Trihalomethanes (THMs) are chemical compounds in which three of the four hydrogen atoms of methane (CH4) are replaced by halogen atoms. Many trihalomethanes find uses in industry as solvents or refrigerants. THMs are also environmental pollutants, and many are considered carcinogenic. Trihalomethanes with all the same halogen atoms are called haloforms. Several of these are easy to prepare through the haloform reaction.[citation needed]

Trihalomethanes were the subject of the first drinking water regulations issued after passage of the U.S. Safe Drinking Water Act in 1974.[1]

Table of common trihalomethanes

Trihalomethanes are formed as a by-product predominantly when chlorine is used to disinfect drinking water. They are generally referred to as disinfection by-products. They result fro

Only chloroform has significant applications of the haloforms. In the predominant application, chloroform is required for the production of tetrafluoroethylene, precursor to teflon.[2] Chloroform is fluorinated by reaction with hydrogen fluoride to produce chlorodifluoromethane (R-22). Pyrolysis of chlorodifluoromethane (at 550-750 °C) yields TFE, with difluorocarbene as an intermediate.

CHCl3 + 2 HF → CHClF2 + 2 HCl
2 CHClF2 → C2F4 + 2 HCl


Chloroform is a common solvent in organic chemistry.

solvent in organic chemistry.

Water pollutants

  1. ^ EPA Alumni Association: Senior EPA officials discuss early implementation of the Safe Drinking Water Act of 1974, Video, Transcript (see pages 12-13).
  2. ^ chloroform is also formed in swimming pools that are disinfected with chlorine or hypochlorite in the haloform reaction with organic substances (e.g. urine, sweat, hair and skin particles). Although it is possible to inhale THMs, the U.S. EPA has determined that this exposure is minimal compared to that from consumption. In swimmers, uptake of THMs is greatest via the skin with dermal absorption accounting for 80% of THM uptake.[3] Exercising in a chlorinated pool increases the toxicity of a "safe" chlorinated pool atmosphere[4] with toxic effects of chlorine byproducts greater in young swimmers than older swimmers.[5] Studies in adolescents have shown an inverse relationship between serum testosterone levels and the amount of time spent in public pools. Chlorination by-products have been linked as a probable cause.[6]

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