in Europe was characterised by trench warfare; the widespread use of Artillery of World War I, artillery, machine guns, and Chemical weapons in World War I, chemical weapons (gas); and the introductions of Tanks in World War I, tanks and Aviation in World War I, aircraft. World War I was one of the List of wars by death toll, deadliest conflicts in history, resulting in an estimated World War I casualties, 10 million military dead and more than 20 million wounded, plus some 10 million civilian de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guardian Unlimited
''The Guardian'' is a British daily newspaper. It was founded in Manchester in 1821 as ''The Manchester Guardian'' and changed its name in 1959, followed by a move to London. Along with its sister paper, ''The Guardian Weekly'', ''The Guardian'' is part of the Guardian Media Group, owned by the Scott Trust Limited. The trust was created in 1936 to "secure the financial and editorial independence of ''The Guardian'' in perpetuity and to safeguard the journalistic freedom and liberal values of ''The Guardian'' free from commercial or political interference". The trust was converted into a limited company in 2008, with a constitution written so as to maintain for ''The Guardian'' the same protections as were built into the structure of the Scott Trust by its creators. Profits are reinvested in its journalism rather than distributed to owners or shareholders. It is considered a newspaper of record in the UK. The editor-in-chief Katharine Viner succeeded Alan Rusbridger in 2015. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
