Vigo Ordnance Plant
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The Vigo Ordnance Plant, also known as the Vigo Chemical Plant or simply Vigo Plant, was a
United States Army The United States Army (USA) is the land service branch of the United States Armed Forces. It is one of the eight U.S. uniformed services, and is designated as the Army of the United States in the U.S. Constitution.Article II, section 2, cla ...
facility built in 1942 to produce conventional weapons. In 1944 it was converted to produce biological agents for the U.S. bio-weapons program. The plant never produced any bio-weapons before the end of World War II but did produce 8000 pounds of an
anthrax Anthrax is an infection caused by the bacterium ''Bacillus anthracis''. It can occur in four forms: skin, lungs, intestinal, and injection. Symptom onset occurs between one day and more than two months after the infection is contracted. The sk ...
simulant. The plant was transferred to
Pfizer Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer ...
after the war; the company operated it until announcing its closure in 2008.


Location

The Vigo Ordnance Plant was located on of a more than government-owned tract and cost $21 million to build. The facility was constructed in the Honey Creek Township in Vigo County,
Indiana Indiana () is a U.S. state in the Midwestern United States. It is the 38th-largest by area and the 17th-most populous of the 50 States. Its capital and largest city is Indianapolis. Indiana was admitted to the United States as the 19th s ...
. The plant was located about six miles (10 km) south of
Terre Haute Terre Haute ( ) is a city in and the county seat of Vigo County, Indiana, United States, about 5 miles east of the state's western border with Illinois. As of the 2010 census, the city had a population of 60,785 and its metropolitan area had a ...
. The area surrounding the plant was flat, covered with cornfields and dotted by hog farms. The site of the former Vigo Plant is south of
Interstate 70 Interstate 70 (I-70) is a major east–west Interstate Highway System, Interstate Highway in the United States that runs from Interstate 15, I-15 near Cove Fort, Utah, to a park and ride lot just east of Interstate 695 (Maryland), I-695 in ...
near Highway 41 and Indiana State Highways 150 and 63.Pfizer Terre Haute Plant on The Market
", '' Inside Indiana Business'', November 10, 2008, accessed January 11, 2009.


History


Construction and conversion

The U.S. Army Ordnance Corps constructed the Vigo Plant in 1942, prior to the official start of the U.S. biological weapons program. The Vigo Ordnance Plant began producing conventional explosives and munitions on February 18, 1942.McCormick, Mike. ''Terre Haute: Queen City of the Wabash'',
Google Books
, Arcadia Publishing, 2005, pp. 129-130, ().
The Army decommissioned the factory less than year later, and on June 30, 1943 the plant was transferred to the
U.S. Army Corps of Engineers , colors = , anniversaries = 16 June (Organization Day) , battles = , battles_label = Wars , website = , commander1 = ...
. Portions of the Vigo Plant were then leased to the Delco Radio Corporation for the manufacture of military electronics equipment. The plant served in this capacity until May 1944. On May 8, 1944 the Army Special Projects Division (SPD) directed the Vigo Plant to convert its facilities for full-scale
biological agent A biological agent (also called bio-agent, biological threat agent, biological warfare agent, biological weapon, or bioweapon) is a bacterium, virus, protozoan, parasite, fungus, or toxin that can be used purposefully as a weapon in bioterroris ...
production. The plant was converted for
biological warfare Biological warfare, also known as germ warfare, is the use of biological toxins or infectious agents such as bacteria, viruses, insects, and fungi with the intent to kill, harm or incapacitate humans, animals or plants as an act of war. Bio ...
(BW) use by the H.K. Ferguson Construction Company; they added fermenter tanks, slurry heaters, laboratories and the other necessities of a biological warfare facility. The plant was to be the first U.S. anthrax factory and would be utilized filling a British order for
anthrax Anthrax is an infection caused by the bacterium ''Bacillus anthracis''. It can occur in four forms: skin, lungs, intestinal, and injection. Symptom onset occurs between one day and more than two months after the infection is contracted. The sk ...
bombs. In March 1944 the British had placed an order for 500,000 of these bombs which
Winston Churchill Sir Winston Leonard Spencer Churchill (30 November 187424 January 1965) was a British statesman, soldier, and writer who served as Prime Minister of the United Kingdom twice, from 1940 to 1945 Winston Churchill in the Second World War, dur ...
, remarked, should only be considered a "first installment". Meselson, Matthew.
Bioterror: What Can Be Done?
, ''
The New York Review of Books ''The New York Review of Books'' (or ''NYREV'' or ''NYRB'') is a semi-monthly magazine with articles on literature, culture, economics, science and current affairs. Published in New York City, it is inspired by the idea that the discussion of i ...
'', Volume 48, Number 20, December 20, 2001, accessed January 11, 2009.


