|
Annonacin
Annonacin is a chemical compound with toxic effects, especially in the nervous system, found in some fruits such as the paw paw, custard apples, soursop, and others from the family ''Annonaceae''. It is a member of the class of compounds known as acetogenins. Annonacin-containing fruit products are regularly consumed throughout the West Indies for their traditional medicine uses. Traditional medicine Historically, plants and fruits of Annonaceae (particularly ''Annona muricata'' and '' Annona squamosa'') have been consumed in various forms throughout the West Indies, usually as hot water extracts of leaves.Ross, I. A. (2003). Annona muricata L. Medicinal Plants of the World, Vol. 1: Chemical Constituents, Traditional and Modern Medicinal Uses,1, 133-142. These annonacin-containing herbal teas are thought to be useful in folk medicine. On the Caribbean island of Guadeloupe, such teas are consumed mainly for their sedative qualities. Use of annonacin products in Guadeloupe ofte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Soursop Fruit
Soursop (also called graviola, guyabano, and in Latin America ) is the fruit of ''Annona muricata'', a broadleaf, flowering, evergreen tree. It is native to the tropical regions of the Americas and the Caribbean and is widely propagated. It is in the same genus, ''Annona'', as cherimoya and is in the Annonaceae family. The soursop is adapted to areas of high humidity and relatively warm winters; temperatures below will cause damage to leaves and small branches, and temperatures below can be fatal. The fruit becomes dry and is no longer good for concentrate. With an aroma similar to pineapple, the flavor of the fruit has been described as a combination of strawberries and apple with sour citrus flavor notes, contrasting with an underlying thick creamy texture reminiscent of banana. Soursop is widely promoted (sometimes as graviola) as an alternative cancer treatment, but there is no reliable medical evidence that it is effective for treating cancer or any disease. Sours ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Soursop
Soursop (also called graviola, guyabano, and in Latin America ) is the fruit of ''Annona muricata'', a broadleaf, flowering, evergreen tree. It is native to the Tropics, tropical regions of the Americas and the Caribbean and is widely propagated. It is in the same genus, ''Annona'', as cherimoya and is in the Annonaceae family. The soursop is adapted to areas of high humidity and relatively warm winters; temperatures below will cause damage to leaves and small branches, and temperatures below can be fatal. The fruit becomes dry and is no longer good for concentrate. With an aroma similar to pineapple, the flavor of the fruit has been described as a combination of strawberries and apple with sour citrus flavor notes, contrasting with an underlying thick creamy texture reminiscent of banana. Soursop is widely promoted (sometimes as graviola) as an Alternative cancer treatments, alternative cancer treatment, but there is no reliable evidence-based medicine, medical evidence ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Annona Muricata
Soursop (also called graviola, guyabano, and in Latin America ) is the fruit of ''Annona muricata'', a broadleaf, flowering, evergreen tree. It is native to the tropical regions of the Americas and the Caribbean and is widely propagated. It is in the same genus, '' Annona'', as cherimoya and is in the Annonaceae family. The soursop is adapted to areas of high humidity and relatively warm winters; temperatures below will cause damage to leaves and small branches, and temperatures below can be fatal. The fruit becomes dry and is no longer good for concentrate. With an aroma similar to pineapple, the flavor of the fruit has been described as a combination of strawberries and apple with sour citrus flavor notes, contrasting with an underlying thick creamy texture reminiscent of banana. Soursop is widely promoted (sometimes as graviola) as an alternative cancer treatment, but there is no reliable medical evidence that it is effective for treating cancer or any disease. S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Asimina Triloba
''Asimina triloba'', the American papaw, pawpaw, paw paw, or paw-paw, among many regional names, is a small deciduous tree native to the eastern United States and southern Ontario, Canada, producing a large, yellowish-green to brown fruit. ''Asimina'' is the only temperate genus in the tropical and subtropical flowering plant family Annonaceae, and ''Asimina triloba'' has the most northern range of all. Well-known tropical fruits of different genera in family Annonaceae include the custard-apple, cherimoya, Sugar-apple, sweetsop, Cananga odorata, ylang-ylang, and soursop. The pawpaw is a cloning, patch-forming (clonal) understory tree of hardwood forests, which is found in well-drained, deep, fertile bottomland and also hilly upland habitat. It has large, simple leaves with drip tips, more characteristic of plants in tropical rainforests than within this species' temperate climate, temperate range. Pawpaw fruits are the second largest edible fruit Indigenous (ecology), indigenou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Annonaceae
The Annonaceae are a Family (biology), family of flowering plants consisting of trees, shrubs, or rarely lianas commonly known as the custard apple family or soursop family. With 108 accepted genera and about 2400 known species, it is the largest family in the Magnoliales. Several genera produce edible fruit, most notably ''Annona'', ''Anonidium'', ''Asimina'', ''Rollinia'', and ''Uvaria''. Its type genus is ''Annona''. The family is concentrated in the tropics, with few species found in temperate regions. About 900 species are Neotropical, 450 are Afrotropical, and the remaining are Indomalayan. Description The species are mostly tropical, some are mid-latitude, deciduous or evergreen trees and shrubs, with some lianas, with aromatic bark, leaves, and flowers. ; Stems, stalks and leaves: Bark is fibrous and aromatic. Pith septate (fine tangential bands divided by partitions) to diaphragmed (divided by thin partitions with openings in them). Branching distichous (arranged in two ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetogenin
Acetogenins are a class of polyketide natural products found in plants of the family Annonaceae. They are characterized by linear 32- or 34-carbon chains containing oxygenated functional groups including hydroxyls, ketones, epoxides, tetrahydrofurans and tetrahydropyrans. They are often terminated with a lactone or butenolide. Over 400 members of this family of compounds have been isolated from 51 different species of plants. Many acetogenins are characterized by neurotoxicity. Examples include: * Annonacin * Annonins * Bullatacin * Uvaricin Structure Structurally, acetogenins are a series of C-35/C-37 compounds usually characterized by a long aliphatic chain bearing a terminal methyl-substituted α,β-unsaturated γ-lactone ring, as well as one to three tetrahydrofuran ( THF) rings. These THF rings are located along the hydrocarbon chain, along with a number of oxygenated moieties (hydroxyls, acetoxyls, ketones, epoxides) and/or double bonds. Research Ac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polyketides
In organic chemistry, polyketides are a class of natural products derived from a precursor molecule consisting of a chain of alternating ketone (, or its reduced forms) and methylene () groups: . First studied in the early 20th century, discovery, biosynthesis, and application of polyketides has evolved. It is a large and diverse group of secondary metabolites caused by its complex biosynthesis which resembles that of fatty acid synthesis. Because of this diversity, polyketides can have various medicinal, agricultural, and industrial applications. Many polyketides are medicinal or exhibit acute toxicity. Biotechnology has enabled discovery of more naturally-occurring polyketides and evolution of new polyketides with novel or improved bioactivity. History Naturally produced polyketides by various plants and organisms have been used by humans since before studies on them began in the 19th and 20th century. In 1893, J. Norman Collie synthesized detectable amounts of orcinol by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Progressive Supranuclear Palsy
Progressive supranuclear palsy (PSP) is a late-onset neurodegenerative disease involving the gradual deterioration and death of specific volumes of the brain, linked to 4-repeat tau pathology. The condition leads to symptoms including Balance disorder, loss of balance, Hypokinesia, slowing of movement, Ophthalmoparesis, difficulty moving the eyes, and cognitive impairment. PSP may be mistaken for other types of neurodegeneration such as Parkinson's disease, frontotemporal dementia and Alzheimer's disease. It is the second most common tauopathy behind Alzheimer's disease. The cause of the condition is uncertain, but involves the accumulation of tau protein within the brain. Medications such as L-DOPA, levodopa and amantadine may be useful in some cases. PSP was first officially described by Richardson, Steele, and Olszewski in 1963 as a form of progressive parkinsonism. However, the earliest known case presenting clinical features consistent with PSP, along with pathological co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Complex I
Respiratory complex I, (also known as NADH:ubiquinone oxidoreductase, Type I NADH dehydrogenase and mitochondrial complex I) is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocates protons across the inner mitochondrial membrane in eukaryotes or the plasma membrane of bacteria. This enzyme is essential for the normal functioning of cells, and mutations in its subunits lead to a wide range of inherited neuromuscular and metabolic disorders. Defects in this enzyme are responsible for the development of several pathological processes such as ischemia/reperfusion damage (stroke and cardiac infarction), Parkinson's disease and others. Function Complex I is the first enzyme of the mitochondrial electron transport chain. There are three energy-transducing enzymes in the electron transport chain - NADH:ubiquinone oxidoreductase (comp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basal Ganglia
The basal ganglia (BG) or basal nuclei are a group of subcortical Nucleus (neuroanatomy), nuclei found in the brains of vertebrates. In humans and other primates, differences exist, primarily in the division of the globus pallidus into external and internal regions, and in the division of the striatum. Positioned at the base of the forebrain and the top of the midbrain, they have strong connections with the cerebral cortex, thalamus, brainstem and other brain areas. The basal ganglia are associated with a variety of functions, including regulating voluntary motor control, motor movements, procedural memory, procedural learning, habituation, habit formation, conditional learning, eye movements, cognition, and emotion. The main functional components of the basal ganglia include the striatum, consisting of both the dorsal striatum (caudate nucleus and putamen) and the ventral striatum (nucleus accumbens and olfactory tubercle), the globus pallidus, the ventral pallidum, the substa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brainstem
The brainstem (or brain stem) is the posterior stalk-like part of the brain that connects the cerebrum with the spinal cord. In the human brain the brainstem is composed of the midbrain, the pons, and the medulla oblongata. The midbrain is continuous with the thalamus of the diencephalon through the tentorial notch, and sometimes the diencephalon is included in the brainstem. The brainstem is very small, making up around only 2.6 percent of the brain's total weight. It has the critical roles of regulating heart and respiratory system, respiratory function, helping to control heart rate and breathing rate. It also provides the main motor and sensory nerve supply to the face and neck via the cranial nerves. Ten pairs of cranial nerves come from the brainstem. Other roles include the regulation of the central nervous system and the body's sleep cycle. It is also of prime importance in the conveyance of motor and sensory pathways from the rest of the brain to the body, and from the b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxicity
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacteria, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (biology), cell (cytotoxicity) or an organ such as the liver (hepatotoxicity). Sometimes the word is more or less synonymous with poison#Poisoning, poisoning in everyday usage. A central concept of toxicology is that the effects of a toxicant are Dose (biochemistry), dose-dependent; even water can lead to water intoxication when taken in too high a dose, whereas for even a very toxic substance such as snake venom there is a dose below which there is no detectable toxic effect. Toxicity is species-specific, making cross-species analysis problematic. Newer paradigms and metrics are evolving to bypass animal testing, while maintaining the concept of toxicity endpoints. Etymology In Ancient G ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
