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Albomycin δ2-iron Bound
Albomycins are a group of naturally occurring antibiotics belonging to the class of sideromycins, which are "compounds composed of iron carriers called siderophores linked to antibiotic moieties". They are particularly effective against Gram-negative bacteria of the family ''Enterobacteriaceae'' and few Gram-positive bacteria such s ''Streptococcus pneumoniae'', ''Bacillus subtilis'' and ''Staphylococcus aureus''. In 2000 a group of scientists from SmithKline Beecham Pharmaceuticals, UK reported that the antibiotic part of albomycin ''in vitro'' can inhibit seryl-tRNA synthetase from both eukaryotic and prokaryotic representatives. Structure Albomycins are naturally occurring sideromycins produced by some streptomycetes. The siderophore part of albomycin δ2 is similar to ferrichrome. It contains three molecules of δ-N-hydroxy-δ-N-acetyl ornithine linked to a serine, all by peptide linkage. The C-terminus of the serine is linked to another serine attached to the antibiotica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Bacteriology
A journal, from the Old French ''journal'' (meaning "daily"), may refer to: *Bullet journal, a method of personal organization *Diary, a record of personal secretive thoughts and as open book to personal therapy or used to feel connected to oneself. A record of what happened over the course of a day or other period *Daybook, also known as a general journal, a daily record of financial transactions *Logbook, a record of events important to the operation of a vehicle, facility, or otherwise * Transaction log, a chronological record of data processing * Travel journal, a record of the traveller's experience during the course of their journey In publishing, ''journal'' can refer to various periodicals or serials: *Academic journal, an academic or scholarly periodical **Scientific journal, an academic journal focusing on science ** Medical journal, an academic journal focusing on medicine **Law review, a professional journal focusing on legal interpretation *Magazine, non-academic or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Journal Of Biochemistry
''The FEBS Journal'' is a biweekly peer-reviewed scientific journal published by John Wiley & Sons on behalf of the Federation of European Biochemical Societies. It covers research on all aspects of biochemistry, molecular biology, cell biology, and the molecular bases of disease. The editor-in-chief is Seamus Martin (Trinity College Dublin), who took over from Richard Perham (University of Cambridge) in 2014. Content is available for free 1 year after publication, except review content, which is available immediately. The journal also publishes special and virtual issues focusing on a specific theme. Since 2021, the journal has given an annual award, "The FEBS Journal Richard Perham Prize", for an outstanding research paper published in the journal. The winners receive a €5,000 cash prize (to be divided equally between the first and last authors) and the senior author of the study is invited to give a talk at the FEBS Annual Congress. The journal also gives more frequent pos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytidine
Cytidine (symbol C or Cyd) is a nucleoside molecule that is formed when cytosine is attached to a ribose ring (also known as a ribofuranose) via a β-N1-glycosidic bond. Cytidine is a component of RNA. It is a white water-soluble solid that is only slightly soluble in ethanol. Dietary sources Dietary sources of cytidine include foods with high RNA (ribonucleic acid) content, such as organ meats, brewer's yeast, as well as pyrimidine-rich foods such as beer. During digestion, RNA-rich foods are broken-down into ribosyl pyrimidines (cytidine and uridine), which are absorbed intact. In humans, dietary cytidine is converted into uridine, which is probably the compound behind cytidine's metabolic effects. Cytidine analogues A variety of cytidine analogues are known, some with potentially useful pharmacology. For example, KP-1461 is an anti-HIV agent that works as a viral mutagen, and zebularine exists in '' E. coli'' and is being examined for chemotherapy. Low doses of azacit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serine
Serine (symbol Ser or S) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α- amino group (which is in the protonated − form under biological conditions), a carboxyl group (which is in the deprotonated − form under biological conditions), and a side chain consisting of a hydroxymethyl group, classifying it as a polar amino acid. It can be synthesized in the human body under normal physiological circumstances, making it a nonessential amino acid. It is encoded by the codons UCU, UCC, UCA, UCG, AGU and AGC. Occurrence This compound is one of the proteinogenic amino acids. Only the L- stereoisomer appears naturally in proteins. It is not essential to the human diet, since it is synthesized in the body from other metabolites, including glycine. Serine was first obtained from silk protein, a particularly rich source, in 1865 by Emil Cramer. Its name is derived from the Latin for silk, '' sericum''. Serine's structure was established in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ornithine
