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Adrian Krainer (scientist)
Adrian Robert Krainer is a Uruguayan-American biochemist and molecular geneticist known for his research into RNA gene-splicing. He helped create a drug for patients with spinal muscular atrophy. Krainer holds the St. Giles Foundation Professorship at Cold Spring Harbor Laboratory in Laurel Hollow, New York. Early life and education Krainer was born in Montevideo, Uruguay to a Jewish family of Hungarian and Romanian descent. He has one older brother, who is a chemical engineer. His father did forced labor for two years in a Romanian labor camp (Ferma Alba) during World War II. After the war, his father's original surname, Kreiner changed to Krainer due to a clerical error when he was a refugee in Italy. His parents owned a small leather business in Montevideo. Krainer attended a private bilingual French-Spanish elementary school. He later attended a public school for two years before completing his pre-college education with four years at a private Spanish-Hebrew school. Kr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Montevideo
Montevideo (, ; ) is the capital city, capital and List of cities in Uruguay, largest city of Uruguay. According to the 2023 census, the city proper has a population of 1,302,954 (about 37.2% of the country's total population) in an area of . Montevideo is situated on the southern coast of the country, on the northeastern bank of the Río de la Plata. A Portuguese garrison was established in the place where today is the city of Montevideo in November 1723. The Portuguese garrison was expelled in February 1724 by a Spanish soldier, Bruno Mauricio de Zabala, as a strategic move amidst the Spanish people, Spanish-Portuguese people, Portuguese dispute over the Río de la Plata Basin, platine region. There is no official document establishing the foundation of the city, but the "Diario" of Bruno Mauricio de Zabala officially mentions the date of 24 December 1726 as the foundation, corroborated by presential witnesses. The complete independence from Buenos Aires as a real city was not ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Italy
Italy, officially the Italian Republic, is a country in Southern Europe, Southern and Western Europe, Western Europe. It consists of Italian Peninsula, a peninsula that extends into the Mediterranean Sea, with the Alps on its northern land border, as well as List of islands of Italy, nearly 800 islands, notably Sicily and Sardinia. Italy shares land borders with France to the west; Switzerland and Austria to the north; Slovenia to the east; and the two enclaves of Vatican City and San Marino. It is the List of European countries by area, tenth-largest country in Europe by area, covering , and the third-most populous member state of the European Union, with nearly 59 million inhabitants. Italy's capital and List of cities in Italy, largest city is Rome; other major cities include Milan, Naples, Turin, Palermo, Bologna, Florence, Genoa, and Venice. The history of Italy goes back to numerous List of ancient peoples of Italy, Italic peoples—notably including the ancient Romans, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Academy Of Arts & Sciences
The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other Founding Fathers of the United States. It is headquartered in Cambridge, Massachusetts. Membership in the academy is achieved through a nominating petition, review, and election process. The academy's quarterly journal, '' Dædalus'', is published by the MIT Press on behalf of the academy, and has been open-access since January 2021. The academy also conducts multidisciplinary public policy research. Laurie L. Patton has served as President of the Academy since January 2025. History The Academy was established by the Massachusetts legislature on May 4, 1780, charted in order "to cultivate every art and science which may tend to advance the interest, honor, dignity, and happiness of a free, independent, and virtuous people." The sixty-two ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pew Scholar
The Pew Charitable Trusts is an independent non-profit, non-governmental organization (NGO), founded in 1948. Pew's stated mission is to serve the public interest by "improving public policy, informing the public, and invigorating civic life". Pew operates projects and conducts research across five main areas: communities, conservation, finance and economy, governing, and health. In addition, the Pew Research Center is a nonpartisan public polling and think tank that operates as a subsidiary of The Pew Charitable Trusts. History 20th century Pew was established by the merging of several charitable trusts that had been established between 1948 and 1979. The original trusts were created by J. Howard Pew, Mary Ethel Pew, Joseph N. Pew Jr., and Mabel Pew Myrin, the adult sons and daughters of Sun Oil Company founder Joseph N. Pew and his wife, Mary Anderson Pew. Honoring their parents' religious conviction that good works should be done quietly, the original Pew Memorial Foundati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lynne E
Lynne may refer to: *Lynne (surname) *Lynne (given name) *Lynne, Florida Lynne is an Unincorporated area#United States, unincorporated community in Marion County, Florida, Marion County, in the U.S. state of Florida. It is located along Florida State Road 40 in the western edges of Ocala National Forest. History A po ..., an unincorporated community * Lynne, Wisconsin, a town in Oneida County, Wisconsin, United States {{Disambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Howard Y
