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(–)-cathinone
Cathinone (; also known as β-ketoamphetamine) is a monoamine alkaloid found in the shrub ''Catha edulis'' (khat) and is chemically similar to ephedrine, cathine, methcathinone and other amphetamines. It is probably the main contributor to the stimulant effect of ''Catha edulis''. Cathinone differs from many other amphetamines in that it has a ketone functional group. Other phenethylamines that share this structure include the stimulants methcathinone, MDPV, mephedrone and the antidepressant bupropion. History Discovery Khat has been cultivated in the Horn of Africa and Arabian Peninsula region of the world for thousands of years. It is most commonly chewed for the euphoric effect it produces. The active ingredient was first proposed in 1930, when cathine was identified as a predominant alkaloid in the plant. Cathine was thought to be the main active ingredient in khat until the 1960s, when it was found that the amount of cathine in the khat leaves is insufficient to produce t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diário Oficial Da União
The ''Diário Oficial da União'' (literally ''Official Diary of the Union''), abbreviated DOU, is the government gazette, official gazette of the Federal Government of Brazil, Federal Government of Brazil. It is published since 1 October 1862 and was created via the Imperial Decree 1,177 of its 9 September as the ''Official Journal of the Empire of Brazil''. Its current name was adopted after Brazil became a federal republic, and the "Union" came into being as the legal personality of the new federal government. The official journal is published by the Imprensa Nacional, Brazilian National Press. Though the journal has been published since 1862, it had many predecessors, as follows: # Gazeta do Rio de Janeiro (10/9/1808 – 29.12.1821) # Gazeta do Rio (1/1/1822 – 31/12/1822) # Diário do Governo (2/1/1823 – 28/6/1833) # Diário Fluminense (21/5/1824 – 24/4/1831) # Correio Oficial (1/7/1833 – 30/6/1836) e (2/1/1830 – 30/12/1840) # Without proper journal (31/12/1840 – ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bupropion
Bupropion, formerly called amfebutamone, and sold under the brand name Wellbutrin among others, is an atypical antidepressant that is indicated in the treatment of major depressive disorder, seasonal affective disorder, and to support smoking cessation. It is also popular as an add-on medication in the cases of "incomplete response" to the first-line selective serotonin reuptake inhibitor (SSRI) antidepressant. Bupropion has several features that distinguish it from other antidepressants: it does not usually cause sexual dysfunction, it is not associated with weight gain and sleepiness, and it is more effective than SSRIs at improving symptoms of hypersomnia and fatigue. Bupropion, particularly the immediate-release formulation, carries a higher risk of seizure than many other antidepressants, hence caution is recommended in patients with a history of seizure disorder. The medication is taken by mouth. Common adverse effects of bupropion with the greatest difference fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caffeine
Caffeine is a central nervous system (CNS) stimulant of the methylxanthine chemical classification, class and is the most commonly consumed Psychoactive drug, psychoactive substance globally. It is mainly used for its eugeroic (wakefulness promoting), ergogenic (physical performance-enhancing), or nootropic (cognitive-enhancing) properties. Caffeine acts by blocking the binding of adenosine at a number of adenosine receptor types, inhibiting the centrally depressant effects of adenosine and enhancing the release of acetylcholine. Caffeine has a three-dimensional structure similar to that of adenosine, which allows it to bind and block its receptors. Caffeine also increases Cyclic adenosine monophosphate, cyclic AMP levels through nonselective Phosphodiesterase inhibitor, inhibition of phosphodiesterase, increases calcium release from intracellular stores, and Receptor antagonist, antagonizes GABA receptor, GABA receptors, although these mechanisms typically occur at concentrati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Djibouti
Djibouti, officially the Republic of Djibouti, is a country in the Horn of Africa, bordered by Somalia to the south, Ethiopia to the southwest, Eritrea in the north, and the Red Sea and the Gulf of Aden to the east. The country has an area of . In antiquity, the territory, together with Ethiopia, Eritrea and Somaliland, was part of the Land of Punt. Nearby Zeila, now in Somaliland, was the seat of the medieval Adal Sultanate, Adal and Ifat Sultanate, Ifat Sultanates. In the late 19th century, the colony of French Somaliland was established after the ruling Dir (clan), Dir, Somali people, Somali, and Afar people, Afar sultans signed treaties with the French, and its Imperial Ethiopian Railway, railroad to Dire Dawa (and later Addis Ababa) allowed it to quickly supersede Zeila as the port for southern Ethiopia and the Ogaden. It was renamed the French Territory of the Afars and the Issas in 1967. A decade later, the Djiboutian people 1977 Afars and Issas independence referendu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ethiopia
Ethiopia, officially the Federal Democratic Republic of Ethiopia, is a landlocked country located in the Horn of Africa region of East Africa. It shares borders with Eritrea to the north, Djibouti to the northeast, Somalia to the east, Kenya to the south, South Sudan to the west, and Sudan to the northwest. Ethiopia covers a land area of . , it has around 128 million inhabitants, making it the List of countries and dependencies by population, thirteenth-most populous country in the world, the List of African countries by population, second-most populous in Africa after Nigeria, and the most populous landlocked country on Earth. The national capital and largest city, Addis Ababa, lies several kilometres west of the East African Rift that splits the country into the African Plate, African and Somali Plate, Somali tectonic plates. Early modern human, Anatomically modern humans emerged from modern-day Ethiopia and set out for the Near East and elsewhere in the Middle Paleolithi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
