__NOTOC__ A sialogogue (also spelled sialagogue, ptysmagogue or ptyalagogue) is a

drug A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via insuffla ...

or substance that increases the flow rate of

saliva Saliva (commonly referred to as spit) is an extracellular fluid produced and secreted by salivary glands in the mouth. In humans, saliva is around 99% water, plus electrolytes, mucus, white blood cells, epithelial cells (from which DNA can be ...

. Sialogogues can be used in the treatment of

xerostomia Xerostomia, also known as dry mouth, is dryness in the mouth, which may be associated with a change in the composition of saliva, or reduced salivary flow, or have no identifiable cause. This symptom is very common and is often seen as a side ef ...

(the subjective feeling of having a dry mouth), to stimulate any functioning

salivary gland The salivary glands in mammals are exocrine glands that produce saliva through a system of ducts. Humans have three paired major salivary glands (parotid, submandibular, and sublingual), as well as hundreds of minor salivary glands. Salivary gla ...

tissue to produce more saliva. Saliva has a bactericidal effect, so when low levels of it are secreted, the risk of

caries Tooth decay, also known as cavities or caries, is the breakdown of teeth due to acids produced by bacteria. The cavities may be a number of different colors from yellow to black. Symptoms may include pain and difficulty with eating. Complicatio ...

increases. Not only this, but fungal infections such as oral candidosis also can be a consequence of low salivary flow rates. The

buffer Buffer may refer to: Science * Buffer gas, an inert or nonflammable gas * Buffer solution, a solution used to prevent changes in pH * Buffering agent, the weak acid or base in a buffer solution * Lysis buffer, in cell biology * Metal ion buffer * ...

effect of saliva is also important, neutralising acids that cause tooth enamel demineralisation. The following are used in dentistry to treat xerostomia: *Parasympathomimetic drugs act on parasympathetic

muscarinic receptors Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells. They play several roles, including acting as the main end-rece ...

to induce an increased saliva flow. The M3 receptor has been identified as the principal target to increase salivary flow rates.Melvin JE, Yule D, Shuttleworth T, Begenisich T. REGULATION OF FLUID AND ELECTROLYTE SECRETION IN SALIVARY GLAND ACINAR CELLS. Annual Review of Physiology. 2005 Mar 17;67(1):445–69.

Pilocarpine Pilocarpine is a medication used to reduce pressure inside the eye and treat dry mouth. As eye drops it is used to manage angle closure glaucoma until surgery can be performed, ocular hypertension, primary open angle glaucoma, and to bring abo ...

is an example; the maximum dose of this drug is 30 mg/day. Contraindications include many lung conditions, such as asthma, cardiac problems, epilepsy and Parkinson's disease; side effects include flushing, increased urination, increase perspiration, and GI disturbances. *Chewing gum induces stimulated saliva secretion of the minor salivary glands in the oral cavity. During mastication (chewing), the resultant compression forces acting on the

periodontal ligament The periodontal ligament, commonly abbreviated as the PDL, is a group of specialized connective tissue fibers that essentially attach a tooth to the alveolar bone within which it sits. It inserts into root cementum one side and onto alveolar b ...

cause the stimulated release of gingival crevicular fluid. Further salivation can be also achieved by the stimulation of taste receptors (parasympathetic fibers from the

chorda tympani The chorda tympani is a branch of the facial nerve that originates from the taste buds in the front of the tongue, runs through the middle ear, and carries taste messages to the brain. It joins the facial nerve (cranial nerve VII) inside the fa ...

and the

lingual nerve The lingual nerve carries sensory innervation from the anterior two-thirds of the tongue. It contains fibres from both the mandibular division of the trigeminal nerve (CN V3 ) and from the facial nerve (CN VII). The fibres from the trigeminal nerv ...

are involved). *Malic and ascorbic acid are effective sialogogues, but are not ideal as they cause demineralisation of

tooth enamel Tooth enamel is one of the four major Tissue (biology), tissues that make up the tooth in humans and many other animals, including some species of fish. It makes up the normally visible part of the tooth, covering the Crown (tooth), crown. The ...

Historical source from plants

A tincture is prepared from the root of the pyrethrium (

pyrethrum ''Pyrethrum'' was a genus of several Old World plants now classified as ''Chrysanthemum'' or ''Tanacetum'' which are cultivated as ornamentals for their showy flower heads. Pyrethrum continues to be used as a common name for plants formerly inclu ...