Howard is a masculine given name derived from the English surname Howard. ''The Oxford Dictionary of English Christian Names'' notes that "the use of this surname as a christian name is quite recent and there seems to be no particular reason for it except that it is the name of several noble families". The surname has a number of possible origins; in the case of the noble family, the likely source is the Norse given name Hávarðr, composed of the elements ''há'' ("high") and ''varðr'' ("guardian"). Diminutives include Howie and Ward. Howard reached peak popularity in the United States in the 1920s, when it ranked as the 26th most popular boys' name. As of 2018, it had fallen to 968th place. People with the given name * Howard Allen (1949–2020), American serial killer * Howard Duane Allman (1946–1971), American guitar virtuoso * Howard Anderson (other), name of several people * Howard Andrew (1934–2021), American poker player * Howard Ashman (1950–1991), A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is a rare neuromuscular disorder that results in the loss of motor neurons and progressive muscle wasting. It is usually diagnosed in infancy or early childhood and if left untreated it is the most common genetic cause of infant death. It may also appear later in life and then have a milder course of the disease. The common feature is the progressive weakness of voluntary muscles, with the arm, leg, and respiratory muscles being affected first. Associated problems may include poor head control, difficulties swallowing, scoliosis, and joint contractures. The age of onset and the severity of symptoms form the basis of the traditional classification of spinal muscular atrophy into a number of types. Spinal muscular atrophy is due to an abnormality (mutation) in the ''SMN1'' gene which encodes SMN, a protein necessary for the survival of motor neurons. Loss of these neurons in the spinal cord prevents signalling between the brain and skeletal mus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spinraza
Nusinersen, marketed as Spinraza, is a medication used in treating spinal muscular atrophy (SMA), a rare neuromuscular disorder. In December 2016, it became the first approved drug used in treating this disorder. Since the condition it treats is so rare, Nusinersen has so-called "orphan drug" designation in the United States and the European Union. Medical uses The drug is used to treat spinal muscular atrophy associated with a mutation in the ''SMN1'' gene. It is administered directly to the central nervous system (CNS) using intrathecal injection. In clinical trials, the drug halted the disease progression. In around 60% of infants affected by type 1 spinal muscular atrophy, it improves motor function. Side effects People treated with nusinersen had an increased risk of upper and lower respiratory infections and congestion, ear infections, constipation, pulmonary aspiration, teething, and scoliosis. There is a risk that growth of infants and children might be stunted. In ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ionis Pharmaceuticals
Ionis Pharmaceuticals, Inc. is a biotechnology company based in Carlsbad, California, that specializes in discovering and developing RNA-targeted therapeutics. The company has three commercially approved medicines: Spinraza ( Nusinersen), Tegsedi ( Inotersen), and Waylivra ( Volanesorsen), and has four drugs in pivotal studies: tominersen for Huntington's disease (together with Roche), tofersen for SOD1- ALS, AKCEA-APO(a)-LRx for cardiovascular disease, and AKCEA-TTR-LRx for all forms of TTR amyloidosis. The company was named Isis Pharmaceuticals until December 2015. History The company was founded in 1989 as Isis Pharmaceuticals by Stanley T. Crooke, a former head of research of GlaxoSmithKline, with the goal of commercializing antisense therapy. In 1992, the company received its first approval by the Food and Drug Administration for an investigational new drug application in 1992 for a genital warts drug candidate. The FDA approval marked the first time for the company t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
State University Of New York, Stony Brook
State most commonly refers to: * State (polity), a centralized political organization that regulates law and society within a territory **Sovereign state, a sovereign polity in international law, commonly referred to as a country **Nation state, a state where the majority identify with a single nation (with shared culture or ethnic group) ** Constituent state, a political subdivision of a state ** Federated state, constituent states part of a federation *** U.S. state * State of nature, a concept within philosophy that describes the way humans acted before forming societies or civilizations State may also refer to: Arts, entertainment, and media Literature * '' State Magazine'', a monthly magazine published by the U.S. Department of State * ''The State'' (newspaper), a daily newspaper in Columbia, South Carolina, United States * '' Our State'', a monthly magazine published in North Carolina and formerly called ''The State'' * The State (Larry Niven), a fictional future gover ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Postdoctoral Research
A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary academic appointment, sometimes in preparation for an academic faculty position. According to data from the US National Science Foundation, the number of holders of PhD in biological sciences who end up in tenure track has consistently dropped from over 50% in 1973 to less than 20% in 2006. They continue their studies or carry out research and further increase expertise in a specialist subject, including integrating a team and acquiring novel skills and research methods. Postdoctoral research is often considered essential while advancing the scholarly mission of the host institution; it is expected to produce relevant publications in peer-reviewed academic journals or conferences. In some countries, postdoctoral research may lead to further for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doctor Of Philosophy
A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of Postgraduate education, graduate study and original research. The name of the degree is most often abbreviated PhD (or, at times, as Ph.D. in North American English, North America), pronounced as three separate letters ( ). The University of Oxford uses the alternative abbreviation "DPhil". PhDs are awarded for programs across the whole breadth of academic fields. Since it is an earned research degree, those studying for a PhD are required to produce original research that expands the boundaries of knowledge, normally in the form of a Thesis, dissertation, and, in some cases, defend their work before a panel of other experts in the field. In many fields, the completion of a PhD is typically required for employment as a university professor, researcher, or scientist. Definition In the context o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
