|
ANDi
ANDi is the first genetically modified rhesus monkey, who was born at Oregon Health Sciences University (OHSU) on October 1, 2001. OHSU named the monkey ANDi because it stands for ''iDNA'' spelled backward. Birth circumstances ANDi was born with an extra glowing gene called green fluorescent protein (GFP). This GFP gene, which is naturally occurring in jellyfish, was taken from a jellyfish and genetically added to ANDi's DNA sequence through his chromosomes. OHSU used rhesus monkeys because they share 95% of the same genes as humans. Genetic modification method During the method in which ANDi was created, 224 eggs were injected with the protein and only 166 or 75% were successfully fertilized. 126 or 76% of these fertilized eggs developed to the four-cell-stage embryos. 40 of the fertilized embryos were implanted in 20 surrogate rhesus mothers, each carrying two embryos. 5 of the surrogates became pregnant. From these five surrogates, three live births proceeded. In these three ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rhesus Monkey
The rhesus macaque (''Macaca mulatta''), colloquially rhesus monkey, is a species of Old World monkey. There are between six and nine recognised subspecies split between two groups, the Chinese-derived and the Indian-derived. Generally brown or grey in colour, it is in length with a tail and weighs . It is native to South Asia, South, Central Asia, Central, and Southeast Asia and has the widest geographic range of all non-human primates, occupying a great diversity of altitudes and habitats. The rhesus macaque is diurnality, diurnal, arboreal, and terrestrial. It is mostly herbivorous, feeding mainly on fruit, but also eating seeds, roots, buds, Bark (botany), bark, and cereals. Rhesus macaques living in cities also eat human food and trash. They are gregarious, with troops comprising 20–200 individuals. The social groups are matrilineal. Individuals communicate with a variety of facial expressions, vocalisations, body postures, and gestures. As a result of the rhesus macaq ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Individual Monkeys
This annotated list of individual monkeys includes monkeys who are in some way famous or notable. The list does not include notable apes or fictional primates. Monkey actors * Crystal – (brown capuchin) played in ''The Hangover Part II'', ''Night at the Museum'', '' Night at the Museum: Battle of the Smithsonian'', '' Night at the Museum: Secret of the Tomb'' and as "Annie's Boobs" in ''Community''. Monkeys used in experiments * Able (rhesus macaque) and Miss Baker ( Peruvian squirrel monkey), both female – the first monkeys sent into space who survived the experience. They were launched on 28 May 1959 in the nose cone of a Jupiter AM-18 missile as a test of NASA's launch facilities at Cape Canaveral and procedures for retrieving astronauts after splashdown. Miss Able died a few days after the mission, but Miss Baker lived another 25 years. * Albert I – (rhesus monkey) the first primate and first mammal launched on a rocket (a June 18, 1948 V-2 flight), although it did ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetra (monkey)
Tetra (born October 12, 1999) is a rhesus macaque that was created through a cloning technique called " embryo splitting". She is the first "cloned" primate by artificial twinning, and was created by a team led by Professor Gerald Schatten of the Oregon National Primate Research Center. Description Tetra was created using embryo splitting, a process where the cells in the embryo are split at the eight–cell stage to create four identical two cell embryos. This was the first time this technique had proven successful in monkeys, although it is often used in cattle. She was the first primate to have been cloned using this "splitting" technique. The first non-human primate derived from nuclear transfer was created in 1997 using a different technique for "cloning". Only two of the four embryos survived to a sufficient stage in which they could be implanted into surrogates, and Tetra was the only one to be delivered successfully after 157 days. The announcement of Tetra was made on 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Individual Monkeys
This annotated list of individual monkeys includes monkeys who are in some way famous or notable. The list does not include List of notable apes, notable apes or List of fictional primates, fictional primates. Monkey actors * Crystal the Monkey, Crystal – (brown capuchin) played in ''The Hangover Part II'', ''Night at the Museum'', ''Night at the Museum: Battle of the Smithsonian'', ''Night at the Museum: Secret of the Tomb'' and as "Annie's Boobs" in ''Community (TV series), Community''. Monkeys used in experiments * Able (rhesus macaque) and Miss Baker (Peruvian squirrel monkey), both female – the first monkeys sent into space who survived the experience. They were launched on 28 May 1959 in the nose cone of a PGM-19 Jupiter, Jupiter AM-18 missile as a test of NASA's launch facilities at John F. Kennedy Space Center, Cape Canaveral and procedures for retrieving astronauts after splashdown. Miss Able died a few days after the mission, but Miss Baker lived another 25 years. * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetically Modified Organism
A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques. The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural Recombination (biology), recombination". A wide variety of organisms have been genetically modified (GM), including animals, plants, and microorganisms. Genetic modification can include the introduction of new genes or enhancing, altering, or Gene knockout, knocking out endogenous genes. In some genetic modifications, genes are transferred Cisgenesis, within the same species, across species (creating transgenic organisms), and even across Kingdom (biology), kingdoms. Creating a genetically modified organism is a multi-step process. Genetic engineers must isolate the gene they wish to insert into the host organism and combine it with o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oregon Health Sciences University
