RefSeq (protein)



Location (UCSC) Chr 14: 100.24 – 100.28 Mb Chr 12: 108.79 – 108.82 Mb PubMed search [3] [4] Wikidata
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YY1 (Yin Yang 1)[5] is a transcriptional repressor protein in humans that is encoded by the YY1 gene.[6][7]


YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "yin-yang." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.[8]


YY1 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100811 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021264 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Thiaville MM, Kim J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes". Critical Reviews in Oncogenesis. 16 (3–4): 199–209. doi:10.1615/critrevoncog.v16.i3-4.40. PMC 3392609Freely accessible. PMID 22248054. 
  6. ^ Shi Y, Seto E, Chang LS, Shenk T (Oct 1991). "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281. 
  7. ^ Zhu W, Lossie AC, Camper SA, Gumucio DL (Apr 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mammalian Genome. 5 (4): 234–6. doi:10.1007/BF00360552. PMID 7912122. 
  8. ^ "Entrez Gene: YY1 YY1 transcription factor". 
  9. ^ Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (Jul 2000). "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Molecular and Cellular Biology. 20 (14): 5096–106. doi:10.1128/mcb.20.14.5096-5106.2000. PMC 85959Freely accessible. PMID 10866666. 
  10. ^ a b c Yao YL, Yang WM, Seto E (Sep 2001). "Regulation of transcription factor YY1 by acetylation and deacetylation". Molecular and Cellular Biology. 21 (17): 5979–91. doi:10.1128/mcb.21.17.5979-5991.2001. PMC 87316Freely accessible. PMID 11486036. 
  11. ^ Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development. 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. PMID 7758944. 
  12. ^ Yang WM, Yao YL, Seto E (Sep 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". The EMBO Journal. 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. PMC 125595Freely accessible. PMID 11532945. 
  13. ^ a b Yang WM, Yao YL, Sun JM, Davie JR, Seto E (Oct 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". The Journal of Biological Chemistry. 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID 9346952. 
  14. ^ Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (Feb 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Research. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511Freely accessible. PMID 9016636. 
  15. ^ Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (Dec 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science. 262 (5141): 1889–92. doi:10.1126/science.8266081. PMID 8266081. 
  16. ^ Yeh TS, Lin YM, Hsieh RH, Tseng MJ (Oct 2003). "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". The Journal of Biological Chemistry. 278 (43): 41963–9. doi:10.1074/jbc.M304353200. PMID 12913000. 
  17. ^ García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". The EMBO Journal. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420Freely accessible. PMID 10369680. 
  18. ^ Huang NE, Lin CH, Lin YS, Yu WC (Jun 2003). "Modulation of YY1 activity by SAP30". Biochemical and Biophysical Research Communications. 306 (1): 267–75. doi:10.1016/s0006-291x(03)00966-5. PMID 12788099. 
  19. ^ Fu CY, Wang P, Tsai HJ (Nov 2017). "Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis". Nucleic Acids Research. 45 (5): 2423–2437. doi:10.1093/nar/gkw1187. 

Further reading

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