Transcriptional enhancer factor TEF-3 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''TEAD4''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.
Members of the family in mammals are
TEAD1
Transcriptional enhancer factor TEF-1 also known as TEA domain family member 1 (TEAD1) and transcription factor 13 (TCF-13) is a protein that in humans is encoded by the ''TEAD1'' gene. TEAD1 was the first member of the TEAD family of transcriptio ...
,
TEAD2
TEAD2 (ETF, ETEF-1, TEF-4), together with TEAD1, defines a novel family of transcription factors, the TEAD family, highly conserved through evolution.
TEAD proteins were notably found in ''Drosophila'' (Scalloped), ''C. elegans'' (egl -44), ''S ...
,
TEAD3
Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the ''TEAD3'' gene.
Function
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS ...
, TEAD4. TEAD4 is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.
Gene ablation experiments in mice (i.e. knockout mice) showed that TEAD4 is essential for the formation of blastocysts during preimplantation embryo development.
Although it was originally hypothesized to be essential for specification of trophectoderm lineage, it was later shown that functional trophectoderm can be produced leading to formation of blastocysts under in vitro conditions that suppress oxidative stress.
Transcriptional coregulators, such as
WWTR1 (TAZ) bind to members in this transcription factor family.
References
Further reading
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External links
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Transcription factors
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