Oregon Health & Science University (OHSU) is a public university, public research university, research university focusing primarily on health sciences with a main campus, including two hospitals, in Portland, Oregon. The institution was founded in 1887 as the University of Oregon Medical Department and later became the University of Oregon Medical School. In 1974, the campus became an independent, self-governed institution called the University of Oregon Health Sciences Center, combining state dentistry, medicine, nursing, and public health programs into a single center. It was renamed Oregon Health Sciences University in 1981 and took its current name in 2001, as part of a merger with the Oregon Graduate Institute (OGI), in Hillsboro, Oregon, Hillsboro. The university has several partnership programs including a joint PharmD Pharmacy program with Oregon State University in Corvallis, Oregon, Corvallis. It is designated as a "Special Focus – Research Institution" according to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Green Fluorescent Protein
The green fluorescent protein (GFP) is a protein that exhibits green fluorescence when exposed to light in the blue to ultraviolet range. The label ''GFP'' traditionally refers to the protein first isolated from the jellyfish ''Aequorea victoria'' and is sometimes called ''avGFP''. However, GFPs have been found in other organisms including corals, sea anemones, zoanithids, copepods and lancelets. The GFP from ''A. victoria'' has a major excitation peak at a wavelength of 395 nm and a minor one at 475 nm. Its emission peak is at 509 nm, which is in the lower green portion of the visible spectrum. The fluorescence quantum yield (QY) of GFP is 0.79. The GFP from the sea pansy ('' Renilla reniformis'') has a single major excitation peak at 498 nm. GFP makes for an excellent tool in many forms of biology due to its ability to form an internal chromophore without requiring any accessory cofactors, gene products, or enzymes / substrates other than molecular ox ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jellyfish
Jellyfish, also known as sea jellies or simply jellies, are the #Life cycle, medusa-phase of certain gelatinous members of the subphylum Medusozoa, which is a major part of the phylum Cnidaria. Jellyfish are mainly free-swimming marine animals, although a few are anchored to the seabed by stalks rather than being motile. They are made of an umbrella-shaped main body made of mesoglea, known as the ''bell'', and a collection of trailing tentacles on the underside. Via pulsating contractions, the bell can provide propulsion for animal locomotion, locomotion through open water. The tentacles are armed with cnidocyte, stinging cells and may be used to capture prey or to defend against predators. Jellyfish have a complex biological life cycle, life cycle, and the medusa is normally the sexual phase, which produces planula larvae. These then disperse widely and enter a sedentary #Life cycle, polyp phase which may include asexual budding before reaching sexual maturity. Jellyfish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromosomes
A chromosome is a package of DNA containing part or all of the genetic material of an organism. In most chromosomes, the very long thin DNA fibers are coated with nucleosome-forming packaging proteins; in eukaryotic cells, the most important of these proteins are the histones. Aided by chaperone proteins, the histones bind to and condense the DNA molecule to maintain its integrity. These eukaryotic chromosomes display a complex three-dimensional structure that has a significant role in transcriptional regulation. Normally, chromosomes are visible under a light microscope only during the metaphase of cell division, where all chromosomes are aligned in the center of the cell in their condensed form. Before this stage occurs, each chromosome is duplicated ( S phase), and the two copies are joined by a centromere—resulting in either an X-shaped structure if the centromere is located equatorially, or a two-armed structure if the centromere is located distally; the joined ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer
Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible Signs and symptoms of cancer, signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in defecation, bowel movements. While these symptoms may indicate cancer, they can also have other causes. List of cancer types, Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor Diet (nutrition), diet, sedentary lifestyle, lack of physical activity or Alcohol abuse, excessive alcohol consumption. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. infectious causes of cancer, Infection with specific viruses, bacteria and parasites is an environmental factor cau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer's
Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the average life expectancy following diagnosis is three to twelve years. The causes of Alzheimer's disease remain poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an allele of apolipoprotein E. Other risk factors include a history of head injury, clinical depression, and high blood pressure. The progression of the dis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diabetes
Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or the cells of the body becoming unresponsive to insulin's effects. Classic symptoms include polydipsia (excessive thirst), polyuria (excessive urination), polyphagia (excessive hunger), weight loss, and blurred vision. If left untreated, the disease can lead to various health complications, including disorders of the cardiovascular system, eye, kidney, and nerves. Diabetes accounts for approximately 4.2 million deaths every year, with an estimated 1.5 million caused by either untreated or poorly treated diabetes. The major types of diabetes are type 1 and type 2. The most common treatment for type 1 is insulin replacement therapy (insulin injections), while anti-diabetic medications (such as metformin and semaglutide) and lifestyle modificatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
