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1,2-Dithiole
In organosulfur chemistry, 1,2-dithioles are a type of heterocycles. The parent of this class of compounds is 1,2-dithiacyclopentene. The anticancer drug oltipraz Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomac ... is a dithiole. Trithiapentalene is an example of theoretical interest. : Many 1,2-dithioles are 1,2-dithiol-3-thiones. See also * Dithiolium salt References {{DEFAULTSORT:Dithiole, 1,2- Dithioles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dithiolium Salt
Dithiolium salts are compounds of the formula RC)3S2sup>+X− (R = H, alkyl, aryl, etc.). These salts consist of a planar organic cation with a variety of anions such as halides. The five-membered ring cations are observed in either of two isomers, 1,2- and 1,3-dithiolium cations. These cations differ with respect to the relative positions of the pair of sulfur atoms. Both isomers feature a planar ring, which is aromatic owing to the presence of 6π electrons. For example, the 1,2-ditholium ring can be represented as an allyl cation of the three carbons, with each sulfur atom donating one of its lone pair In chemistry, a lone pair refers to a pair of valence electrons that are not shared with another atom in a covalent bondIUPAC ''Gold Book'' definition''lone (electron) pair''/ref> and is sometimes called an unshared pair or non-bonding pair. Lone ...s of electrons to give a total of three pairs. Preparation, occurrence 1,2-Dithiolium cations have been prepared from 1,3-dik ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organosulfur Chemistry
Organosulfur chemistry is the study of the properties and synthesis of organosulfur compounds, which are organic compounds that contain sulfur. They are often associated with foul odors, but many of the sweetest compounds known are organosulfur derivatives, e.g., saccharin. Nature is abound with organosulfur compounds—sulfur is vital for life. Of the 20 common amino acids, two (cysteine and methionine) are organosulfur compounds, and the antibiotics penicillin and sulfa drugs both contain sulfur. While sulfur-containing antibiotics save many lives, sulfur mustard is a deadly chemical warfare agent. Fossil fuels, coal, petroleum, and natural gas, which are derived from ancient organisms, necessarily contain organosulfur compounds, the removal of which is a major focus of oil refineries. Sulfur shares the chalcogen group with oxygen, selenium, and tellurium, and it is expected that organosulfur compounds have similarities with carbon–oxygen, carbon–selenium, and carbon–tell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oltipraz
Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radical In chemistry, a superoxide is a compound that contains the superoxide ion, which has the chemical formula . The systematic name of the anion is dioxide(1−). The reactive oxygen ion superoxide is particularly important as the product of th ...s, which can be toxic. References Antiparasitic agents Pyrazines Dithioles Thiocarbonyl compounds Antineoplastic drugs {{antiinfective-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trithiapentalene
Trithiapentalene is an organic chemistry, organic bicyclic molecule containing two sulfur heterocycles. Its 10-π aromatic structure is similar to naphthalene. There has been a literature dispute about whether the connectivity among the three sulfur atoms is a case of rapid tautomerization between two valence tautomers or a Three-center four-electron bond, 3-center 4-electron bond. The reactions have been little studied. It forms a dinickel complex upon reaction with bis(allyl)nickel. See also * Dithiolium salt References {{Reflist Sulfur heterocycles Aromatic compounds Heterocyclic compounds with 2 rings ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oltipraz
Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radical In chemistry, a superoxide is a compound that contains the superoxide ion, which has the chemical formula . The systematic name of the anion is dioxide(1−). The reactive oxygen ion superoxide is particularly important as the product of th ...s, which can be toxic. References Antiparasitic agents Pyrazines Dithioles Thiocarbonyl compounds Antineoplastic drugs {{antiinfective-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