Bio-weapons production

When it was conceived, the initial plan was for the Vigo Plant to be a production facility for anthrax and
botulinum toxin Botulinum toxin, or botulinum neurotoxin (BoNT), is a neurotoxic protein produced by the bacterium ''Clostridium botulinum'' and related species. It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromusc ...
. The 1944 order converting the plant to a BW facility directed that it become a factory capable of producing 275,000 boutlin bombs or one million anthrax bombs per month. The core of the Vigo Plant's BW operation was the anthrax
fermenter Industrial fermentation is the intentional use of fermentation in manufacturing products useful to humans. In addition to the mass production of fermented foods and drinks, industrial fermentation has widespread applications in chemical industry. ...
s installed during the renovations in 1944. There were 12 20,000 gallon fermenter tanks at Vigo, the total of 240,000 gallons which made it the largest bacterial mass-production line anywhere in the world at the time. After U.S. BW scientists worked through the problems presented by trying to mass-produce bombs that were to be filled with a deadly biological agent, the production line was essentially ready to operate. The line would fill the British four pound anthrax bombsSee also:
M114 bomb The M114 bomb was a four-pound U.S. anti-personnel bomb and biological cluster bomb sub-munition. The M114 was used in the M33 cluster bomb. History The M114 was a sub-munition for the M33 cluster bomb, as such, it was the first standardized U.S ...
.
with an anthrax slurry and then
cluster may refer to: Science and technology Astronomy * Cluster (spacecraft), constellation of four European Space Agency spacecraft * Asteroid cluster, a small asteroid family * Cluster II (spacecraft), a European Space Agency mission to study t ...
them into the M26 cluster adapter, to form the
M33 cluster bomb M33, M-33, or M.33 may refer to: * M-33 (Michigan highway), a state highway in Michigan * M33 cluster bomb, a Cold War-era U.S. biological cluster bomb * HMS ''M33'', an ''M29''-class monitor warship of the Royal Navy * M33 helmet, used by the It ...
.
Regis, Ed Edward Regis, Jr (born 1944) — known as Ed Regis — is an American philosopher, educator and author. He specializes in books and articles about science, philosophy and intelligence. His topics have included nanotechnology, transhumanism and b ...
. ''The Biology of Doom: The History of America's Secret Germ Warfare Project'',
Google Books
, Macmillan, 2000 pages 71-74, ().
Before production could begin, however, safety testing commenced. The scientific director of the U.S. BW program,
Ira Baldwin Ira Lawrence Baldwin (August 20, 1895 – August 9, 1999) was the founder and director emeritus of the Wisconsin Academy Foundation. He began teaching bacteriology at the University of Wisconsin in 1927 and a few years later moved into what becam ...
, selected Walter Nevius, a specialist in pathogen containment, to lead the safety inspections which began when he arrived at Vigo in the summer 1944. Nevius was considered conscientious, so much so that at one point the Army wanted to replace him; this resulted in Baldwin resigning his position and becoming an "advisor" to the U.S. BW program. The testing regimen that followed extended well into 1945. The first tests ran water through the system, to ensure there were no leaks. A second round of tests were run with an anthrax simulant, ''
Bacillus globigii ''Bacillus'' (Latin "stick") is a genus of Gram-positive, rod-shaped bacteria, a member of the phylum ''Bacillota'', with 266 named species. The term is also used to describe the shape (rod) of other so-shaped bacteria; and the plural ''Bacilli ...
''. The plant was pronounced water-tight by Nevius in April 1945 and trial runs with the simulant began in June. By the time the plant was ready to produce the simulant the end of
World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin ...
was on the horizon. The plant was able to produce about 8,000 pounds of ''B. globgii'' before production was halted in October 1945, but was never able to produce any BW agents, including anthrax, before the war ended. As October 1945 ended, approximately $800,000 worth of equipment at Vigo was declared surplus. Eighteen boxcars were loaded with
caustic Caustic most commonly refers to: * Causticity, a property of various corrosive substances ** Sodium hydroxide, sometimes called ''caustic soda'' ** Potassium hydroxide, sometimes called ''caustic potash'' ** Calcium oxide, sometimes called ''caus ...
s,
sulfuric acid Sulfuric acid (American spelling and the preferred IUPAC name) or sulphuric acid ( Commonwealth spelling), known in antiquity as oil of vitriol, is a mineral acid composed of the elements sulfur, oxygen and hydrogen, with the molecular formu ...
, bleach,
tributyl phosphate Tributyl phosphate, known commonly as TBP, is an organophosphorus compound with the chemical formula (CH3CH2CH2CH2O)3PO. This colourless, odorless liquid finds some applications as an extractant and a plasticizer. It is an ester of phosphoric ac ...
and 765,000 explosive detonators and shipped elsewhere for storage. Vigo Ordnance plant was placed on "stand-by" in December 1945, in reality, the demilitarization process had already begun.