) or pellitory (a number of plants in the ''

Chrysanthemum Chrysanthemums (), sometimes called mums or chrysanths, are flowering plants of the genus ''Chrysanthemum'' in the family Asteraceae. They are native to East Asia and northeastern Europe. Most species originate from East Asia and the center ...

'' family). It is found growing in Levant and parts of Limerick and Clare in

Ireland Ireland ( ; ga, Éire ; Ulster Scots dialect, Ulster-Scots: ) is an island in the Atlantic Ocean, North Atlantic Ocean, in Northwestern Europe, north-western Europe. It is separated from Great Britain to its east by the North Channel (Grea ...

. The root powder was used as flavouring in tooth powders in the past.Jude, "Medicinal and Perfumery Plants and Herbs of Ireland", MH Gill and son, (1933) pp.36

Herbs with sialogogue action

Bloodroot ''Sanguinaria canadensis'', bloodroot, is a Perennial plant, perennial, herbaceous flowering plant native to eastern North America. It is the monotypic genus, only species in the genus ''Sanguinaria'', included in the poppy family Papaveraceae, ...

(''

Sanguinaria ''Sanguinaria canadensis'', bloodroot, is a perennial, herbaceous flowering plant native to eastern North America. It is the only species in the genus ''Sanguinaria'', included in the poppy family Papaveraceae, and is most closely related to ...

canadensis'') * Blue flag (''

Iris Iris most often refers to: *Iris (anatomy), part of the eye *Iris (mythology), a Greek goddess * ''Iris'' (plant), a genus of flowering plants * Iris (color), an ambiguous color term Iris or IRIS may also refer to: Arts and media Fictional ent ...

versicolor'') *

Cayenne pepper The cayenne pepper is a type of ''Capsicum annuum''. It is usually a moderately hot chili pepper used to flavor dishes. Cayenne peppers are a group of tapering, 10 to 25 cm long, generally skinny, mostly red-colored peppers, often with ...

(''

Capsicum ''Capsicum'' () is a genus of flowering plants in the Solanum, nightshade family Solanaceae, native to Americas, the Americas, cultivated worldwide for their chili pepper or bell pepper fruit. Etymology and names The generic name may come f ...

annuum'') * Centaury (''

Centaurium ''Centaurium'' (centaury) is a genus of 20 species in the gentian family (Gentianaceae), tribe Chironieae, subtribe Chironiinae. The genus was named after the centaur Chiron, famed in Greek mythology for his skill in medicinal herbs. It is dist ...

erythraea'') *Chilcoatl / Azteca gold root ('' Heliopsis longipes'') * Great yellow gentian (''

Gentiana ''Gentiana'' is a genus of flowering plants belonging to the gentian family (Gentianaceae), the tribe Gentianeae, and the monophyletic subtribe Gentianinae. With about 400 species it is considered a large genus. They are notable for their mostl ...

lutea'') * Jambu ('' Acmella oleracea'') *

Ginger Ginger (''Zingiber officinale'') is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice A spice is a seed, fruit, root, bark, or other plant substance primarily used for flavoring or coloring food. Spices ...

(''

Zingiber The genus ''Zingiber'' is native to Southeast Asia especially in Thailand, China, the Indian Subcontinent, and New Guinea. It contains the true gingers, plants grown the world over for their culinary value. The most well known are '' Z. officina ...

officinale'') * Northern prickly-ash (''

Zanthoxylum ''Zanthoxylum'' is a genus of about 250 species of deciduous and evergreen trees, shrubs and climbers in the family Rutaceae that are native to warm temperate and subtropical areas worldwide. It is the type genus of the tribe Zanthoxyleae in ...

americanum'') * Senega (''

Polygala ''Polygala'' is a large genus of flowering plants belonging to the family Polygalaceae. They are commonly known as milkworts or snakeroots. The genus is distributed widely throughout much of the world Hypersalivation Hypersalivation, or ptyalism, also known as sialorrhea or hypersialosis is the excessive production of saliva. It has also been defined as increased amount of saliva in the mouth, which may also be caused by decreased clearance of saliva.Medscape ...

References

{{reflist Drugs Dentistry Otorhinolaryngology