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Alfred Tissières
Alfred Tissières (October 14, 1917 – June 7, 2003) was a Swiss molecular biologist, a pioneer in highlighting the role of ribosomes in protein biosynthesis and the initiator of studies on heat shock proteins synthesized by cells subjected to stress. He shared the Marcel Benoist Prize with Edouard Kellenberger in 1966. Early life and education Tissières was born on October 14, 1917 in Martigny. He comes from the neighboring town of Orsières. After studying medicine in Lausanne, where he obtained a doctorate in 1946, Tissières left to do a PhD in England at Cambridge, at the Molteno Institute for Research in Parasitology in the laboratory of David Keilin. Professional and scientific career From 1951 to 1952, he carried out a postdoctoral internship in the laboratory of Max Delbrück at the California Institute of Technology. He worked there on the respiration of enterobacteria with Herschel K. Mitchell. In 1953 he returned to Cambridge as a research fellow at King's Coll ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Martigny
Martigny (; , ; ) is the capital city of the district of Martigny (district), Martigny, cantons of Switzerland, canton of Canton of Valais, Valais, Switzerland. It lies at an elevation of , and its population is approximately 20,000 inhabitants (''Martignerains'' or "Octoduriens"). It is a junction of roads joining Italy, France and Switzerland. One road links it over the Great St. Bernard Pass to Aosta (Italy), and the other over the col de la Forclaz to Chamonix (France). In winter, Martigny is known for its numerous nearby Alp ski resorts such as Verbier. Geography Martigny lies at an elevation of , about south-southeast of Montreux. It is on the left foothills of the steep hillsides of the Rhone Valley, at the foot of the Swiss Alps, and is located at the point where the southwestern-flowing Rhone turns ninety degrees northward and heads toward Lake Geneva. The river La Drance flows from the southern Valais Alps (Wallis) through Martigny and joins the Rhone from the left just ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heat Shock Proteins
Heat shock proteins (HSPs) are a family of proteins produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins are named according to their molecular weight. For example, Hsp60, Hsp70 and Hsp90 (the most widely studied HSPs) refer to families of heat shock proteins on the order of 60, 70 and 90 kilod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chaperone (protein)
In molecular biology, molecular chaperones are proteins that assist the conformational folding or unfolding of large proteins or macromolecular protein complexes. There are a number of classes of molecular chaperones, all of which function to assist large proteins in proper protein folding during or after synthesis, and after partial denaturation. Chaperones are also involved in the translocation of proteins for proteolysis. The first molecular chaperones discovered were a type of assembly chaperones which assist in the assembly of nucleosomes from folded histones and DNA. One major function of molecular chaperones is to prevent the aggregation of misfolded proteins, thus many chaperone proteins are classified as heat shock proteins, as the tendency for protein aggregation is increased by heat stress. The majority of molecular chaperones do not convey any steric information for protein folding, and instead assist in protein folding by binding to and stabilizing folding intermedi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ferruccio Ritossa
Ferruccio Ritossa (February 25, 1936 – January 9, 2014) was an Italian geneticist best known for his discovery of the heat shock response in the model organism '' Drosophila'' (fruit flies). Early life and education Ritossa was born in the town of Pinguente in Istria in 1936, one of three sons. His father, a butcher, was killed in the foibe killings when Ritossa was a young child. His mother moved the family to Italy and taught school in an orphanage, where her three children were also educated. Ritossa attended the University of Bologna to study agricultural sciences and graduated in 1958. He became interested in genetics, particularly in then-emerging molecular studies of the field, and joined a newly established course in biophysics taught by Adriano Buzzati-Traverso at the University of Pavia, where Buzzati-Traverso had begun to establish '' Drosophila'' research and collections. Buzzati-Traverso founded a laboratory, now the Istituto di Genetica e Biofisica, in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marshall Warren Nirenberg
Marshall Warren Nirenberg (April 10, 1927 – January 15, 2010) was an American biochemist and geneticist. He shared a Nobel Prize in Physiology or Medicine in 1968 with Har Gobind Khorana and Robert W. Holley for "breaking the genetic code" and describing how it operates in protein synthesis. In the same year, together with Har Gobind Khorana, he was awarded the Louisa Gross Horwitz Prize from Columbia University. Biography Nirenberg was born in New York City to a Jewish family, the son of Minerva (Bykowsky) and Harry Edward Nirenberg, a shirtmaker. He developed rheumatic fever as a boy, so the family moved to Orlando, Florida to take advantage of the subtropical climate. He developed an early interest in biology. In 1948 he received his BS degree, and in 1952, a master's degree in zoology from the University of Florida at Gainesville where he was also a member of the Pi Lambda Phi Fraternity.Membership Directory, 2010, Pi Lambda Phi Inc. His dissertation for the Mas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard
Harvard University is a private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher learning in the United States. Its influence, wealth, and rankings have made it one of the most prestigious universities in the world. Harvard was founded and authorized by the Massachusetts General Court, the governing legislature of colonial-era Massachusetts Bay Colony. While never formally affiliated with any denomination, Harvard trained Congregational clergy until its curriculum and student body were gradually secularized in the 18th century. By the 19th century, Harvard emerged as the most prominent academic and cultural institution among the Boston elite. Following the American Civil War, under Harvard president Charles William Eliot's long tenure from 1869 to 1909, Harvard developed multiple professional schools, which transfo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jacques Monod
Jacques Lucien Monod (; 9 February 1910 – 31 May 1976) was a French biochemist who won the Nobel Prize in Physiology or Medicine in 1965, sharing it with François Jacob and André Lwoff "for their discoveries concerning genetic control of enzyme and virus synthesis".'' Chance and Necessity: An Essay on the Natural Philosophy of Modern Biology'' by Jacques Monod, New York, Alfred A. Knopf, 1971, Monod and Jacob became famous for their work on the '' E. coli'' ''lac'' operon, which encodes proteins necessary for the transport and breakdown of the sugar lactose (lac). From their own work and the work of others, they came up with a model for how the levels of some proteins in a cell are controlled. In their model, the manufacture of a set of related proteins, such as the ones encoded within the ''lac'' (lactose) operon, is prevented when a repressor protein, encoded by a regulatory gene, binds to its operator, a specific site in the DNA sequence that is close to the genes en ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Messenger RNAs
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein. mRNA is created during the process of Transcription (biology), transcription, where an enzyme (RNA polymerase) converts the gene into primary transcript mRNA (also known as pre-mRNA). This pre-mRNA usually still contains introns, regions that will not go on to code for the final amino acid sequence. These are removed in the process of RNA splicing, leaving only exons, regions that will encode the protein. This exon sequence constitutes mature mRNA. Mature mRNA is then read by the ribosome, and the ribosome creates the protein utilizing amino acids carried by transfer RNA (tRNA). This process is known as Translation (biology), translation. All of these processes form part of the central dogma of molecular biology, which describes the flow of geneti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