Demilitarization

The plant remained on standby to produce "highly classified material" and in February 1947 four areas of the plant were declared restricted. On April 30, 1947 demilitarization of the Vigo Plant began; this allowed prospective buyers to inspect the site. Even with the earlier equipment removal, the fermenters remained behind.
Guillemin, Jeanne Jeanne Harley Guillemin (March 6, 1943 - November 15, 2019) was an American medical anthropologist and author, who for 25 years taught at Boston College as a Professor of Sociology and for over ten years was a senior fellow in the Security Studie ...
. ''Biological Weapons: From the Invention of State-sponsored Programs to Contemporary Bioterrorism'',
Google Books
, Columbia University Press, 2005, pp. 71-73, ().
On December 15, 1947 the
Pfizer Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer ...
company executed a 20-year lease agreement with the government to take over the Vigo site. The company would begin
antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of ...
manufacture at Vigo in 1948 but the military continued to liquidate the surrounding land into 1949. That year a tract was acquired by the
Bureau of Prisons The Federal Bureau of Prisons (BOP) is a United States federal law enforcement agency under the Department of Justice that is responsible for the care, custody, and control of incarcerated individuals who have committed federal crimes; that i ...
to be used as agricultural land, other portions of the Vigo property were acquired by various private entities. The BW production facilities at Vigo were eventually replaced by a more modern factory at
Pine Bluff Arsenal The Pine Bluff Arsenal is a United States Army installation in Jefferson County, Arkansas, about eight miles northwest of Pine Bluff and thirty miles southeast of Little Rock. Pine Bluff Arsenal is one of nine Army installations in the United ...
in 1954.


Pfizer's ownership

After the lease agreement, and later the sale of the plant, was finalized the company transferred John E. McKeen to the Vigo site in 1948 in preparation for the production of
streptomycin Streptomycin is an antibiotic medication used to treat a number of bacterial infections, including tuberculosis, ''Mycobacterium avium'' complex, endocarditis, brucellosis, ''Burkholderia'' infection, plague, tularemia, and rat bite fever. Fo ...
. The main objective of Pfizer's Vigo operation in the years after the war was the production of veterinary antibiotics. The large fermenters were used during the period after the war to produce
penicillin Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from ''Penicillium'' moulds, principally '' P. chrysogenum'' and '' P. rubens''. Most penicillins in clinical use are synthesised by P. chrysogenum using ...
but afterwards sat dormant for decades. Of the areas at Vigo not utilized by Pfizer, most were left undisturbed. Adjacent to the old BW buildings the company constructed their own facilities for drug manufacturing. Mangold, Tom. ''Plague Wars: A True Story of Biological Warfare'',
Google Books
, Macmillan, 1999, pp. 200-208, ().
After operating the Vigo plant since 1948 Pfizer announced in October 2007 that 600 of the plant's 750 employees would be placed on paid leave.Greninger, Howard.