East Africa
East Africa, also known as Eastern Africa or the East of Africa, is a region at the eastern edge of the Africa, African continent, distinguished by its unique geographical, historical, and cultural landscape. Defined in varying scopes, the region is recognized in the United Nations Statistics Division United Nations geoscheme for Africa, scheme as encompassing 18 sovereign states and 4 territories. It includes the Horn of Africa to the North and Southeastern Africa to the south. Definitions In a narrow sense, particularly in English-speaking contexts, East Africa refers to the area comprising Kenya, Tanzania, and Uganda, largely due to their shared history under the Omani Empire and as parts of the British East Africa Protectorate and German East Africa. Further extending East Africa's definition, the Horn of Africa—comprising Djibouti, Eritrea, Ethiopia, and Somalia—stands out as a distinct geopolitical entity within East Africa.Robert Stock, ''Africa South of the Sahara, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Placebo
A placebo ( ) can be roughly defined as a sham medical treatment. Common placebos include inert tablets (like sugar pills), inert injections (like saline), sham surgery, and other procedures. Placebos are used in randomized clinical trials to test the efficacy of medical treatments. In a placebo-controlled trial, any change in the control group is known as the ''placebo response'', and the difference between this and the result of no treatment is the ''placebo effect''. Placebos in clinical trials should ideally be indistinguishable from so-called verum treatments under investigation, except for the latter's particular hypothesized medicinal effect. This is to shield test participants (with their consent) from knowing who is getting the placebo and who is getting the treatment under test, as patients' and clinicians' expectations of efficacy can influence results. The idea of a placebo effect was discussed in 18th century psychology, but became more prominent in the 20th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Madagascar
Madagascar, officially the Republic of Madagascar, is an island country that includes the island of Madagascar and numerous smaller peripheral islands. Lying off the southeastern coast of Africa, it is the world's List of islands by area, fourth largest island, the List of island countries, second-largest island country, and the List of countries and dependencies by area, 46th largest country overall. Its capital and List of cities in Madagascar, largest city is Antananarivo. Following the prehistoric breakup of the supercontinent Gondwana, Madagascar split from Africa during the Early Jurassic period, around 180 million years ago, and separated from the Indian subcontinent approximately 90 million years ago. This isolation allowed native plants and animals to evolve in relative seclusion; as a result, Madagascar is a biodiversity hotspot and one of the world's 17 megadiverse countries, with over 90% of its wildlife of Madagascar, wildlife being endemic. The island has ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kenya
Kenya, officially the Republic of Kenya, is a country located in East Africa. With an estimated population of more than 52.4 million as of mid-2024, Kenya is the 27th-most-populous country in the world and the 7th most populous in Africa. Kenya's capital and largest city is Nairobi. Its second-largest and oldest city is Mombasa, a major port city located on Mombasa Island. Other major cities within the country include Kisumu, Nakuru & Eldoret. Going clockwise, Kenya is bordered by South Sudan to the northwest (though much of that border includes the disputed Ilemi Triangle), Ethiopia to the north, Somalia to the east, the Indian Ocean to the southeast, Tanzania to the southwest, and Lake Victoria and Uganda to the west. Kenya's geography, climate and population vary widely. In western, rift valley counties, the landscape includes cold, snow-capped mountaintops (such as Batian, Nelion and Point Lenana on Mount Kenya) with vast surrounding forests, wildlife and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yemen
Yemen, officially the Republic of Yemen, is a country in West Asia. Located in South Arabia, southern Arabia, it borders Saudi Arabia to Saudi Arabia–Yemen border, the north, Oman to Oman–Yemen border, the northeast, the south-eastern part of the Arabian Sea to the east, the Gulf of Aden to the south, and the Red Sea to the west, sharing maritime boundary, maritime borders with Djibouti, Eritrea, and Somalia across the Horn of Africa. Covering roughly 455,503 square kilometres (175,871 square miles), with a coastline of approximately , Yemen is the second largest country on the Arabian Peninsula. Sanaa is its constitutional capital and largest city. Yemen's estimated population is 34.7 million, mostly Arabs, Arab Muslims. It is a member of the Arab League, the United Nations, the Non-Aligned Movement and the Organisation of Islamic Cooperation. Owing to its geographic location, Yemen has been at the crossroads of many civilisations for over 7,000 years. In 1200 BCE, the Sab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Euphoria
Euphoria ( ) is the experience (or affect) of pleasure or excitement and intense feelings of well-being and happiness. Certain natural rewards and social activities, such as aerobic exercise, laughter, listening to or making music and dancing, can induce a state of euphoria. Euphoria is also a symptom of certain neurological or neuropsychiatric disorders, such as mania. Romantic love and components of the human sexual response cycle are also associated with the induction of euphoria. Certain drugs, many of which are addictive, can cause euphoria, which at least partially motivates their recreational use. Hedonic hotspots – i.e., the pleasure centers of the brain – are functionally linked. Activation of one hotspot results in the recruitment of the others. Inhibition of one hotspot results in the blunting of the effects of activating another hotspot. Therefore, the simultaneous activation of every hedonic hotspot within the reward system is believed to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