Ornithine is a non-proteinogenic α-amino acid that plays a role in the urea cycle. It is not incorporated into proteins during translation. Ornithine is abnormally accumulated in the body in ornithine transcarbamylase deficiency, a disorder of the urea cycle. The Moiety (chemistry), moiety derived from ornithine is called ornithyl. Role in urea cycle L-Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea. Therefore, ornithine is a central component of the urea cycle, which enables the disposal of excess nitrogen. Ornithine itself is recycled and, in a sense, acts as a catalyst. First, ammonia is converted into carbamoyl phosphate () by carbamoyl phosphate synthetase. Ornithine transcarbamylase then catalyzes the reaction between carbamoyl phosphate and ornithine to form citrulline and phosphate (Pi). Another amino group is contributed by aspartate, leading to the formation of arginine and the byproduct fumarate. The resulting arginine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ferrichrome
Ferrichrome is a cyclic hexa-peptide that forms a complex with iron atoms. It is a siderophore composed of three glycine and three modified ornithine residues with hydroxamate groups N(OH)C(=O)C- The 6 oxygen atoms from the three hydroxamate groups bind Fe(III) in near perfect octahedral coordination. Ferrichrome was first isolated in 1952, and has been found to be produced by fungi of the genera ''Aspergillus'', '' Ustilago'', and ''Penicillium''. However, at the time there was no understanding regarding its involvement and contribution to iron transport. It was not until 1957 because of Joe Neilands' work, where he first noted that Ferrichrome was able to act as an iron transport agent. Biological function Ferrichrome is a siderophore, which are metal chelating agents that have a low molecular mass and are produced by microorganisms and plants growing under low iron conditions. The main function of siderophores is to chelate ferric iron (Fe3+) from insoluble minerals from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptomycete
Streptomycetaceae is a family of the order Streptomycetales. It includes the important genus ''Streptomyces''. This was the original source of many antibiotics, namely streptomycin, the first antibiotic against tuberculosis. Genomics Sequence alignments of actinomycetotal genomes have led to the identification of three conserved signature indels which are unique to the order Streptomycetales. The enzyme PBGD contains a four-amino-acid insertion which is present in all ''Streptomyces'' species and ''Kitasatospora setae'', but not any other Actinomycetota. Similarly, a one- amino-acid insertion is present in a conserved region of adenylate kinase and is found in all ''Streptomyces'' species and '' K. setae'', but is not found in any other Actinomycetota. Five conserved signature proteins have also been identified which are present in various sequenced ''Streptomyces'' species, but not in ''K. setae''; however, as the complete genome of ''K. setae'' has not yet been sequenced, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Journal Of Antibiotics
''The Journal of Antibiotics'' is a peer-reviewed medical journal published by the Nature Publishing Group for the Japan Antibiotics Research Association. The journal seeks to endorse studies on antibiotics and associated types of biologically-active substances. In June 2020, the journal published a pioneer systematic review on ivermectin and COVID-19 by Fatemeh Heiday and Reza Gharebaghi which has become highly cited. Abstracting and indexing The journal is abstracted and indexed for example in: According to the ''Journal Citation Reports'', the journal has a 2022 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a type of journal ranking. Journals with higher impact factor values are considered more prestigious or important within their field. The Impact Factor of a journa ... of 3.3. References External links * Microbiology journals Nature Research academic journals Monthly journals Academic journals establish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Journal Of Medical Microbiology
The ''International Journal of Medical Microbiology'', formerly the ''Zentralblatt für Bakteriologie'', is a peer-reviewed medical journal covering research on microbiology published by Elsevier. It was established in 1887 by Friedrich Loeffler. The current editor-in-chief is Sebastian Suerbaum (Max von Pettenkofer-Institut). According to the ''Journal Citation Reports'', the journal has a 2022 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a type of journal ranking. Journals with higher impact factor values are considered more prestigious or important within their field. The Impact Factor of a journa ... of 4.1. References External links * {{Official website, http://www.elsevier.com/wps/find/journaldescription.cws_home/701772/description#description Microbiology journals Elsevier academic journals Publications established in 1887 English-language journals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