, ''
Tribune-Star The ''Tribune-Star'' is a seven-day morning daily newspaper based in Terre Haute, Indiana, covering the Wabash Valley area of Indiana and Illinois. It is owned by Community Newspaper Holdings. Counties within the newspaper's coverage areas includ ...
'', November 13, 2007, accessed January 11, 2009.
The announcement followed disappointing sales for the plant's flagship product, an inhaled insulin known as Exubera. Beginning in 1999, Pfizer had invested $300 million in the plant and hired 400 additional employees, Pfizer's Vigo location was declared the sole producer of Exubera.
Editorial board The editorial board is a group of experts, usually at a publication, who dictate the tone and direction the publication's editorial policy will take. Mass media At a newspaper, the editorial board usually consists of the editorial page editor, a ...
.
Pfizer’s track record provides ray of hope on sad day
, (
Editorial An editorial, or leading article (UK) or leader (UK) is an article written by the senior editorial people or publisher of a newspaper, magazine, or any other written document, often unsigned. Australian and major United States newspapers, suc ...
), ''
Tribune-Star The ''Tribune-Star'' is a seven-day morning daily newspaper based in Terre Haute, Indiana, covering the Wabash Valley area of Indiana and Illinois. It is owned by Community Newspaper Holdings. Counties within the newspaper's coverage areas includ ...
'', October 18, 2007, accessed January 11, 2009.
In January 2008 those employees on paid leave were permanently eliminated. The company announced in May 2008 the remaining 140 jobs, occupied making antibiotics Cefobid and
Unasyn Unasyn is the trade name for two related antibiotic drugs: * Ampicillin/sulbactam, a fixed-dose combination medication of the penicillin antibiotic combination ampicillin/sulbactam * Sultamicillin Sultamicillin, sold under the brand name Unasyn am ...
, at the plant would be eliminated and the plant closed. In November 2008 the company announced the site and its buildings were for sale.Staff.
Pfizer puts closed Terre Haute plant up for sale
,
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via ''
Chicago Tribune The ''Chicago Tribune'' is a daily newspaper based in Chicago, Illinois, United States, owned by Tribune Publishing. Founded in 1847, and formerly self-styled as the "World's Greatest Newspaper" (a slogan for which WGN radio and television ar ...
'', November 10, 2008, accessed January 11, 2009.


Russian tour

Per a 1994 arms-control agreement between the United States and Russia each nation was permitted to inspect three sites in the other country that it suspected were biological warfare facilities.Carroll, Michael. ''Lab 257: The Disturbing Story of the Government's Secret Plum Island Germ Laboratory'',
Google Books
, HarperCollins, 2004, pp. 233-34, ().
The Russians chose to tour Pfizer's main research center in
Groton, Connecticut Groton is a town in New London County, Connecticut located on the Thames River. It is the home of General Dynamics Electric Boat, which is the major contractor for submarine work for the United States Navy. The Naval Submarine Base New London is ...
, the Plum Island facilities, including Building 101, and the Vigo Ordnance Plant. The Russians were shown the decrepit military facilities at Vigo, many of which were shuttered, padlocked and in an obvious state of disrepair. When the Russians observed the fermenters, they asserted that it was evidence of a secret, illegal U.S. BW program. Russian reaction to the tours, in general, was not good, and a negative report of their visit followed when they returned to Russia. The report maintained that the facilities could potentially be used for BW.


See also

*
Fort Detrick Fort Detrick () is a United States Army Futures Command installation located in Frederick, Maryland. Historically, Fort Detrick was the center of the U.S. biological weapons program from 1943 to 1969. Since the discontinuation of that program, i ...
*
Fort Terry Fort Terry was a coastal fortification on Plum Island, a small island just off Orient Point, New York, United States. This strategic position afforded it a commanding view over the Atlantic entrance to the commercially vital Long Island Sound. ...
*
Granite Peak Installation The Granite Peak Installation (GPI) — also known as Granite Peak Range — was a U.S. biological weapons testing facility located on of Dugway Proving Ground in Utah. The GPI was a sub-installation of Dugway but had its own facilities, includi ...
* Horn Island Testing Station *
Plum Island Animal Disease Center Plum Island Animal Disease Center (PIADC) is a United States federal research facility dedicated to the study of foreign animal diseases of livestock. It is part of the Department of Homeland Security Directorate for Science and Technology, an ...


Notes


External links


Records of Chemical Plants
'' National Archives'', Records of the Chemical Warfare Service, Guide to Federal Records, accessed January 11, 2009. {{coord, 39, 21, 32, N, 87, 24, 40, W, region:US-IN_type:landmark, display=title Buildings and structures in Vigo County, Indiana Biological warfare facilities Pfizer Closed installations of the United States Army Indiana in World War II United States biological weapons program